Pharos: Collating protein information to shed light on the druggable genome
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Pharos : Collating protein information to shed light on the druggable genome. / Nguyen, Dac-Trung; Mathias, Stephen; Bologa, Cristian; Brunak, Soren; Fernandez, Nicolas; Gaulton, Anna; Hersey, Anne; Holmes, Jayme; Jensen, Lars Juhl; Karlsson, Anneli; Liu, Guixia; Ma'ayan, Avi; Mandava, Geetha; Mani, Subramani; Mehta, Saurabh; Overington, John; Patel, Juhee; Rouillard, Andrew D; Schürer, Stephan; Sheils, Timothy; Simeonov, Anton; Sklar, Larry A; Southall, Noel; Ursu, Oleg; Vidovic, Dusica; Waller, Anna; Yang, Jeremy; Jadhav, Ajit; Oprea, Tudor I; Guha, Rajarshi.
In: Nucleic Acids Research, Vol. 45, No. D1, 01.2017, p. D995–D1002.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Pharos
T2 - Collating protein information to shed light on the druggable genome
AU - Nguyen, Dac-Trung
AU - Mathias, Stephen
AU - Bologa, Cristian
AU - Brunak, Soren
AU - Fernandez, Nicolas
AU - Gaulton, Anna
AU - Hersey, Anne
AU - Holmes, Jayme
AU - Jensen, Lars Juhl
AU - Karlsson, Anneli
AU - Liu, Guixia
AU - Ma'ayan, Avi
AU - Mandava, Geetha
AU - Mani, Subramani
AU - Mehta, Saurabh
AU - Overington, John
AU - Patel, Juhee
AU - Rouillard, Andrew D
AU - Schürer, Stephan
AU - Sheils, Timothy
AU - Simeonov, Anton
AU - Sklar, Larry A
AU - Southall, Noel
AU - Ursu, Oleg
AU - Vidovic, Dusica
AU - Waller, Anna
AU - Yang, Jeremy
AU - Jadhav, Ajit
AU - Oprea, Tudor I
AU - Guha, Rajarshi
N1 - Published by Oxford University Press on behalf of Nucleic Acids Research 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US.
PY - 2017/1
Y1 - 2017/1
N2 - The 'druggable genome' encompasses several protein families, but only a subset of targets within them have attracted significant research attention and thus have information about them publicly available. The Illuminating the Druggable Genome (IDG) program was initiated in 2014, has the goal of developing experimental techniques and a Knowledge Management Center (KMC) that would collect and organize information about protein targets from four families, representing the most common druggable targets with an emphasis on understudied proteins. Here, we describe two resources developed by the KMC: the Target Central Resource Database (TCRD) which collates many heterogeneous gene/protein datasets and Pharos (https://pharos.nih.gov), a multimodal web interface that presents the data from TCRD. We briefly describe the types and sources of data considered by the KMC and then highlight features of the Pharos interface designed to enable intuitive access to the IDG knowledgebase. The aim of Pharos is to encourage 'serendipitous browsing', whereby related, relevant information is made easily discoverable. We conclude by describing two use cases that highlight the utility of Pharos and TCRD.
AB - The 'druggable genome' encompasses several protein families, but only a subset of targets within them have attracted significant research attention and thus have information about them publicly available. The Illuminating the Druggable Genome (IDG) program was initiated in 2014, has the goal of developing experimental techniques and a Knowledge Management Center (KMC) that would collect and organize information about protein targets from four families, representing the most common druggable targets with an emphasis on understudied proteins. Here, we describe two resources developed by the KMC: the Target Central Resource Database (TCRD) which collates many heterogeneous gene/protein datasets and Pharos (https://pharos.nih.gov), a multimodal web interface that presents the data from TCRD. We briefly describe the types and sources of data considered by the KMC and then highlight features of the Pharos interface designed to enable intuitive access to the IDG knowledgebase. The aim of Pharos is to encourage 'serendipitous browsing', whereby related, relevant information is made easily discoverable. We conclude by describing two use cases that highlight the utility of Pharos and TCRD.
U2 - 10.1093/nar/gkw1072
DO - 10.1093/nar/gkw1072
M3 - Journal article
C2 - 27903890
VL - 45
SP - D995–D1002
JO - Nucleic Acids Research
JF - Nucleic Acids Research
SN - 0305-1048
IS - D1
ER -
ID: 169733586