Profiles of glucose metabolism in different prediabetes phenotypes, classified by fasting glycemia, 2-hour OGTT, glycated hemoglobin, and 1-hour OGTT: An IMI DIRECT study

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Standard

Profiles of glucose metabolism in different prediabetes phenotypes, classified by fasting glycemia, 2-hour OGTT, glycated hemoglobin, and 1-hour OGTT : An IMI DIRECT study. / Tura, Andrea; Grespan, Eleonora; Göbl, Christian S; Koivula, Robert W; Franks, Paul W; Pearson, Ewan R; Walker, Mark; Forgie, Ian M; Giordano, Giuseppe N; Pavo, Imre; Ruetten, Hartmut; Dermitzakis, Emmanouil T; McCarthy, Mark I; Pedersen, Oluf; Schwenk, Jochen M; Adamski, Jerzy; De Masi, Federico; Tsirigos, Konstantinos D; Brunak, Søren; Viñuela, Ana; Mahajan, Anubha; McDonald, Timothy J; Kokkola, Tarja; Vangipurapu, Jagadish; Cederberg, Henna; Laakso, Markku; Rutters, Femke; Elders, Petra J M; Koopman, Anitra D M; Beulens, Joline W; Ridderstråle, Martin; Hansen, Tue H; Allin, Kristine H; Hansen, Torben; Vestergaard, Henrik; Mari, Andrea; IMI-DIRECT consortium.

In: Diabetes, Vol. 70, No. 6, db210227, 2021.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Tura, A, Grespan, E, Göbl, CS, Koivula, RW, Franks, PW, Pearson, ER, Walker, M, Forgie, IM, Giordano, GN, Pavo, I, Ruetten, H, Dermitzakis, ET, McCarthy, MI, Pedersen, O, Schwenk, JM, Adamski, J, De Masi, F, Tsirigos, KD, Brunak, S, Viñuela, A, Mahajan, A, McDonald, TJ, Kokkola, T, Vangipurapu, J, Cederberg, H, Laakso, M, Rutters, F, Elders, PJM, Koopman, ADM, Beulens, JW, Ridderstråle, M, Hansen, TH, Allin, KH, Hansen, T, Vestergaard, H, Mari, A & IMI-DIRECT consortium 2021, 'Profiles of glucose metabolism in different prediabetes phenotypes, classified by fasting glycemia, 2-hour OGTT, glycated hemoglobin, and 1-hour OGTT: An IMI DIRECT study', Diabetes, vol. 70, no. 6, db210227. https://doi.org/10.2337/db21-0227

APA

Tura, A., Grespan, E., Göbl, C. S., Koivula, R. W., Franks, P. W., Pearson, E. R., Walker, M., Forgie, I. M., Giordano, G. N., Pavo, I., Ruetten, H., Dermitzakis, E. T., McCarthy, M. I., Pedersen, O., Schwenk, J. M., Adamski, J., De Masi, F., Tsirigos, K. D., Brunak, S., ... IMI-DIRECT consortium (2021). Profiles of glucose metabolism in different prediabetes phenotypes, classified by fasting glycemia, 2-hour OGTT, glycated hemoglobin, and 1-hour OGTT: An IMI DIRECT study. Diabetes, 70(6), [db210227]. https://doi.org/10.2337/db21-0227

Vancouver

Tura A, Grespan E, Göbl CS, Koivula RW, Franks PW, Pearson ER et al. Profiles of glucose metabolism in different prediabetes phenotypes, classified by fasting glycemia, 2-hour OGTT, glycated hemoglobin, and 1-hour OGTT: An IMI DIRECT study. Diabetes. 2021;70(6). db210227. https://doi.org/10.2337/db21-0227

Author

Tura, Andrea ; Grespan, Eleonora ; Göbl, Christian S ; Koivula, Robert W ; Franks, Paul W ; Pearson, Ewan R ; Walker, Mark ; Forgie, Ian M ; Giordano, Giuseppe N ; Pavo, Imre ; Ruetten, Hartmut ; Dermitzakis, Emmanouil T ; McCarthy, Mark I ; Pedersen, Oluf ; Schwenk, Jochen M ; Adamski, Jerzy ; De Masi, Federico ; Tsirigos, Konstantinos D ; Brunak, Søren ; Viñuela, Ana ; Mahajan, Anubha ; McDonald, Timothy J ; Kokkola, Tarja ; Vangipurapu, Jagadish ; Cederberg, Henna ; Laakso, Markku ; Rutters, Femke ; Elders, Petra J M ; Koopman, Anitra D M ; Beulens, Joline W ; Ridderstråle, Martin ; Hansen, Tue H ; Allin, Kristine H ; Hansen, Torben ; Vestergaard, Henrik ; Mari, Andrea ; IMI-DIRECT consortium. / Profiles of glucose metabolism in different prediabetes phenotypes, classified by fasting glycemia, 2-hour OGTT, glycated hemoglobin, and 1-hour OGTT : An IMI DIRECT study. In: Diabetes. 2021 ; Vol. 70, No. 6.

Bibtex

@article{113805187589423ab133a0c27440ce6e,
title = "Profiles of glucose metabolism in different prediabetes phenotypes, classified by fasting glycemia, 2-hour OGTT, glycated hemoglobin, and 1-hour OGTT: An IMI DIRECT study",
abstract = "Differences in glucose metabolism among categories of prediabetes have not been systematically investigated. In this longitudinal study, participants (N=2111) underwent 2h-75g OGTT at baseline and 48 months. HbA1c was also measured. We classified participants as having isolated prediabetes defect (impaired fasting glucose, IFG; impaired glucose tolerance, IGT; HbA1c-prediabetes, IA1c), two defects (IFG+IGT, IFG+IA1c, IGT+IA1c), or all defects (IFG+IGT+IA1c). Beta-cell function (BCF) and insulin sensitivity (IS) were assessed from OGTT. At baseline, when pooling participants with isolated defects, they showed impairment in both BCF and IS compared to healthy controls. Pooled groups with two or three defects showed progressive further deterioration. Among groups with isolated defect, IGT showed lower IS, insulin secretion at reference glucose (ISRr), and insulin secretion potentiation (p<0.002). Conversely, IA1c showed higher IS and ISRr (p<0.0001). Among groups with two defects, we similarly found differences in both BCF and IS. At 48 months, we found higher type 2 diabetes incidence for progressively increasing number of prediabetes defects (odds ratio >2, p<0.008). In conclusion, the prediabetes groups showed differences in type/degree of glucometabolic impairment. Compared to the pooled group with isolated defects, those with double or triple defect showed progressive differences in diabetes incidence.",
author = "Andrea Tura and Eleonora Grespan and G{\"o}bl, {Christian S} and Koivula, {Robert W} and Franks, {Paul W} and Pearson, {Ewan R} and Mark Walker and Forgie, {Ian M} and Giordano, {Giuseppe N} and Imre Pavo and Hartmut Ruetten and Dermitzakis, {Emmanouil T} and McCarthy, {Mark I} and Oluf Pedersen and Schwenk, {Jochen M} and Jerzy Adamski and {De Masi}, Federico and Tsirigos, {Konstantinos D} and S{\o}ren Brunak and Ana Vi{\~n}uela and Anubha Mahajan and McDonald, {Timothy J} and Tarja Kokkola and Jagadish Vangipurapu and Henna Cederberg and Markku Laakso and Femke Rutters and Elders, {Petra J M} and Koopman, {Anitra D M} and Beulens, {Joline W} and Martin Ridderstr{\aa}le and Hansen, {Tue H} and Allin, {Kristine H} and Torben Hansen and Henrik Vestergaard and Andrea Mari and {IMI-DIRECT consortium}",
note = "{\textcopyright} 2021 by the American Diabetes Association.",
year = "2021",
doi = "10.2337/db21-0227",
language = "English",
volume = "70",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association",
number = "6",

}

RIS

TY - JOUR

T1 - Profiles of glucose metabolism in different prediabetes phenotypes, classified by fasting glycemia, 2-hour OGTT, glycated hemoglobin, and 1-hour OGTT

T2 - An IMI DIRECT study

AU - Tura, Andrea

AU - Grespan, Eleonora

AU - Göbl, Christian S

AU - Koivula, Robert W

AU - Franks, Paul W

AU - Pearson, Ewan R

AU - Walker, Mark

AU - Forgie, Ian M

AU - Giordano, Giuseppe N

AU - Pavo, Imre

AU - Ruetten, Hartmut

AU - Dermitzakis, Emmanouil T

AU - McCarthy, Mark I

AU - Pedersen, Oluf

AU - Schwenk, Jochen M

AU - Adamski, Jerzy

AU - De Masi, Federico

AU - Tsirigos, Konstantinos D

AU - Brunak, Søren

AU - Viñuela, Ana

AU - Mahajan, Anubha

AU - McDonald, Timothy J

AU - Kokkola, Tarja

AU - Vangipurapu, Jagadish

AU - Cederberg, Henna

AU - Laakso, Markku

AU - Rutters, Femke

AU - Elders, Petra J M

AU - Koopman, Anitra D M

AU - Beulens, Joline W

AU - Ridderstråle, Martin

AU - Hansen, Tue H

AU - Allin, Kristine H

AU - Hansen, Torben

AU - Vestergaard, Henrik

AU - Mari, Andrea

AU - IMI-DIRECT consortium

N1 - © 2021 by the American Diabetes Association.

PY - 2021

Y1 - 2021

N2 - Differences in glucose metabolism among categories of prediabetes have not been systematically investigated. In this longitudinal study, participants (N=2111) underwent 2h-75g OGTT at baseline and 48 months. HbA1c was also measured. We classified participants as having isolated prediabetes defect (impaired fasting glucose, IFG; impaired glucose tolerance, IGT; HbA1c-prediabetes, IA1c), two defects (IFG+IGT, IFG+IA1c, IGT+IA1c), or all defects (IFG+IGT+IA1c). Beta-cell function (BCF) and insulin sensitivity (IS) were assessed from OGTT. At baseline, when pooling participants with isolated defects, they showed impairment in both BCF and IS compared to healthy controls. Pooled groups with two or three defects showed progressive further deterioration. Among groups with isolated defect, IGT showed lower IS, insulin secretion at reference glucose (ISRr), and insulin secretion potentiation (p<0.002). Conversely, IA1c showed higher IS and ISRr (p<0.0001). Among groups with two defects, we similarly found differences in both BCF and IS. At 48 months, we found higher type 2 diabetes incidence for progressively increasing number of prediabetes defects (odds ratio >2, p<0.008). In conclusion, the prediabetes groups showed differences in type/degree of glucometabolic impairment. Compared to the pooled group with isolated defects, those with double or triple defect showed progressive differences in diabetes incidence.

AB - Differences in glucose metabolism among categories of prediabetes have not been systematically investigated. In this longitudinal study, participants (N=2111) underwent 2h-75g OGTT at baseline and 48 months. HbA1c was also measured. We classified participants as having isolated prediabetes defect (impaired fasting glucose, IFG; impaired glucose tolerance, IGT; HbA1c-prediabetes, IA1c), two defects (IFG+IGT, IFG+IA1c, IGT+IA1c), or all defects (IFG+IGT+IA1c). Beta-cell function (BCF) and insulin sensitivity (IS) were assessed from OGTT. At baseline, when pooling participants with isolated defects, they showed impairment in both BCF and IS compared to healthy controls. Pooled groups with two or three defects showed progressive further deterioration. Among groups with isolated defect, IGT showed lower IS, insulin secretion at reference glucose (ISRr), and insulin secretion potentiation (p<0.002). Conversely, IA1c showed higher IS and ISRr (p<0.0001). Among groups with two defects, we similarly found differences in both BCF and IS. At 48 months, we found higher type 2 diabetes incidence for progressively increasing number of prediabetes defects (odds ratio >2, p<0.008). In conclusion, the prediabetes groups showed differences in type/degree of glucometabolic impairment. Compared to the pooled group with isolated defects, those with double or triple defect showed progressive differences in diabetes incidence.

U2 - 10.2337/db21-0227

DO - 10.2337/db21-0227

M3 - Journal article

C2 - 34233929

VL - 70

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 6

M1 - db210227

ER -

ID: 274229627