Individuals with type 2 diabetes have higher density of small intestinal neurotensin-expressing cells

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Individuals with type 2 diabetes have higher density of small intestinal neurotensin-expressing cells. / Ferreira, Filipa P.; Pereira, Sofia S.; Costa, Madalena M.; Guimarães, Marta; Albrechtsen, Nicolai J. Wewer; Holst, Jens J.; Nora, Mário; Monteiro, Mariana P.

In: Molecular and Cellular Biochemistry, Vol. 478, No. 12, 2023, p. 2779-2787.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Ferreira, FP, Pereira, SS, Costa, MM, Guimarães, M, Albrechtsen, NJW, Holst, JJ, Nora, M & Monteiro, MP 2023, 'Individuals with type 2 diabetes have higher density of small intestinal neurotensin-expressing cells', Molecular and Cellular Biochemistry, vol. 478, no. 12, pp. 2779-2787. https://doi.org/10.1007/s11010-023-04698-z

APA

Ferreira, F. P., Pereira, S. S., Costa, M. M., Guimarães, M., Albrechtsen, N. J. W., Holst, J. J., Nora, M., & Monteiro, M. P. (2023). Individuals with type 2 diabetes have higher density of small intestinal neurotensin-expressing cells. Molecular and Cellular Biochemistry, 478(12), 2779-2787. https://doi.org/10.1007/s11010-023-04698-z

Vancouver

Ferreira FP, Pereira SS, Costa MM, Guimarães M, Albrechtsen NJW, Holst JJ et al. Individuals with type 2 diabetes have higher density of small intestinal neurotensin-expressing cells. Molecular and Cellular Biochemistry. 2023;478(12):2779-2787. https://doi.org/10.1007/s11010-023-04698-z

Author

Ferreira, Filipa P. ; Pereira, Sofia S. ; Costa, Madalena M. ; Guimarães, Marta ; Albrechtsen, Nicolai J. Wewer ; Holst, Jens J. ; Nora, Mário ; Monteiro, Mariana P. / Individuals with type 2 diabetes have higher density of small intestinal neurotensin-expressing cells. In: Molecular and Cellular Biochemistry. 2023 ; Vol. 478, No. 12. pp. 2779-2787.

Bibtex

@article{1cb63bba424e43809bfd73158d20bdc3,
title = "Individuals with type 2 diabetes have higher density of small intestinal neurotensin-expressing cells",
abstract = "Neurotensin (NT) is a gastro-intestinal hormone involved in several pathways that regulate energy and glucose homeostasis. NT was hypothesized to act in synergy with incretin hormones to potentiate its anti-diabetic effects. Additionally, circulating NT levels were shown to rise after bariatric surgery-induced weight loss. Knowledge of NT-secreting cells distribution along the small intestine and its variation according to diabetes status could provide insights on NT role in mediating type 2 diabetes (T2D) improvement after bariatric surgery. So, our aims were to characterize NT-expressing cell distribution along the human small intestine and to compare the relative density of NT-expressing cells in the small intestine of individuals with and without T2D undergoing bariatric surgery for obesity treatment. Autopsy-derived small intestine fragments (n = 30) were obtained at every 20 cm along the entire intestinal length. Additionally, jejunum biopsies (n = 29) were obtained during elective gastric bypass interventions from patients with (n = 10) or without T2D (n = 18). NT-expressing cells were identified by immunohistochemistry and quantified via computerized morphometric analysis. NT-expressing cell density increased along the human small intestine. NT-expressing cell density was significantly higher from 200 cm distal to the duodenojejunal flexure onward, as well as in subjects with T2D when compared to those without T2D. NT-expressing cell density increases along the human small gut, and a higher density is found in individuals with T2D. This finding suggests a potential role for NT in the mechanisms of disease and T2D improvement observed after bariatric surgery.",
keywords = "Bariatric surgery, Enteroendocrine cells, Neurotensin, Obesity, Small intestine, Type 2 diabetes",
author = "Ferreira, {Filipa P.} and Pereira, {Sofia S.} and Costa, {Madalena M.} and Marta Guimar{\~a}es and Albrechtsen, {Nicolai J. Wewer} and Holst, {Jens J.} and M{\'a}rio Nora and Monteiro, {Mariana P.}",
note = "Publisher Copyright: {\textcopyright} 2023, The Author(s).",
year = "2023",
doi = "10.1007/s11010-023-04698-z",
language = "English",
volume = "478",
pages = "2779--2787",
journal = "Molecular and Cellular Biochemistry",
issn = "0300-8177",
publisher = "Springer",
number = "12",

}

RIS

TY - JOUR

T1 - Individuals with type 2 diabetes have higher density of small intestinal neurotensin-expressing cells

AU - Ferreira, Filipa P.

AU - Pereira, Sofia S.

AU - Costa, Madalena M.

AU - Guimarães, Marta

AU - Albrechtsen, Nicolai J. Wewer

AU - Holst, Jens J.

AU - Nora, Mário

AU - Monteiro, Mariana P.

N1 - Publisher Copyright: © 2023, The Author(s).

PY - 2023

Y1 - 2023

N2 - Neurotensin (NT) is a gastro-intestinal hormone involved in several pathways that regulate energy and glucose homeostasis. NT was hypothesized to act in synergy with incretin hormones to potentiate its anti-diabetic effects. Additionally, circulating NT levels were shown to rise after bariatric surgery-induced weight loss. Knowledge of NT-secreting cells distribution along the small intestine and its variation according to diabetes status could provide insights on NT role in mediating type 2 diabetes (T2D) improvement after bariatric surgery. So, our aims were to characterize NT-expressing cell distribution along the human small intestine and to compare the relative density of NT-expressing cells in the small intestine of individuals with and without T2D undergoing bariatric surgery for obesity treatment. Autopsy-derived small intestine fragments (n = 30) were obtained at every 20 cm along the entire intestinal length. Additionally, jejunum biopsies (n = 29) were obtained during elective gastric bypass interventions from patients with (n = 10) or without T2D (n = 18). NT-expressing cells were identified by immunohistochemistry and quantified via computerized morphometric analysis. NT-expressing cell density increased along the human small intestine. NT-expressing cell density was significantly higher from 200 cm distal to the duodenojejunal flexure onward, as well as in subjects with T2D when compared to those without T2D. NT-expressing cell density increases along the human small gut, and a higher density is found in individuals with T2D. This finding suggests a potential role for NT in the mechanisms of disease and T2D improvement observed after bariatric surgery.

AB - Neurotensin (NT) is a gastro-intestinal hormone involved in several pathways that regulate energy and glucose homeostasis. NT was hypothesized to act in synergy with incretin hormones to potentiate its anti-diabetic effects. Additionally, circulating NT levels were shown to rise after bariatric surgery-induced weight loss. Knowledge of NT-secreting cells distribution along the small intestine and its variation according to diabetes status could provide insights on NT role in mediating type 2 diabetes (T2D) improvement after bariatric surgery. So, our aims were to characterize NT-expressing cell distribution along the human small intestine and to compare the relative density of NT-expressing cells in the small intestine of individuals with and without T2D undergoing bariatric surgery for obesity treatment. Autopsy-derived small intestine fragments (n = 30) were obtained at every 20 cm along the entire intestinal length. Additionally, jejunum biopsies (n = 29) were obtained during elective gastric bypass interventions from patients with (n = 10) or without T2D (n = 18). NT-expressing cells were identified by immunohistochemistry and quantified via computerized morphometric analysis. NT-expressing cell density increased along the human small intestine. NT-expressing cell density was significantly higher from 200 cm distal to the duodenojejunal flexure onward, as well as in subjects with T2D when compared to those without T2D. NT-expressing cell density increases along the human small gut, and a higher density is found in individuals with T2D. This finding suggests a potential role for NT in the mechanisms of disease and T2D improvement observed after bariatric surgery.

KW - Bariatric surgery

KW - Enteroendocrine cells

KW - Neurotensin

KW - Obesity

KW - Small intestine

KW - Type 2 diabetes

U2 - 10.1007/s11010-023-04698-z

DO - 10.1007/s11010-023-04698-z

M3 - Journal article

C2 - 36920577

AN - SCOPUS:85149992251

VL - 478

SP - 2779

EP - 2787

JO - Molecular and Cellular Biochemistry

JF - Molecular and Cellular Biochemistry

SN - 0300-8177

IS - 12

ER -

ID: 339993726