MiT/TFEfactors controlER-phagy via transcriptional regulation ofFAM134B

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

MiT/TFEfactors controlER-phagy via transcriptional regulation ofFAM134B. / Cinque, Laura; De Leonibus, Chiara; Iavazzo, Maria; Krahmer, Natalie; Intartaglia, Daniela; Salierno, Francesco Giuseppe; De Cegli, Rossella; Di Malta, Chiara; Svelto, Maria; Lanzara, Carmela; Maddaluno, Marianna; Wanderlingh, Luca Giorgio; Huebner, Antje K.; Cesana, Marcella; Bonn, Florian; Polishchuk, Elena; Huebner, Christian A.; Conte, Ivan; Dikic, Ivan; Mann, Matthias; Ballabio, Andrea; Sacco, Francesca; Grumati, Paolo; Settembre, Carmine.

In: EMBO Journal, Vol. 39, No. 17, 105696, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Cinque, L, De Leonibus, C, Iavazzo, M, Krahmer, N, Intartaglia, D, Salierno, FG, De Cegli, R, Di Malta, C, Svelto, M, Lanzara, C, Maddaluno, M, Wanderlingh, LG, Huebner, AK, Cesana, M, Bonn, F, Polishchuk, E, Huebner, CA, Conte, I, Dikic, I, Mann, M, Ballabio, A, Sacco, F, Grumati, P & Settembre, C 2020, 'MiT/TFEfactors controlER-phagy via transcriptional regulation ofFAM134B', EMBO Journal, vol. 39, no. 17, 105696. https://doi.org/10.15252/embj.2020105696

APA

Cinque, L., De Leonibus, C., Iavazzo, M., Krahmer, N., Intartaglia, D., Salierno, F. G., De Cegli, R., Di Malta, C., Svelto, M., Lanzara, C., Maddaluno, M., Wanderlingh, L. G., Huebner, A. K., Cesana, M., Bonn, F., Polishchuk, E., Huebner, C. A., Conte, I., Dikic, I., ... Settembre, C. (2020). MiT/TFEfactors controlER-phagy via transcriptional regulation ofFAM134B. EMBO Journal, 39(17), [105696]. https://doi.org/10.15252/embj.2020105696

Vancouver

Cinque L, De Leonibus C, Iavazzo M, Krahmer N, Intartaglia D, Salierno FG et al. MiT/TFEfactors controlER-phagy via transcriptional regulation ofFAM134B. EMBO Journal. 2020;39(17). 105696. https://doi.org/10.15252/embj.2020105696

Author

Cinque, Laura ; De Leonibus, Chiara ; Iavazzo, Maria ; Krahmer, Natalie ; Intartaglia, Daniela ; Salierno, Francesco Giuseppe ; De Cegli, Rossella ; Di Malta, Chiara ; Svelto, Maria ; Lanzara, Carmela ; Maddaluno, Marianna ; Wanderlingh, Luca Giorgio ; Huebner, Antje K. ; Cesana, Marcella ; Bonn, Florian ; Polishchuk, Elena ; Huebner, Christian A. ; Conte, Ivan ; Dikic, Ivan ; Mann, Matthias ; Ballabio, Andrea ; Sacco, Francesca ; Grumati, Paolo ; Settembre, Carmine. / MiT/TFEfactors controlER-phagy via transcriptional regulation ofFAM134B. In: EMBO Journal. 2020 ; Vol. 39, No. 17.

Bibtex

@article{12f964d3227e41deac4a79499d43513a,
title = "MiT/TFEfactors controlER-phagy via transcriptional regulation ofFAM134B",
abstract = "Lysosomal degradation of the endoplasmic reticulum (ER) via autophagy (ER-phagy) is emerging as a critical regulator of cell homeostasis and function. The recent identification ofER-phagy receptors has shed light on the molecular mechanisms underlining this process. However, the signaling pathways regulatingER-phagy in response to cellular needs are still largely unknown. We found that the nutrient responsive transcription factorsTFEBandTFE3-master regulators of lysosomal biogenesis and autophagy-controlER-phagy by inducing the expression of theER-phagy receptorFAM134B. TheTFEB/TFE3-FAM134B axis promotesER-phagy activation upon prolonged starvation. In addition, this pathway is activated in chondrocytes byFGFsignaling, a critical regulator of skeletal growth.FGFsignaling inducesJNK-dependent proteasomal degradation of the insulin receptor substrate 1 (IRS1), which in turn inhibits thePI3K-PKB/Akt-mTORC1 pathway and promotesTFEB/TFE3 nuclear translocation and enhancesFAM134B transcription. Notably,FAM134B is required for protein secretion in chondrocytes, and cartilage growth and bone mineralization in medaka fish. This study identifies a new signaling pathway that allowsER-phagy to respond to both metabolic and developmental cues.",
keywords = "ER-phagy, Fam134B, FGFsignaling, IRS1, PI3K signaling, TFEB, ENDOPLASMIC-RETICULUM, BONE-GROWTH, ER-PHAGY, AUTOPHAGY, RECEPTOR, MECHANISM, NETWORK, TEX264, FGF",
author = "Laura Cinque and {De Leonibus}, Chiara and Maria Iavazzo and Natalie Krahmer and Daniela Intartaglia and Salierno, {Francesco Giuseppe} and {De Cegli}, Rossella and {Di Malta}, Chiara and Maria Svelto and Carmela Lanzara and Marianna Maddaluno and Wanderlingh, {Luca Giorgio} and Huebner, {Antje K.} and Marcella Cesana and Florian Bonn and Elena Polishchuk and Huebner, {Christian A.} and Ivan Conte and Ivan Dikic and Matthias Mann and Andrea Ballabio and Francesca Sacco and Paolo Grumati and Carmine Settembre",
year = "2020",
doi = "10.15252/embj.2020105696",
language = "English",
volume = "39",
journal = "E M B O Journal",
issn = "0261-4189",
publisher = "Wiley-Blackwell",
number = "17",

}

RIS

TY - JOUR

T1 - MiT/TFEfactors controlER-phagy via transcriptional regulation ofFAM134B

AU - Cinque, Laura

AU - De Leonibus, Chiara

AU - Iavazzo, Maria

AU - Krahmer, Natalie

AU - Intartaglia, Daniela

AU - Salierno, Francesco Giuseppe

AU - De Cegli, Rossella

AU - Di Malta, Chiara

AU - Svelto, Maria

AU - Lanzara, Carmela

AU - Maddaluno, Marianna

AU - Wanderlingh, Luca Giorgio

AU - Huebner, Antje K.

AU - Cesana, Marcella

AU - Bonn, Florian

AU - Polishchuk, Elena

AU - Huebner, Christian A.

AU - Conte, Ivan

AU - Dikic, Ivan

AU - Mann, Matthias

AU - Ballabio, Andrea

AU - Sacco, Francesca

AU - Grumati, Paolo

AU - Settembre, Carmine

PY - 2020

Y1 - 2020

N2 - Lysosomal degradation of the endoplasmic reticulum (ER) via autophagy (ER-phagy) is emerging as a critical regulator of cell homeostasis and function. The recent identification ofER-phagy receptors has shed light on the molecular mechanisms underlining this process. However, the signaling pathways regulatingER-phagy in response to cellular needs are still largely unknown. We found that the nutrient responsive transcription factorsTFEBandTFE3-master regulators of lysosomal biogenesis and autophagy-controlER-phagy by inducing the expression of theER-phagy receptorFAM134B. TheTFEB/TFE3-FAM134B axis promotesER-phagy activation upon prolonged starvation. In addition, this pathway is activated in chondrocytes byFGFsignaling, a critical regulator of skeletal growth.FGFsignaling inducesJNK-dependent proteasomal degradation of the insulin receptor substrate 1 (IRS1), which in turn inhibits thePI3K-PKB/Akt-mTORC1 pathway and promotesTFEB/TFE3 nuclear translocation and enhancesFAM134B transcription. Notably,FAM134B is required for protein secretion in chondrocytes, and cartilage growth and bone mineralization in medaka fish. This study identifies a new signaling pathway that allowsER-phagy to respond to both metabolic and developmental cues.

AB - Lysosomal degradation of the endoplasmic reticulum (ER) via autophagy (ER-phagy) is emerging as a critical regulator of cell homeostasis and function. The recent identification ofER-phagy receptors has shed light on the molecular mechanisms underlining this process. However, the signaling pathways regulatingER-phagy in response to cellular needs are still largely unknown. We found that the nutrient responsive transcription factorsTFEBandTFE3-master regulators of lysosomal biogenesis and autophagy-controlER-phagy by inducing the expression of theER-phagy receptorFAM134B. TheTFEB/TFE3-FAM134B axis promotesER-phagy activation upon prolonged starvation. In addition, this pathway is activated in chondrocytes byFGFsignaling, a critical regulator of skeletal growth.FGFsignaling inducesJNK-dependent proteasomal degradation of the insulin receptor substrate 1 (IRS1), which in turn inhibits thePI3K-PKB/Akt-mTORC1 pathway and promotesTFEB/TFE3 nuclear translocation and enhancesFAM134B transcription. Notably,FAM134B is required for protein secretion in chondrocytes, and cartilage growth and bone mineralization in medaka fish. This study identifies a new signaling pathway that allowsER-phagy to respond to both metabolic and developmental cues.

KW - ER-phagy

KW - Fam134B

KW - FGFsignaling

KW - IRS1

KW - PI3K signaling

KW - TFEB

KW - ENDOPLASMIC-RETICULUM

KW - BONE-GROWTH

KW - ER-PHAGY

KW - AUTOPHAGY

KW - RECEPTOR

KW - MECHANISM

KW - NETWORK

KW - TEX264

KW - FGF

U2 - 10.15252/embj.2020105696

DO - 10.15252/embj.2020105696

M3 - Journal article

C2 - 32716134

VL - 39

JO - E M B O Journal

JF - E M B O Journal

SN - 0261-4189

IS - 17

M1 - 105696

ER -

ID: 250122762