Oxyntomodulin: actions and role in diabetes
Research output: Contribution to journal › Review › Research › peer-review
Oxyntomodulin is a product of the glucagon precursor, proglucagon, produced and released from the endocrine L-cells of the gut after enzymatic processing by the precursor prohormone convertase 1/3. It corresponds to the proglucagon sequence 33-69 and thus contains the entire glucagon sequence plus a C-terminal octapeptide, comprising in total 37 amino acids. As might have been expected, it has glucagon-like bioactivity, but also and more surprisingly also activates the receptor for GLP-1. This has given the molecule an interesting status as a glucagon-GLP-1 co-agonist, which is currently attracting considerable interest for its potential in the treatment of diabetes and obesity. Here, we provide an update on oxyntomodulin with a focus on its potential role in metabolic diseases.
Original language | English |
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Journal | Peptides |
Volume | 100 |
Pages (from-to) | 48-53 |
Number of pages | 6 |
ISSN | 0196-9781 |
DOIs | |
Publication status | Published - 2018 |
- Journal Article, Review, Diabetes, Oxyntomodulin, Proglucagon
Research areas
ID: 189765037