Protein annotation in the era of personal genomics

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Protein annotation in the era of personal genomics. / Blicher, Thomas; Gupta, Ramneek; Wesolowska, Agata; Jensen, Lars Juhl; Brunak, Søren.

In: Current Opinion in Structural Biology, Vol. 20, No. 3, 01.06.2010, p. 335-41.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Blicher, T, Gupta, R, Wesolowska, A, Jensen, LJ & Brunak, S 2010, 'Protein annotation in the era of personal genomics', Current Opinion in Structural Biology, vol. 20, no. 3, pp. 335-41. https://doi.org/10.1016/j.sbi.2010.03.008

APA

Blicher, T., Gupta, R., Wesolowska, A., Jensen, L. J., & Brunak, S. (2010). Protein annotation in the era of personal genomics. Current Opinion in Structural Biology, 20(3), 335-41. https://doi.org/10.1016/j.sbi.2010.03.008

Vancouver

Blicher T, Gupta R, Wesolowska A, Jensen LJ, Brunak S. Protein annotation in the era of personal genomics. Current Opinion in Structural Biology. 2010 Jun 1;20(3):335-41. https://doi.org/10.1016/j.sbi.2010.03.008

Author

Blicher, Thomas ; Gupta, Ramneek ; Wesolowska, Agata ; Jensen, Lars Juhl ; Brunak, Søren. / Protein annotation in the era of personal genomics. In: Current Opinion in Structural Biology. 2010 ; Vol. 20, No. 3. pp. 335-41.

Bibtex

@article{f962bba756754941bcafce524e79bfea,
title = "Protein annotation in the era of personal genomics",
abstract = "Protein annotation provides a condensed and systematic view on the function of individual proteins. It has traditionally dealt with sorting proteins into functional categories, which for example has proven to be successful for the comparison of different species. However, if we are to understand the differences between many individuals of the same species-humans in particular - the focus needs be on the functional impact of individual residue variation. To fulfil the promises of personal genomics, we need to start asking not only what is in a genome but also how millions of small differences between individual genomes affect protein function and in turn human health.",
keywords = "Amino Acid Motifs, Amino Acid Sequence, Animals, Genome, Human, Genomics, Humans, Molecular Sequence Data, Proteins",
author = "Thomas Blicher and Ramneek Gupta and Agata Wesolowska and Jensen, {Lars Juhl} and S{\o}ren Brunak",
note = "Copyright 2010 Elsevier Ltd. All rights reserved.",
year = "2010",
month = jun,
day = "1",
doi = "10.1016/j.sbi.2010.03.008",
language = "English",
volume = "20",
pages = "335--41",
journal = "Current Opinion in Structural Biology",
issn = "0959-440X",
publisher = "Elsevier Ltd. * Current Opinion Journals",
number = "3",

}

RIS

TY - JOUR

T1 - Protein annotation in the era of personal genomics

AU - Blicher, Thomas

AU - Gupta, Ramneek

AU - Wesolowska, Agata

AU - Jensen, Lars Juhl

AU - Brunak, Søren

N1 - Copyright 2010 Elsevier Ltd. All rights reserved.

PY - 2010/6/1

Y1 - 2010/6/1

N2 - Protein annotation provides a condensed and systematic view on the function of individual proteins. It has traditionally dealt with sorting proteins into functional categories, which for example has proven to be successful for the comparison of different species. However, if we are to understand the differences between many individuals of the same species-humans in particular - the focus needs be on the functional impact of individual residue variation. To fulfil the promises of personal genomics, we need to start asking not only what is in a genome but also how millions of small differences between individual genomes affect protein function and in turn human health.

AB - Protein annotation provides a condensed and systematic view on the function of individual proteins. It has traditionally dealt with sorting proteins into functional categories, which for example has proven to be successful for the comparison of different species. However, if we are to understand the differences between many individuals of the same species-humans in particular - the focus needs be on the functional impact of individual residue variation. To fulfil the promises of personal genomics, we need to start asking not only what is in a genome but also how millions of small differences between individual genomes affect protein function and in turn human health.

KW - Amino Acid Motifs

KW - Amino Acid Sequence

KW - Animals

KW - Genome, Human

KW - Genomics

KW - Humans

KW - Molecular Sequence Data

KW - Proteins

U2 - 10.1016/j.sbi.2010.03.008

DO - 10.1016/j.sbi.2010.03.008

M3 - Journal article

C2 - 20403684

VL - 20

SP - 335

EP - 341

JO - Current Opinion in Structural Biology

JF - Current Opinion in Structural Biology

SN - 0959-440X

IS - 3

ER -

ID: 33748716