Impact of SARS-CoV-2 antibodies at delivery in women, partners and newborns
Research output: Working paper › Preprint › Research
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Impact of SARS-CoV-2 antibodies at delivery in women, partners and newborns. / Egerup, P.; Olsen, L.F.; Christiansen, A.-M.H.; Westergaard, D.; Severinsen, E.R.; Hviid, K.V.R.; Kolte, A.M.; Boje, A.D.; Bertelsen, M.-L.M.F.; Prætorius, L.; Zedeler, A.; Nielsen, J.R.; Bang, D.; Berntsen, S.; Ethelberg-Findsen, J.; Storm, D.M.; Bello-Rodríguez, J.; Ingham, A.; Ollé-López, J.; Hoffmann, E.R.; Wilken-Jensen, C.; Krebs, L.; Jørgensen, F.S.; Westh, H.; Jørgensen, H.L.; la Cour Freiesleben, N.; Nielsen, H.S.
medRxiv, 2020. p. 1-20.Research output: Working paper › Preprint › Research
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T1 - Impact of SARS-CoV-2 antibodies at delivery in women, partners and newborns
AU - Egerup, P.
AU - Olsen, L.F.
AU - Christiansen, A.-M.H.
AU - Westergaard, D.
AU - Severinsen, E.R.
AU - Hviid, K.V.R.
AU - Kolte, A.M.
AU - Boje, A.D.
AU - Bertelsen, M.-L.M.F.
AU - Prætorius, L.
AU - Zedeler, A.
AU - Nielsen, J.R.
AU - Bang, D.
AU - Berntsen, S.
AU - Ethelberg-Findsen, J.
AU - Storm, D.M.
AU - Bello-Rodríguez, J.
AU - Ingham, A.
AU - Ollé-López, J.
AU - Hoffmann, E.R.
AU - Wilken-Jensen, C.
AU - Krebs, L.
AU - Jørgensen, F.S.
AU - Westh, H.
AU - Jørgensen, H.L.
AU - la Cour Freiesleben, N.
AU - Nielsen, H.S.
PY - 2020
Y1 - 2020
N2 - ackground Only few studies have focused on serological testing for SARS-CoV-2 in pregnant women and no previous study has investigated the frequency in partners. The aim was to investigate the frequency and impact of SARS-CoV-2 in parturient women, their partners and newborns.Methods From April 4th to July 3rd, 2020, all parturient women, their partners and newborns were invited to participate in the study. Participating women and partners had a pharyngeal swab and a blood sample taken at admission and immediately after delivery a blood sample was drawn from the umbilical cord. The swabs were analyzed for SARS-CoV-2 RNA by PCR and the blood samples were analyzed for SARS-CoV-2 antibodies. Full medical history, obstetric- and neonatal information were available.Results A total of 1,361 parturient women, 1,236 partners and 1,342 newborns participated in the study. No associations between previous COVID-19 disease and obstetric- or neonatal complications were found. The adjusted serological prevalence was 2.9% in women and 3.8% in partners. The frequency of blood type A was significantly higher in women with antibodies compared to women without antibodies. 17 newborns had SARS-CoV-2 IgG antibodies, and none had IgM antibodies. Full serological data from 1,052 families showed an absolute risk of infection of 0.37 if the partner had antibodies. Only 55% of individuals with antibodies reported symptoms.Conclusion This large prospective cohort study reports no association between COVID-19 and obstetric- or neonatal complications. The family pattern showed a substantial increase in absolute risk for women living with a partner with antibodies.
AB - ackground Only few studies have focused on serological testing for SARS-CoV-2 in pregnant women and no previous study has investigated the frequency in partners. The aim was to investigate the frequency and impact of SARS-CoV-2 in parturient women, their partners and newborns.Methods From April 4th to July 3rd, 2020, all parturient women, their partners and newborns were invited to participate in the study. Participating women and partners had a pharyngeal swab and a blood sample taken at admission and immediately after delivery a blood sample was drawn from the umbilical cord. The swabs were analyzed for SARS-CoV-2 RNA by PCR and the blood samples were analyzed for SARS-CoV-2 antibodies. Full medical history, obstetric- and neonatal information were available.Results A total of 1,361 parturient women, 1,236 partners and 1,342 newborns participated in the study. No associations between previous COVID-19 disease and obstetric- or neonatal complications were found. The adjusted serological prevalence was 2.9% in women and 3.8% in partners. The frequency of blood type A was significantly higher in women with antibodies compared to women without antibodies. 17 newborns had SARS-CoV-2 IgG antibodies, and none had IgM antibodies. Full serological data from 1,052 families showed an absolute risk of infection of 0.37 if the partner had antibodies. Only 55% of individuals with antibodies reported symptoms.Conclusion This large prospective cohort study reports no association between COVID-19 and obstetric- or neonatal complications. The family pattern showed a substantial increase in absolute risk for women living with a partner with antibodies.
U2 - 10.1101/2020.09.14.20191106
DO - 10.1101/2020.09.14.20191106
M3 - Preprint
SP - 1
EP - 20
BT - Impact of SARS-CoV-2 antibodies at delivery in women, partners and newborns
PB - medRxiv
ER -
ID: 359309391