Global priorities for large-scale biomarker-based prospective cohorts
Research output: Contribution to journal › Comment/debate › Research
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Global priorities for large-scale biomarker-based prospective cohorts. / Collins, Rory; Balaconis, Mary K.; Brunak, Søren; Chen, Zhengming; De Silva, Mary; Gaziano, J. Michael; Ginsburg, Geoffrey S.; Jha, Prabhat; Kuri, Pablo; Metspalu, Andres; Mulder, Nicola; Risch, Neil.
In: Cell Genomics, Vol. 2, No. 6, 100141, 2022.Research output: Contribution to journal › Comment/debate › Research
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TY - JOUR
T1 - Global priorities for large-scale biomarker-based prospective cohorts
AU - Collins, Rory
AU - Balaconis, Mary K.
AU - Brunak, Søren
AU - Chen, Zhengming
AU - De Silva, Mary
AU - Gaziano, J. Michael
AU - Ginsburg, Geoffrey S.
AU - Jha, Prabhat
AU - Kuri, Pablo
AU - Metspalu, Andres
AU - Mulder, Nicola
AU - Risch, Neil
N1 - Publisher Copyright: © 2022 The Author(s)
PY - 2022
Y1 - 2022
N2 - The focus of this paper is on strategic approaches for establishing population-based prospective cohorts that collect and store biological samples from very large numbers of participants to help identify the determinants of common health outcomes. In particular, it aims to address key issues related to investigation of genetic, as well as social, environmental, and ancestral, diversity; generation of detailed genetic and other types of assay data; collection of detailed lifestyle and environmental exposure information; follow-up and characterization of incident health outcomes; and overcoming obstacles to data sharing and access (including capacity building). It concludes that there is a need for strategic planning at an international level (rather than the current ad hoc approach) toward the development of a carefully selected set of deeply characterized large-scale prospective cohorts that are readily accessible by researchers around the world.
AB - The focus of this paper is on strategic approaches for establishing population-based prospective cohorts that collect and store biological samples from very large numbers of participants to help identify the determinants of common health outcomes. In particular, it aims to address key issues related to investigation of genetic, as well as social, environmental, and ancestral, diversity; generation of detailed genetic and other types of assay data; collection of detailed lifestyle and environmental exposure information; follow-up and characterization of incident health outcomes; and overcoming obstacles to data sharing and access (including capacity building). It concludes that there is a need for strategic planning at an international level (rather than the current ad hoc approach) toward the development of a carefully selected set of deeply characterized large-scale prospective cohorts that are readily accessible by researchers around the world.
U2 - 10.1016/j.xgen.2022.100141
DO - 10.1016/j.xgen.2022.100141
M3 - Comment/debate
C2 - 36778137
AN - SCOPUS:85149395015
VL - 2
JO - Cell Genomics
JF - Cell Genomics
SN - 2666-979x
IS - 6
M1 - 100141
ER -
ID: 343130677