Molecular analysis of primary melanoma T cells identifies patients at risk for metastatic recurrence

Research output: Contribution to journal › Journal article › Research › peer-review

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Molecular analysis of primary melanoma T cells identifies patients at risk for metastatic recurrence. / Pruessmann, Wiebke; Rytlewski, Julie; Wilmott, James; Mihm, Martin C.; Attrill, Grace H.; Dyring-Andersen, Beatrice; Fields, Paul; Zhan, Qian; Colebatch, Andrew J.; Ferguson, Peter M.; Thompson, John F.; Kallenbach, Klaus; Yusko, Erik; Clark, Rachael A.; Robins, Harlan; Scolyer, Richard A.; Kupper, Thomas S.

In: Nature cancer, Vol. 1, No. 2, 2020, p. 197-209.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Pruessmann, W, Rytlewski, J, Wilmott, J, Mihm, MC, Attrill, GH, Dyring-Andersen, B, Fields, P, Zhan, Q, Colebatch, AJ, Ferguson, PM, Thompson, JF, Kallenbach, K, Yusko, E, Clark, RA, Robins, H, Scolyer, RA & Kupper, TS 2020, 'Molecular analysis of primary melanoma T cells identifies patients at risk for metastatic recurrence', Nature cancer, vol. 1, no. 2, pp. 197-209. https://doi.org/10.1038/s43018-019-0019-5

APA

Pruessmann, W., Rytlewski, J., Wilmott, J., Mihm, M. C., Attrill, G. H., Dyring-Andersen, B., Fields, P., Zhan, Q., Colebatch, A. J., Ferguson, P. M., Thompson, J. F., Kallenbach, K., Yusko, E., Clark, R. A., Robins, H., Scolyer, R. A., & Kupper, T. S. (2020). Molecular analysis of primary melanoma T cells identifies patients at risk for metastatic recurrence. Nature cancer, 1(2), 197-209. https://doi.org/10.1038/s43018-019-0019-5

Vancouver

Pruessmann W, Rytlewski J, Wilmott J, Mihm MC, Attrill GH, Dyring-Andersen B et al. Molecular analysis of primary melanoma T cells identifies patients at risk for metastatic recurrence. Nature cancer. 2020;1(2):197-209. https://doi.org/10.1038/s43018-019-0019-5

Author

Pruessmann, Wiebke ; Rytlewski, Julie ; Wilmott, James ; Mihm, Martin C. ; Attrill, Grace H. ; Dyring-Andersen, Beatrice ; Fields, Paul ; Zhan, Qian ; Colebatch, Andrew J. ; Ferguson, Peter M. ; Thompson, John F. ; Kallenbach, Klaus ; Yusko, Erik ; Clark, Rachael A. ; Robins, Harlan ; Scolyer, Richard A. ; Kupper, Thomas S. / Molecular analysis of primary melanoma T cells identifies patients at risk for metastatic recurrence. In: Nature cancer. 2020 ; Vol. 1, No. 2. pp. 197-209.

Bibtex

@article{31b24d5b3b3f4144893079960941f5e6,
title = "Molecular analysis of primary melanoma T cells identifies patients at risk for metastatic recurrence",
abstract = "Primary melanomas >1 mm thickness are potentially curable by resection, but can recur metastatically. We assessed the prognostic value of the T-cell fraction (TCFr) and repertoire T-cell clonality, measured by high-throughput sequencing of the T-cell receptor beta-chain in T2-T4 primary melanomas (n = 199). TCFr accurately predicted progression-free survival and was independent of thickness, ulceration, mitotic rate and age. TCFr was second only to tumor thickness in its predictive value, using a gradient-boosted model. For accurate progression-free survival prediction, adding TCFr to tumor thickness was superior to adding any other histopathological variable. Furthermore, a TCFr >20% was protective regardless of tumor ulceration status, mitotic rate or presence of nodal disease. TCFr is a quantitative molecular assessment that predicts metastatic recurrence in primary melanoma patients whose disease has been resected surgically. The present study suggests that a successful T-cell-mediated, antitumour response can be present in primary melanomas.",
keywords = "TUMOR-INFILTRATING LYMPHOCYTES, CUTANEOUS MELANOMA, MALIGNANT-MELANOMA, PROGNOSTIC VALUE, CTLA-4 BLOCKADE, NODE STATUS, SURVIVAL, IPILIMUMAB, PREDICTION, CANCER",
author = "Wiebke Pruessmann and Julie Rytlewski and James Wilmott and Mihm, {Martin C.} and Attrill, {Grace H.} and Beatrice Dyring-Andersen and Paul Fields and Qian Zhan and Colebatch, {Andrew J.} and Ferguson, {Peter M.} and Thompson, {John F.} and Klaus Kallenbach and Erik Yusko and Clark, {Rachael A.} and Harlan Robins and Scolyer, {Richard A.} and Kupper, {Thomas S.}",
year = "2020",
doi = "10.1038/s43018-019-0019-5",
language = "English",
volume = "1",
pages = "197--209",
journal = "Nature cancer",
publisher = "SPRINGERNATURE",
number = "2",

}

RIS

TY - JOUR

T1 - Molecular analysis of primary melanoma T cells identifies patients at risk for metastatic recurrence

AU - Pruessmann, Wiebke

AU - Rytlewski, Julie

AU - Wilmott, James

AU - Mihm, Martin C.

AU - Attrill, Grace H.

AU - Dyring-Andersen, Beatrice

AU - Fields, Paul

AU - Zhan, Qian

AU - Colebatch, Andrew J.

AU - Ferguson, Peter M.

AU - Thompson, John F.

AU - Kallenbach, Klaus

AU - Yusko, Erik

AU - Clark, Rachael A.

AU - Robins, Harlan

AU - Scolyer, Richard A.

AU - Kupper, Thomas S.

PY - 2020

Y1 - 2020

N2 - Primary melanomas >1 mm thickness are potentially curable by resection, but can recur metastatically. We assessed the prognostic value of the T-cell fraction (TCFr) and repertoire T-cell clonality, measured by high-throughput sequencing of the T-cell receptor beta-chain in T2-T4 primary melanomas (n = 199). TCFr accurately predicted progression-free survival and was independent of thickness, ulceration, mitotic rate and age. TCFr was second only to tumor thickness in its predictive value, using a gradient-boosted model. For accurate progression-free survival prediction, adding TCFr to tumor thickness was superior to adding any other histopathological variable. Furthermore, a TCFr >20% was protective regardless of tumor ulceration status, mitotic rate or presence of nodal disease. TCFr is a quantitative molecular assessment that predicts metastatic recurrence in primary melanoma patients whose disease has been resected surgically. The present study suggests that a successful T-cell-mediated, antitumour response can be present in primary melanomas.

AB - Primary melanomas >1 mm thickness are potentially curable by resection, but can recur metastatically. We assessed the prognostic value of the T-cell fraction (TCFr) and repertoire T-cell clonality, measured by high-throughput sequencing of the T-cell receptor beta-chain in T2-T4 primary melanomas (n = 199). TCFr accurately predicted progression-free survival and was independent of thickness, ulceration, mitotic rate and age. TCFr was second only to tumor thickness in its predictive value, using a gradient-boosted model. For accurate progression-free survival prediction, adding TCFr to tumor thickness was superior to adding any other histopathological variable. Furthermore, a TCFr >20% was protective regardless of tumor ulceration status, mitotic rate or presence of nodal disease. TCFr is a quantitative molecular assessment that predicts metastatic recurrence in primary melanoma patients whose disease has been resected surgically. The present study suggests that a successful T-cell-mediated, antitumour response can be present in primary melanomas.

KW - TUMOR-INFILTRATING LYMPHOCYTES

KW - CUTANEOUS MELANOMA

KW - MALIGNANT-MELANOMA

KW - PROGNOSTIC VALUE

KW - CTLA-4 BLOCKADE

KW - NODE STATUS

KW - SURVIVAL

KW - IPILIMUMAB

KW - PREDICTION

KW - CANCER

U2 - 10.1038/s43018-019-0019-5

DO - 10.1038/s43018-019-0019-5

M3 - Journal article

C2 - 33305293

VL - 1

SP - 197

EP - 209

JO - Nature cancer

JF - Nature cancer

IS - 2

ER -

ID: 257193047