In-Depth Proteomic Map of Innate Lymphoid Cells from Healthy Human Skin and Blood

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

In-Depth Proteomic Map of Innate Lymphoid Cells from Healthy Human Skin and Blood. / Teunissen, Marcel B.M.; Pilgaard Møller, Line B.; Løvendorf, Marianne B.; Skov, Lone; Bonefeld, Charlotte M.; Bekkenk, Marcel W.; Clark, Rachael A.; Mann, Matthias; Dyring-Andersen, Beatrice.

In: Journal of Investigative Dermatology, Vol. 144, No. 2, 2024.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Teunissen, MBM, Pilgaard Møller, LB, Løvendorf, MB, Skov, L, Bonefeld, CM, Bekkenk, MW, Clark, RA, Mann, M & Dyring-Andersen, B 2024, 'In-Depth Proteomic Map of Innate Lymphoid Cells from Healthy Human Skin and Blood', Journal of Investigative Dermatology, vol. 144, no. 2. https://doi.org/10.1016/j.jid.2023.07.011

APA

Teunissen, M. B. M., Pilgaard Møller, L. B., Løvendorf, M. B., Skov, L., Bonefeld, C. M., Bekkenk, M. W., Clark, R. A., Mann, M., & Dyring-Andersen, B. (2024). In-Depth Proteomic Map of Innate Lymphoid Cells from Healthy Human Skin and Blood. Journal of Investigative Dermatology, 144(2). https://doi.org/10.1016/j.jid.2023.07.011

Vancouver

Teunissen MBM, Pilgaard Møller LB, Løvendorf MB, Skov L, Bonefeld CM, Bekkenk MW et al. In-Depth Proteomic Map of Innate Lymphoid Cells from Healthy Human Skin and Blood. Journal of Investigative Dermatology. 2024;144(2). https://doi.org/10.1016/j.jid.2023.07.011

Author

Teunissen, Marcel B.M. ; Pilgaard Møller, Line B. ; Løvendorf, Marianne B. ; Skov, Lone ; Bonefeld, Charlotte M. ; Bekkenk, Marcel W. ; Clark, Rachael A. ; Mann, Matthias ; Dyring-Andersen, Beatrice. / In-Depth Proteomic Map of Innate Lymphoid Cells from Healthy Human Skin and Blood. In: Journal of Investigative Dermatology. 2024 ; Vol. 144, No. 2.

Bibtex

@article{ff0e34bc810943b7b414943351ce8518,
title = "In-Depth Proteomic Map of Innate Lymphoid Cells from Healthy Human Skin and Blood",
abstract = "Innate lymphoid cells (ILCs) are essential players in the skin-associated immune system, nevertheless little is known about their proteomes and proteomic diversity. In this study, we describe about 6,600 proteins constitutively expressed by ILC2s and ILC3s from healthy human skin and blood using state-of-the-art proteomics. Although the vast majority of proteins was expressed by both ILC subsets and in both compartments, the skin ILC2s and ILC3s were more distinct than their counterparts in blood. Only skin ILC3s expressed uniquely detected proteins. Our in-depth proteomic dataset allowed us to define the cluster of differentiation marker profiles of the ILC subsets, explore distribution and abundance of proteins known to have immunological functions, as well as identify subset-specific proteins that have not previously been implicated in ILC biology. Taken together, our analyses substantially expand understanding of the protein expression signatures of ILC subsets. Going forward, these proteomic datasets will serve as valuable resources for future studies of ILC biology.",
author = "Teunissen, {Marcel B.M.} and {Pilgaard M{\o}ller}, {Line B.} and L{\o}vendorf, {Marianne B.} and Lone Skov and Bonefeld, {Charlotte M.} and Bekkenk, {Marcel W.} and Clark, {Rachael A.} and Matthias Mann and Beatrice Dyring-Andersen",
note = "Publisher Copyright: {\textcopyright} 2023 The Authors",
year = "2024",
doi = "10.1016/j.jid.2023.07.011",
language = "English",
volume = "144",
journal = "Journal of Investigative Dermatology",
issn = "0022-202X",
publisher = "nature publishing group",
number = "2",

}

RIS

TY - JOUR

T1 - In-Depth Proteomic Map of Innate Lymphoid Cells from Healthy Human Skin and Blood

AU - Teunissen, Marcel B.M.

AU - Pilgaard Møller, Line B.

AU - Løvendorf, Marianne B.

AU - Skov, Lone

AU - Bonefeld, Charlotte M.

AU - Bekkenk, Marcel W.

AU - Clark, Rachael A.

AU - Mann, Matthias

AU - Dyring-Andersen, Beatrice

N1 - Publisher Copyright: © 2023 The Authors

PY - 2024

Y1 - 2024

N2 - Innate lymphoid cells (ILCs) are essential players in the skin-associated immune system, nevertheless little is known about their proteomes and proteomic diversity. In this study, we describe about 6,600 proteins constitutively expressed by ILC2s and ILC3s from healthy human skin and blood using state-of-the-art proteomics. Although the vast majority of proteins was expressed by both ILC subsets and in both compartments, the skin ILC2s and ILC3s were more distinct than their counterparts in blood. Only skin ILC3s expressed uniquely detected proteins. Our in-depth proteomic dataset allowed us to define the cluster of differentiation marker profiles of the ILC subsets, explore distribution and abundance of proteins known to have immunological functions, as well as identify subset-specific proteins that have not previously been implicated in ILC biology. Taken together, our analyses substantially expand understanding of the protein expression signatures of ILC subsets. Going forward, these proteomic datasets will serve as valuable resources for future studies of ILC biology.

AB - Innate lymphoid cells (ILCs) are essential players in the skin-associated immune system, nevertheless little is known about their proteomes and proteomic diversity. In this study, we describe about 6,600 proteins constitutively expressed by ILC2s and ILC3s from healthy human skin and blood using state-of-the-art proteomics. Although the vast majority of proteins was expressed by both ILC subsets and in both compartments, the skin ILC2s and ILC3s were more distinct than their counterparts in blood. Only skin ILC3s expressed uniquely detected proteins. Our in-depth proteomic dataset allowed us to define the cluster of differentiation marker profiles of the ILC subsets, explore distribution and abundance of proteins known to have immunological functions, as well as identify subset-specific proteins that have not previously been implicated in ILC biology. Taken together, our analyses substantially expand understanding of the protein expression signatures of ILC subsets. Going forward, these proteomic datasets will serve as valuable resources for future studies of ILC biology.

U2 - 10.1016/j.jid.2023.07.011

DO - 10.1016/j.jid.2023.07.011

M3 - Journal article

C2 - 37544588

AN - SCOPUS:85175200101

VL - 144

JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

SN - 0022-202X

IS - 2

ER -

ID: 373886973