Polygenic risk provides biological validity for the ICHD-3 criteria among Finnish migraine families

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Polygenic risk provides biological validity for the ICHD-3 criteria among Finnish migraine families. / Häppölä, Paavo; Gormley, Padhraig; Nuottamo, Marjo E.; Artto, Ville; Sumelahti, Marja Liisa; Nissilä, Markku; Keski-Säntti, Petra; Ilmavirta, Matti; Kaunisto, Mari A.; Hämäläinen, Eija I.; Ripatti, Samuli; Pirinen, Matti; Wessman, Maija; Palotie, Aarno; Kallela, Mikko; International Headache Genetics Consortium (IHGC) ; Hansen, Thomas Folkmann (Member of author collaboration); Olesen, Jes (Member of author collaboration).

In: Cephalalgia, Vol. 42, No. 4-5, 2022, p. 345-356.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Häppölä, P, Gormley, P, Nuottamo, ME, Artto, V, Sumelahti, ML, Nissilä, M, Keski-Säntti, P, Ilmavirta, M, Kaunisto, MA, Hämäläinen, EI, Ripatti, S, Pirinen, M, Wessman, M, Palotie, A, Kallela, M, International Headache Genetics Consortium (IHGC), Hansen, TF & Olesen, J 2022, 'Polygenic risk provides biological validity for the ICHD-3 criteria among Finnish migraine families', Cephalalgia, vol. 42, no. 4-5, pp. 345-356. https://doi.org/10.1177/03331024211045651

APA

Häppölä, P., Gormley, P., Nuottamo, M. E., Artto, V., Sumelahti, M. L., Nissilä, M., Keski-Säntti, P., Ilmavirta, M., Kaunisto, M. A., Hämäläinen, E. I., Ripatti, S., Pirinen, M., Wessman, M., Palotie, A., Kallela, M., International Headache Genetics Consortium (IHGC), Hansen, T. F., & Olesen, J. (2022). Polygenic risk provides biological validity for the ICHD-3 criteria among Finnish migraine families. Cephalalgia, 42(4-5), 345-356. https://doi.org/10.1177/03331024211045651

Vancouver

Häppölä P, Gormley P, Nuottamo ME, Artto V, Sumelahti ML, Nissilä M et al. Polygenic risk provides biological validity for the ICHD-3 criteria among Finnish migraine families. Cephalalgia. 2022;42(4-5):345-356. https://doi.org/10.1177/03331024211045651

Author

Häppölä, Paavo ; Gormley, Padhraig ; Nuottamo, Marjo E. ; Artto, Ville ; Sumelahti, Marja Liisa ; Nissilä, Markku ; Keski-Säntti, Petra ; Ilmavirta, Matti ; Kaunisto, Mari A. ; Hämäläinen, Eija I. ; Ripatti, Samuli ; Pirinen, Matti ; Wessman, Maija ; Palotie, Aarno ; Kallela, Mikko ; International Headache Genetics Consortium (IHGC) ; Hansen, Thomas Folkmann ; Olesen, Jes. / Polygenic risk provides biological validity for the ICHD-3 criteria among Finnish migraine families. In: Cephalalgia. 2022 ; Vol. 42, No. 4-5. pp. 345-356.

Bibtex

@article{37180c05d88f4eed84461c0bea177f1a,
title = "Polygenic risk provides biological validity for the ICHD-3 criteria among Finnish migraine families",
abstract = "Background: Migraine is diagnosed using the extensively field-tested International Classification of Headache Disorders (ICHD-3) consensus criteria derived by the International Headache Society. To evaluate the criteria in respect to a measurable biomarker, we studied the relationship between the main ICHD-3 criteria and the polygenic risk score, a measure of common variant burden in migraine. Methods: We used linear mixed models to study the correlation of ICHD-3 diagnostic criteria, underlying symptoms, and main diagnoses with the polygenic risk score of migraine in a cohort of 8602 individuals from the Finnish Migraine Genome Project. Results: Main diagnostic categories and all underlying diagnostic criteria formed a consistent continuum along the increasing polygenic burden. Polygenic risk was associated with the heterogeneous clinical picture starting from the non-migraine headache (mean 0.07; 95% CI 0.02–0.12; p = 0.008 compared to the non-headache group), to probable migraine (mean 0.13; 95% CI 0.08–0.18; p < 0.001), migraine headache (mean 0.17; 95% CI 0.14–0.21; p < 0.001) and migraine with typical visual aura (mean 0.29; 95% CI 0.26–0.33; p < 0.001), all the way to the hemiplegic aura (mean 0.37; 95% CI 0.31–0.43; p < 0.001). All individual ICHD-3 symptoms and the total number of reported symptoms, a surrogate of migraine complexity, demonstrated a clear inclination with an increasing polygenic risk. Conclusions: The complex migraine phenotype progressively follows the polygenic burden from individuals with no headache to non-migrainous headache and up to patients with attacks manifesting all the features of the ICHD-3 headache and aura. Results provide further biological support for the ICHD-3 diagnostic criteria.",
keywords = "diagnosis criteria, headache, Migraine, polygenic risk score",
author = "Paavo H{\"a}pp{\"o}l{\"a} and Padhraig Gormley and Nuottamo, {Marjo E.} and Ville Artto and Sumelahti, {Marja Liisa} and Markku Nissil{\"a} and Petra Keski-S{\"a}ntti and Matti Ilmavirta and Kaunisto, {Mari A.} and H{\"a}m{\"a}l{\"a}inen, {Eija I.} and Samuli Ripatti and Matti Pirinen and Maija Wessman and Aarno Palotie and Mikko Kallela and {International Headache Genetics Consortium (IHGC)} and Hansen, {Thomas Folkmann} and Jes Olesen",
note = "Publisher Copyright: {\textcopyright} International Headache Society 2021.",
year = "2022",
doi = "10.1177/03331024211045651",
language = "English",
volume = "42",
pages = "345--356",
journal = "Cephalalgia",
issn = "0800-1952",
publisher = "SAGE Publications",
number = "4-5",

}

RIS

TY - JOUR

T1 - Polygenic risk provides biological validity for the ICHD-3 criteria among Finnish migraine families

AU - Häppölä, Paavo

AU - Gormley, Padhraig

AU - Nuottamo, Marjo E.

AU - Artto, Ville

AU - Sumelahti, Marja Liisa

AU - Nissilä, Markku

AU - Keski-Säntti, Petra

AU - Ilmavirta, Matti

AU - Kaunisto, Mari A.

AU - Hämäläinen, Eija I.

AU - Ripatti, Samuli

AU - Pirinen, Matti

AU - Wessman, Maija

AU - Palotie, Aarno

AU - Kallela, Mikko

AU - International Headache Genetics Consortium (IHGC)

A2 - Hansen, Thomas Folkmann

A2 - Olesen, Jes

N1 - Publisher Copyright: © International Headache Society 2021.

PY - 2022

Y1 - 2022

N2 - Background: Migraine is diagnosed using the extensively field-tested International Classification of Headache Disorders (ICHD-3) consensus criteria derived by the International Headache Society. To evaluate the criteria in respect to a measurable biomarker, we studied the relationship between the main ICHD-3 criteria and the polygenic risk score, a measure of common variant burden in migraine. Methods: We used linear mixed models to study the correlation of ICHD-3 diagnostic criteria, underlying symptoms, and main diagnoses with the polygenic risk score of migraine in a cohort of 8602 individuals from the Finnish Migraine Genome Project. Results: Main diagnostic categories and all underlying diagnostic criteria formed a consistent continuum along the increasing polygenic burden. Polygenic risk was associated with the heterogeneous clinical picture starting from the non-migraine headache (mean 0.07; 95% CI 0.02–0.12; p = 0.008 compared to the non-headache group), to probable migraine (mean 0.13; 95% CI 0.08–0.18; p < 0.001), migraine headache (mean 0.17; 95% CI 0.14–0.21; p < 0.001) and migraine with typical visual aura (mean 0.29; 95% CI 0.26–0.33; p < 0.001), all the way to the hemiplegic aura (mean 0.37; 95% CI 0.31–0.43; p < 0.001). All individual ICHD-3 symptoms and the total number of reported symptoms, a surrogate of migraine complexity, demonstrated a clear inclination with an increasing polygenic risk. Conclusions: The complex migraine phenotype progressively follows the polygenic burden from individuals with no headache to non-migrainous headache and up to patients with attacks manifesting all the features of the ICHD-3 headache and aura. Results provide further biological support for the ICHD-3 diagnostic criteria.

AB - Background: Migraine is diagnosed using the extensively field-tested International Classification of Headache Disorders (ICHD-3) consensus criteria derived by the International Headache Society. To evaluate the criteria in respect to a measurable biomarker, we studied the relationship between the main ICHD-3 criteria and the polygenic risk score, a measure of common variant burden in migraine. Methods: We used linear mixed models to study the correlation of ICHD-3 diagnostic criteria, underlying symptoms, and main diagnoses with the polygenic risk score of migraine in a cohort of 8602 individuals from the Finnish Migraine Genome Project. Results: Main diagnostic categories and all underlying diagnostic criteria formed a consistent continuum along the increasing polygenic burden. Polygenic risk was associated with the heterogeneous clinical picture starting from the non-migraine headache (mean 0.07; 95% CI 0.02–0.12; p = 0.008 compared to the non-headache group), to probable migraine (mean 0.13; 95% CI 0.08–0.18; p < 0.001), migraine headache (mean 0.17; 95% CI 0.14–0.21; p < 0.001) and migraine with typical visual aura (mean 0.29; 95% CI 0.26–0.33; p < 0.001), all the way to the hemiplegic aura (mean 0.37; 95% CI 0.31–0.43; p < 0.001). All individual ICHD-3 symptoms and the total number of reported symptoms, a surrogate of migraine complexity, demonstrated a clear inclination with an increasing polygenic risk. Conclusions: The complex migraine phenotype progressively follows the polygenic burden from individuals with no headache to non-migrainous headache and up to patients with attacks manifesting all the features of the ICHD-3 headache and aura. Results provide further biological support for the ICHD-3 diagnostic criteria.

KW - diagnosis criteria

KW - headache

KW - Migraine

KW - polygenic risk score

U2 - 10.1177/03331024211045651

DO - 10.1177/03331024211045651

M3 - Journal article

C2 - 34648375

AN - SCOPUS:85121449031

VL - 42

SP - 345

EP - 356

JO - Cephalalgia

JF - Cephalalgia

SN - 0800-1952

IS - 4-5

ER -

ID: 346458455