In Silico Systems Pharmacology to Assess Drug's Therapeutic and Toxic Effects
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In Silico Systems Pharmacology to Assess Drug's Therapeutic and Toxic Effects. / Orozco, Alejandro Aguayo; Audouze, Karine; Brunak, Soren; Taboureau, Olivier.
In: Current Pharmaceutical Design, Vol. 22, No. 46, 2016, p. 6895-6902.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - In Silico Systems Pharmacology to Assess Drug's Therapeutic and Toxic Effects
AU - Orozco, Alejandro Aguayo
AU - Audouze, Karine
AU - Brunak, Soren
AU - Taboureau, Olivier
N1 - Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
PY - 2016
Y1 - 2016
N2 - For many years, the "one target, one drug" paradigm has been the driving force behind developments in pharmaceutical research. With the recent advances in molecular biology and genomics technologies, the focus is shifting toward "drug-holistic" systems based approaches (i.e. systems pharmacology). The integration of large and diverse amount of data from chemistry and biology coupled with the development and the application of network-based approaches to cope with these data is the next paradigm of drug discovery. Systems pharmacology offers a novel way of approaching drug discovery by developing models that consider the global physiological environment of protein targets and their modification by drugs. Studying drug action across multiple scales of complexity from molecular and cellular to tissue and organism levels may help identify new druggable disease genes and to design new drugs with a better efficacy and clinical safety.
AB - For many years, the "one target, one drug" paradigm has been the driving force behind developments in pharmaceutical research. With the recent advances in molecular biology and genomics technologies, the focus is shifting toward "drug-holistic" systems based approaches (i.e. systems pharmacology). The integration of large and diverse amount of data from chemistry and biology coupled with the development and the application of network-based approaches to cope with these data is the next paradigm of drug discovery. Systems pharmacology offers a novel way of approaching drug discovery by developing models that consider the global physiological environment of protein targets and their modification by drugs. Studying drug action across multiple scales of complexity from molecular and cellular to tissue and organism levels may help identify new druggable disease genes and to design new drugs with a better efficacy and clinical safety.
KW - Journal Article
U2 - 10.2174/1381612822666160907093215
DO - 10.2174/1381612822666160907093215
M3 - Journal article
C2 - 27604605
VL - 22
SP - 6895
EP - 6902
JO - Current Pharmaceutical Design
JF - Current Pharmaceutical Design
SN - 1381-6128
IS - 46
ER -
ID: 177048562