Large-scale prediction of drug-target relationships
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Large-scale prediction of drug-target relationships. / Kuhn, Michael; Campillos, Mónica; González, Paula; Jensen, Lars Juhl; Bork, Peer.
In: F E B S Letters, Vol. 582, No. 8, 2008, p. 1283-90.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Large-scale prediction of drug-target relationships
AU - Kuhn, Michael
AU - Campillos, Mónica
AU - González, Paula
AU - Jensen, Lars Juhl
AU - Bork, Peer
PY - 2008
Y1 - 2008
N2 - The rapidly increasing amount of publicly available knowledge in biology and chemistry enables scientists to revisit many open problems by the systematic integration and analysis of heterogeneous novel data. The integration of relevant data does not only allow analyses at the network level, but also provides a more global view on drug-target relations. Here we review recent attempts to apply large-scale computational analyses to predict novel interactions of drugs and targets from molecular and cellular features. In this context, we quantify the family-dependent probability of two proteins to bind the same ligand as function of their sequence similarity. We finally discuss how phenotypic data could help to expand our understanding of the complex mechanisms of drug action.
AB - The rapidly increasing amount of publicly available knowledge in biology and chemistry enables scientists to revisit many open problems by the systematic integration and analysis of heterogeneous novel data. The integration of relevant data does not only allow analyses at the network level, but also provides a more global view on drug-target relations. Here we review recent attempts to apply large-scale computational analyses to predict novel interactions of drugs and targets from molecular and cellular features. In this context, we quantify the family-dependent probability of two proteins to bind the same ligand as function of their sequence similarity. We finally discuss how phenotypic data could help to expand our understanding of the complex mechanisms of drug action.
KW - Pharmaceutical Preparations
KW - Proteins
U2 - 10.1016/j.febslet.2008.02.024
DO - 10.1016/j.febslet.2008.02.024
M3 - Journal article
C2 - 18291108
VL - 582
SP - 1283
EP - 1290
JO - F E B S Letters
JF - F E B S Letters
SN - 0014-5793
IS - 8
ER -
ID: 40740103