Integrative analysis for finding genes and networks involved in diabetes and other complex diseases

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Integrative analysis for finding genes and networks involved in diabetes and other complex diseases. / Bergholdt, Regine; Størling, Zenia M; Lage, Kasper; Karlberg, E Olof; Olason, Páll I; Aalund, Mogens; Nerup, Jørn; Brunak, Søren; Workman, Christopher; Pociot, Flemming.

In: Genome Biology (Online Edition), Vol. 8, No. 11, 2007, p. R253.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bergholdt, R, Størling, ZM, Lage, K, Karlberg, EO, Olason, PI, Aalund, M, Nerup, J, Brunak, S, Workman, C & Pociot, F 2007, 'Integrative analysis for finding genes and networks involved in diabetes and other complex diseases', Genome Biology (Online Edition), vol. 8, no. 11, pp. R253. https://doi.org/10.1186/gb-2007-8-11-r253

APA

Bergholdt, R., Størling, Z. M., Lage, K., Karlberg, E. O., Olason, P. I., Aalund, M., Nerup, J., Brunak, S., Workman, C., & Pociot, F. (2007). Integrative analysis for finding genes and networks involved in diabetes and other complex diseases. Genome Biology (Online Edition), 8(11), R253. https://doi.org/10.1186/gb-2007-8-11-r253

Vancouver

Bergholdt R, Størling ZM, Lage K, Karlberg EO, Olason PI, Aalund M et al. Integrative analysis for finding genes and networks involved in diabetes and other complex diseases. Genome Biology (Online Edition). 2007;8(11):R253. https://doi.org/10.1186/gb-2007-8-11-r253

Author

Bergholdt, Regine ; Størling, Zenia M ; Lage, Kasper ; Karlberg, E Olof ; Olason, Páll I ; Aalund, Mogens ; Nerup, Jørn ; Brunak, Søren ; Workman, Christopher ; Pociot, Flemming. / Integrative analysis for finding genes and networks involved in diabetes and other complex diseases. In: Genome Biology (Online Edition). 2007 ; Vol. 8, No. 11. pp. R253.

Bibtex

@article{53964ff35a5f4c3fa260b614bf7af00f,
title = "Integrative analysis for finding genes and networks involved in diabetes and other complex diseases",
abstract = "We have developed an integrative analysis method combining genetic interactions, identified using type 1 diabetes genome scan data, and a high-confidence human protein interaction network. Resulting networks were ranked by the significance of the enrichment of proteins from interacting regions. We identified a number of new protein network modules and novel candidate genes/proteins for type 1 diabetes. We propose this type of integrative analysis as a general method for the elucidation of genes and networks involved in diabetes and other complex diseases.",
keywords = "Diabetes Mellitus, Type 1, Epistasis, Genetic, Genetic Markers, HLA Antigens, Humans, Protein Binding, Proteins",
author = "Regine Bergholdt and St{\o}rling, {Zenia M} and Kasper Lage and Karlberg, {E Olof} and Olason, {P{\'a}ll I} and Mogens Aalund and J{\o}rn Nerup and S{\o}ren Brunak and Christopher Workman and Flemming Pociot",
year = "2007",
doi = "10.1186/gb-2007-8-11-r253",
language = "English",
volume = "8",
pages = "R253",
journal = "Genome Biology (Online Edition)",
issn = "1474-7596",
publisher = "BioMed Central Ltd.",
number = "11",

}

RIS

TY - JOUR

T1 - Integrative analysis for finding genes and networks involved in diabetes and other complex diseases

AU - Bergholdt, Regine

AU - Størling, Zenia M

AU - Lage, Kasper

AU - Karlberg, E Olof

AU - Olason, Páll I

AU - Aalund, Mogens

AU - Nerup, Jørn

AU - Brunak, Søren

AU - Workman, Christopher

AU - Pociot, Flemming

PY - 2007

Y1 - 2007

N2 - We have developed an integrative analysis method combining genetic interactions, identified using type 1 diabetes genome scan data, and a high-confidence human protein interaction network. Resulting networks were ranked by the significance of the enrichment of proteins from interacting regions. We identified a number of new protein network modules and novel candidate genes/proteins for type 1 diabetes. We propose this type of integrative analysis as a general method for the elucidation of genes and networks involved in diabetes and other complex diseases.

AB - We have developed an integrative analysis method combining genetic interactions, identified using type 1 diabetes genome scan data, and a high-confidence human protein interaction network. Resulting networks were ranked by the significance of the enrichment of proteins from interacting regions. We identified a number of new protein network modules and novel candidate genes/proteins for type 1 diabetes. We propose this type of integrative analysis as a general method for the elucidation of genes and networks involved in diabetes and other complex diseases.

KW - Diabetes Mellitus, Type 1

KW - Epistasis, Genetic

KW - Genetic Markers

KW - HLA Antigens

KW - Humans

KW - Protein Binding

KW - Proteins

U2 - 10.1186/gb-2007-8-11-r253

DO - 10.1186/gb-2007-8-11-r253

M3 - Journal article

C2 - 18045462

VL - 8

SP - R253

JO - Genome Biology (Online Edition)

JF - Genome Biology (Online Edition)

SN - 1474-7596

IS - 11

ER -

ID: 40804652