Obesity variants in the GIPR gene do not associate with risk of fracture or bone mineral density

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Obesity variants in the GIPR gene do not associate with risk of fracture or bone mineral density. / Styrkarsdottir, Unnur; Tragante, Vinicius; Stefansdottir, Lilja; Thorleifsson, Gudmar; Oddsson, Asmundur; Sørensen, Erik; Erikstrup, Christian; Schwarz, Peter; Jørgensen, Henrik Løvendahl; Lauritzen, Jes Bruun; Brunak, Søren; Knowlton, Kirk U; Nadauld, Lincoln D; Ullum, Henrik; Pedersen, Ole Birger Vesterager; Ostrowski, Sisse Rye; Holm, Hilma; Gudbjartsson, Daniel F; Sulem, Patrick; Stefansson, Kari.

In: Journal of Clinical Endocrinology and Metabolism, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Styrkarsdottir, U, Tragante, V, Stefansdottir, L, Thorleifsson, G, Oddsson, A, Sørensen, E, Erikstrup, C, Schwarz, P, Jørgensen, HL, Lauritzen, JB, Brunak, S, Knowlton, KU, Nadauld, LD, Ullum, H, Pedersen, OBV, Ostrowski, SR, Holm, H, Gudbjartsson, DF, Sulem, P & Stefansson, K 2023, 'Obesity variants in the GIPR gene do not associate with risk of fracture or bone mineral density', Journal of Clinical Endocrinology and Metabolism. https://doi.org/10.1210/clinem/dgad734

APA

Styrkarsdottir, U., Tragante, V., Stefansdottir, L., Thorleifsson, G., Oddsson, A., Sørensen, E., Erikstrup, C., Schwarz, P., Jørgensen, H. L., Lauritzen, J. B., Brunak, S., Knowlton, K. U., Nadauld, L. D., Ullum, H., Pedersen, O. B. V., Ostrowski, S. R., Holm, H., Gudbjartsson, D. F., Sulem, P., & Stefansson, K. (2023). Obesity variants in the GIPR gene do not associate with risk of fracture or bone mineral density. Journal of Clinical Endocrinology and Metabolism. https://doi.org/10.1210/clinem/dgad734

Vancouver

Styrkarsdottir U, Tragante V, Stefansdottir L, Thorleifsson G, Oddsson A, Sørensen E et al. Obesity variants in the GIPR gene do not associate with risk of fracture or bone mineral density. Journal of Clinical Endocrinology and Metabolism. 2023. https://doi.org/10.1210/clinem/dgad734

Author

Styrkarsdottir, Unnur ; Tragante, Vinicius ; Stefansdottir, Lilja ; Thorleifsson, Gudmar ; Oddsson, Asmundur ; Sørensen, Erik ; Erikstrup, Christian ; Schwarz, Peter ; Jørgensen, Henrik Løvendahl ; Lauritzen, Jes Bruun ; Brunak, Søren ; Knowlton, Kirk U ; Nadauld, Lincoln D ; Ullum, Henrik ; Pedersen, Ole Birger Vesterager ; Ostrowski, Sisse Rye ; Holm, Hilma ; Gudbjartsson, Daniel F ; Sulem, Patrick ; Stefansson, Kari. / Obesity variants in the GIPR gene do not associate with risk of fracture or bone mineral density. In: Journal of Clinical Endocrinology and Metabolism. 2023.

Bibtex

@article{ba322eea8a2245c3b36631167ba0dd57,
title = "Obesity variants in the GIPR gene do not associate with risk of fracture or bone mineral density",
abstract = "OBJECTIVE: The objective of this study was to investigate the risk of fracture and bone mineral density (BMD) of sequence variants in GIPR that reduce the activity of the GIPR receptor and have been associated with reduced body mass index (BMI).METHODS: We analysed the association of three missense variants in GIPR, a common variant, rs1800437 (p.Glu354Gln), and two rare variants, rs139215588 (p.Arg190Gln) and rs143430880 (p.Glu288Gly), as well as a burden of predicted loss of function (LoF) variants with risk of fracture and with BMD in a large meta-analysis of up to 1.2 million participants. We analysed associations with fractures at different skeletal sites in the general population; any fractures, hip fractures, vertebral fractures and forearm fractures, and specifically non-vertebral and osteoporotic fractures in postmenopausal women. We also evaluated associations with BMD at the lumbar spine, femoral neck, and total body measured with dual-energy X-ray absorptiometry (DXA), and with BMD estimated from heel ultrasound (eBMD).RESULTS: None of the three missense variants in GIPR associated significantly with increased risk of fractures or with lower BMD. Burden of LoF variants in GIPR were not associated with fractures or with BMD measured with clinically validated DXA, but associated with eBMD.CONCLUSION: Missense variants in GIPR, or burden of LoF variants in the gene, do not associate with risk of fractures or with lower BMD.",
author = "Unnur Styrkarsdottir and Vinicius Tragante and Lilja Stefansdottir and Gudmar Thorleifsson and Asmundur Oddsson and Erik S{\o}rensen and Christian Erikstrup and Peter Schwarz and J{\o}rgensen, {Henrik L{\o}vendahl} and Lauritzen, {Jes Bruun} and S{\o}ren Brunak and Knowlton, {Kirk U} and Nadauld, {Lincoln D} and Henrik Ullum and Pedersen, {Ole Birger Vesterager} and Ostrowski, {Sisse Rye} and Hilma Holm and Gudbjartsson, {Daniel F} and Patrick Sulem and Kari Stefansson",
note = "{\textcopyright} The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society.",
year = "2023",
doi = "10.1210/clinem/dgad734",
language = "English",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "Oxford University Press",

}

RIS

TY - JOUR

T1 - Obesity variants in the GIPR gene do not associate with risk of fracture or bone mineral density

AU - Styrkarsdottir, Unnur

AU - Tragante, Vinicius

AU - Stefansdottir, Lilja

AU - Thorleifsson, Gudmar

AU - Oddsson, Asmundur

AU - Sørensen, Erik

AU - Erikstrup, Christian

AU - Schwarz, Peter

AU - Jørgensen, Henrik Løvendahl

AU - Lauritzen, Jes Bruun

AU - Brunak, Søren

AU - Knowlton, Kirk U

AU - Nadauld, Lincoln D

AU - Ullum, Henrik

AU - Pedersen, Ole Birger Vesterager

AU - Ostrowski, Sisse Rye

AU - Holm, Hilma

AU - Gudbjartsson, Daniel F

AU - Sulem, Patrick

AU - Stefansson, Kari

N1 - © The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society.

PY - 2023

Y1 - 2023

N2 - OBJECTIVE: The objective of this study was to investigate the risk of fracture and bone mineral density (BMD) of sequence variants in GIPR that reduce the activity of the GIPR receptor and have been associated with reduced body mass index (BMI).METHODS: We analysed the association of three missense variants in GIPR, a common variant, rs1800437 (p.Glu354Gln), and two rare variants, rs139215588 (p.Arg190Gln) and rs143430880 (p.Glu288Gly), as well as a burden of predicted loss of function (LoF) variants with risk of fracture and with BMD in a large meta-analysis of up to 1.2 million participants. We analysed associations with fractures at different skeletal sites in the general population; any fractures, hip fractures, vertebral fractures and forearm fractures, and specifically non-vertebral and osteoporotic fractures in postmenopausal women. We also evaluated associations with BMD at the lumbar spine, femoral neck, and total body measured with dual-energy X-ray absorptiometry (DXA), and with BMD estimated from heel ultrasound (eBMD).RESULTS: None of the three missense variants in GIPR associated significantly with increased risk of fractures or with lower BMD. Burden of LoF variants in GIPR were not associated with fractures or with BMD measured with clinically validated DXA, but associated with eBMD.CONCLUSION: Missense variants in GIPR, or burden of LoF variants in the gene, do not associate with risk of fractures or with lower BMD.

AB - OBJECTIVE: The objective of this study was to investigate the risk of fracture and bone mineral density (BMD) of sequence variants in GIPR that reduce the activity of the GIPR receptor and have been associated with reduced body mass index (BMI).METHODS: We analysed the association of three missense variants in GIPR, a common variant, rs1800437 (p.Glu354Gln), and two rare variants, rs139215588 (p.Arg190Gln) and rs143430880 (p.Glu288Gly), as well as a burden of predicted loss of function (LoF) variants with risk of fracture and with BMD in a large meta-analysis of up to 1.2 million participants. We analysed associations with fractures at different skeletal sites in the general population; any fractures, hip fractures, vertebral fractures and forearm fractures, and specifically non-vertebral and osteoporotic fractures in postmenopausal women. We also evaluated associations with BMD at the lumbar spine, femoral neck, and total body measured with dual-energy X-ray absorptiometry (DXA), and with BMD estimated from heel ultrasound (eBMD).RESULTS: None of the three missense variants in GIPR associated significantly with increased risk of fractures or with lower BMD. Burden of LoF variants in GIPR were not associated with fractures or with BMD measured with clinically validated DXA, but associated with eBMD.CONCLUSION: Missense variants in GIPR, or burden of LoF variants in the gene, do not associate with risk of fractures or with lower BMD.

U2 - 10.1210/clinem/dgad734

DO - 10.1210/clinem/dgad734

M3 - Journal article

C2 - 38118020

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

ER -

ID: 378866838