Interleukin-6 Delays Gastric Emptying in Humans with Direct Effects on Glycemic Control

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Interleukin-6 Delays Gastric Emptying in Humans with Direct Effects on Glycemic Control. / Lehrskov, Louise Lang; Lyngbaek, Mark Preben; Soederlund, Line; Legaard, Grit Elster; Ehses, Jan Adam; Heywood, Sarah Elizabeth; Albrechtsen, Nicolai Jacob Wewer; Holst, Jens Juul; Karstoft, Kristian; Pedersen, Bente Klarlund; Ellingsgaard, Helga.

In: Cell Metabolism, Vol. 27, No. 6, 2018, p. 1201-1211.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Lehrskov, LL, Lyngbaek, MP, Soederlund, L, Legaard, GE, Ehses, JA, Heywood, SE, Albrechtsen, NJW, Holst, JJ, Karstoft, K, Pedersen, BK & Ellingsgaard, H 2018, 'Interleukin-6 Delays Gastric Emptying in Humans with Direct Effects on Glycemic Control', Cell Metabolism, vol. 27, no. 6, pp. 1201-1211. https://doi.org/10.1016/j.cmet.2018.04.008

APA

Lehrskov, L. L., Lyngbaek, M. P., Soederlund, L., Legaard, G. E., Ehses, J. A., Heywood, S. E., Albrechtsen, N. J. W., Holst, J. J., Karstoft, K., Pedersen, B. K., & Ellingsgaard, H. (2018). Interleukin-6 Delays Gastric Emptying in Humans with Direct Effects on Glycemic Control. Cell Metabolism, 27(6), 1201-1211. https://doi.org/10.1016/j.cmet.2018.04.008

Vancouver

Lehrskov LL, Lyngbaek MP, Soederlund L, Legaard GE, Ehses JA, Heywood SE et al. Interleukin-6 Delays Gastric Emptying in Humans with Direct Effects on Glycemic Control. Cell Metabolism. 2018;27(6):1201-1211. https://doi.org/10.1016/j.cmet.2018.04.008

Author

Lehrskov, Louise Lang ; Lyngbaek, Mark Preben ; Soederlund, Line ; Legaard, Grit Elster ; Ehses, Jan Adam ; Heywood, Sarah Elizabeth ; Albrechtsen, Nicolai Jacob Wewer ; Holst, Jens Juul ; Karstoft, Kristian ; Pedersen, Bente Klarlund ; Ellingsgaard, Helga. / Interleukin-6 Delays Gastric Emptying in Humans with Direct Effects on Glycemic Control. In: Cell Metabolism. 2018 ; Vol. 27, No. 6. pp. 1201-1211.

Bibtex

@article{303646ea99da404ca430ee2b7b3ff139,
title = "Interleukin-6 Delays Gastric Emptying in Humans with Direct Effects on Glycemic Control",
abstract = "Gastric emptying is a critical regulator of postprandial glucose and delayed gastric emptying is an important mechanism of improved glycemic control achieved by short-acting glucagon-like peptide-1 (GLP-1) analogs in clinical practice. Here we report on a novel regulatory mechanism of gastric emptying in humans. We show that increasing interleukin (IL)-6 concentrations delays gastric emptying leading to reduced postprandial glycemia. IL-6 furthermore reduces insulin secretion in a GLP-1-dependent manner while effects on gastric emptying are GLP-1 independent. Inhibitory effects of IL-6 on gastric emptying were confirmed following exercise-induced increases in IL-6. Importantly, gastric- and insulin-reducing effects were maintained in individuals with type 2 diabetes. These data have clinical implications with respect to the use of IL-6 inhibition in autoimmune/inflammatory disease, and identify a novel target that could be exploited pharmacologically to delay gastric emptying and spare insulin, which may be beneficial for the beta cell in type 2 diabetes.",
author = "Lehrskov, {Louise Lang} and Lyngbaek, {Mark Preben} and Line Soederlund and Legaard, {Grit Elster} and Ehses, {Jan Adam} and Heywood, {Sarah Elizabeth} and Albrechtsen, {Nicolai Jacob Wewer} and Holst, {Jens Juul} and Kristian Karstoft and Pedersen, {Bente Klarlund} and Helga Ellingsgaard",
year = "2018",
doi = "10.1016/j.cmet.2018.04.008",
language = "English",
volume = "27",
pages = "1201--1211",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "6",

}

RIS

TY - JOUR

T1 - Interleukin-6 Delays Gastric Emptying in Humans with Direct Effects on Glycemic Control

AU - Lehrskov, Louise Lang

AU - Lyngbaek, Mark Preben

AU - Soederlund, Line

AU - Legaard, Grit Elster

AU - Ehses, Jan Adam

AU - Heywood, Sarah Elizabeth

AU - Albrechtsen, Nicolai Jacob Wewer

AU - Holst, Jens Juul

AU - Karstoft, Kristian

AU - Pedersen, Bente Klarlund

AU - Ellingsgaard, Helga

PY - 2018

Y1 - 2018

N2 - Gastric emptying is a critical regulator of postprandial glucose and delayed gastric emptying is an important mechanism of improved glycemic control achieved by short-acting glucagon-like peptide-1 (GLP-1) analogs in clinical practice. Here we report on a novel regulatory mechanism of gastric emptying in humans. We show that increasing interleukin (IL)-6 concentrations delays gastric emptying leading to reduced postprandial glycemia. IL-6 furthermore reduces insulin secretion in a GLP-1-dependent manner while effects on gastric emptying are GLP-1 independent. Inhibitory effects of IL-6 on gastric emptying were confirmed following exercise-induced increases in IL-6. Importantly, gastric- and insulin-reducing effects were maintained in individuals with type 2 diabetes. These data have clinical implications with respect to the use of IL-6 inhibition in autoimmune/inflammatory disease, and identify a novel target that could be exploited pharmacologically to delay gastric emptying and spare insulin, which may be beneficial for the beta cell in type 2 diabetes.

AB - Gastric emptying is a critical regulator of postprandial glucose and delayed gastric emptying is an important mechanism of improved glycemic control achieved by short-acting glucagon-like peptide-1 (GLP-1) analogs in clinical practice. Here we report on a novel regulatory mechanism of gastric emptying in humans. We show that increasing interleukin (IL)-6 concentrations delays gastric emptying leading to reduced postprandial glycemia. IL-6 furthermore reduces insulin secretion in a GLP-1-dependent manner while effects on gastric emptying are GLP-1 independent. Inhibitory effects of IL-6 on gastric emptying were confirmed following exercise-induced increases in IL-6. Importantly, gastric- and insulin-reducing effects were maintained in individuals with type 2 diabetes. These data have clinical implications with respect to the use of IL-6 inhibition in autoimmune/inflammatory disease, and identify a novel target that could be exploited pharmacologically to delay gastric emptying and spare insulin, which may be beneficial for the beta cell in type 2 diabetes.

U2 - 10.1016/j.cmet.2018.04.008

DO - 10.1016/j.cmet.2018.04.008

M3 - Journal article

C2 - 29731416

VL - 27

SP - 1201

EP - 1211

JO - Cell Metabolism

JF - Cell Metabolism

SN - 1550-4131

IS - 6

ER -

ID: 213286297