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Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles. / Hautakangas, Heidi; Winsvold, Bendik S.; Ruotsalainen, Sanni E.; Bjornsdottir, Gyda; Harder, Aster V. E.; Kogelman, Lisette J. A.; Thomas, Laurent F.; Noordam, Raymond; Benner, Christian; Gormley, Padhraig; Artto, Ville; Banasik, Karina; Bjornsdottir, Anna; Boomsma, Dorret, I; Brumpton, Ben M.; Burgdorf, Kristoffer Sølvsten; Buring, Julie E.; Chalmer, Mona Ameri; de Boer, Irene; Dichgans, Martin; Erikstrup, Christian; Farkkila, Markus; Garbrielsen, Maiken Elvestad; Ghanbari, Mohsen; Hagen, Knut; Happola, Paavo; Hottenga, Jouke-Jan; Hrafnsdottir, Maria G.; Hveem, Kristian; Johnsen, Marianne Bakke; Kahonen, Mika; Kristoffersen, Espen S.; Kurth, Tobias; Lehtimaki, Terho; Lighart, Lannie; Magnusson, Sigurdur H.; Malik, Rainer; Pedersen, Ole Birger; Pelzer, Nadine; Penninx, Brenda W. J. H.; Ran, Caroline; Ridker, Paul M.; Rosendaal, Frits R.; Sigurdardottir, Gudrun R.; Skogholt, Anne Heidi; Sveinsson, Olafur A.; Thorgeirsson, Thorgeir E.; Ullum, Henrik; Vijfhuizen, Lisanne S.; Widen, Elisabeth; van Dijk, Ko Willems; Aromaa, Arpo; Belin, Andrea Carmine; Freilinger, Tobias; Ikram, M. Arfan; Jarvelin, Marjo-Riitta; Raitakari, Olli T.; Terwindt, Gisela M.; Kallela, Mikko; Wessman, Maija; Olesen, Jes; Chasman, Daniel, I; Nyholt, Dale R.; Stefansson, Hreinn; Stefansson, Kari; van den Maagdenberg, Arn M. J. M.; Hansen, Thomas Folkmann; Ripatti, Samuli; Zwart, John-Anker; Palotie, Aarno; Pirinen, Matti.
In:
Nature Genetics, Vol. 54, 2022, p. 152-160.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Hautakangas, H, Winsvold, BS, Ruotsalainen, SE, Bjornsdottir, G, Harder, AVE, Kogelman, LJA, Thomas, LF, Noordam, R, Benner, C, Gormley, P, Artto, V
, Banasik, K, Bjornsdottir, A, Boomsma, DI, Brumpton, BM
, Burgdorf, KS, Buring, JE, Chalmer, MA, de Boer, I, Dichgans, M, Erikstrup, C, Farkkila, M, Garbrielsen, ME, Ghanbari, M, Hagen, K, Happola, P, Hottenga, J-J, Hrafnsdottir, MG, Hveem, K, Johnsen, MB, Kahonen, M, Kristoffersen, ES, Kurth, T, Lehtimaki, T, Lighart, L, Magnusson, SH, Malik, R
, Pedersen, OB, Pelzer, N, Penninx, BWJH, Ran, C, Ridker, PM, Rosendaal, FR, Sigurdardottir, GR, Skogholt, AH, Sveinsson, OA, Thorgeirsson, TE, Ullum, H, Vijfhuizen, LS, Widen, E, van Dijk, KW, Aromaa, A, Belin, AC, Freilinger, T, Ikram, MA, Jarvelin, M-R, Raitakari, OT, Terwindt, GM, Kallela, M, Wessman, M
, Olesen, J, Chasman, DI, Nyholt, DR, Stefansson, H, Stefansson, K, van den Maagdenberg, AMJM
, Hansen, TF, Ripatti, S, Zwart, J-A, Palotie, A & Pirinen, M 2022, '
Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles',
Nature Genetics, vol. 54, pp. 152-160.
https://doi.org/10.1038/s41588-021-00990-0APA
Hautakangas, H., Winsvold, B. S., Ruotsalainen, S. E., Bjornsdottir, G., Harder, A. V. E., Kogelman, L. J. A., Thomas, L. F., Noordam, R., Benner, C., Gormley, P., Artto, V.
, Banasik, K., Bjornsdottir, A., Boomsma, D. I., Brumpton, B. M.
, Burgdorf, K. S., Buring, J. E., Chalmer, M. A., de Boer, I., ... Pirinen, M. (2022).
Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles.
Nature Genetics,
54, 152-160.
https://doi.org/10.1038/s41588-021-00990-0Vancouver
Hautakangas H, Winsvold BS, Ruotsalainen SE, Bjornsdottir G, Harder AVE, Kogelman LJA et al.
Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles.
Nature Genetics. 2022;54:152-160.
https://doi.org/10.1038/s41588-021-00990-0Author
Hautakangas, Heidi ; Winsvold, Bendik S. ; Ruotsalainen, Sanni E. ; Bjornsdottir, Gyda ; Harder, Aster V. E. ; Kogelman, Lisette J. A. ; Thomas, Laurent F. ; Noordam, Raymond ; Benner, Christian ; Gormley, Padhraig ; Artto, Ville ; Banasik, Karina ; Bjornsdottir, Anna ; Boomsma, Dorret, I ; Brumpton, Ben M. ; Burgdorf, Kristoffer Sølvsten ; Buring, Julie E. ; Chalmer, Mona Ameri ; de Boer, Irene ; Dichgans, Martin ; Erikstrup, Christian ; Farkkila, Markus ; Garbrielsen, Maiken Elvestad ; Ghanbari, Mohsen ; Hagen, Knut ; Happola, Paavo ; Hottenga, Jouke-Jan ; Hrafnsdottir, Maria G. ; Hveem, Kristian ; Johnsen, Marianne Bakke ; Kahonen, Mika ; Kristoffersen, Espen S. ; Kurth, Tobias ; Lehtimaki, Terho ; Lighart, Lannie ; Magnusson, Sigurdur H. ; Malik, Rainer ; Pedersen, Ole Birger ; Pelzer, Nadine ; Penninx, Brenda W. J. H. ; Ran, Caroline ; Ridker, Paul M. ; Rosendaal, Frits R. ; Sigurdardottir, Gudrun R. ; Skogholt, Anne Heidi ; Sveinsson, Olafur A. ; Thorgeirsson, Thorgeir E. ; Ullum, Henrik ; Vijfhuizen, Lisanne S. ; Widen, Elisabeth ; van Dijk, Ko Willems ; Aromaa, Arpo ; Belin, Andrea Carmine ; Freilinger, Tobias ; Ikram, M. Arfan ; Jarvelin, Marjo-Riitta ; Raitakari, Olli T. ; Terwindt, Gisela M. ; Kallela, Mikko ; Wessman, Maija ; Olesen, Jes ; Chasman, Daniel, I ; Nyholt, Dale R. ; Stefansson, Hreinn ; Stefansson, Kari ; van den Maagdenberg, Arn M. J. M. ; Hansen, Thomas Folkmann ; Ripatti, Samuli ; Zwart, John-Anker ; Palotie, Aarno ; Pirinen, Matti. / Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles. In: Nature Genetics. 2022 ; Vol. 54. pp. 152-160.
Bibtex
@article{44fdc070b0ce4d5099f63710caabc707,
title = "Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles",
abstract = "Migraine affects over a billion individuals worldwide but its genetic underpinning remains largely unknown. Here, we performed a genome-wide association study of 102,084 migraine cases and 771,257 controls and identified 123 loci, of which 86 are previously unknown. These loci provide an opportunity to evaluate shared and distinct genetic components in the two main migraine subtypes: migraine with aura and migraine without aura. Stratification of the risk loci using 29,679 cases with subtype information indicated three risk variants that seem specific for migraine with aura (in HMOX2, CACNA1A and MPPED2), two that seem specific for migraine without aura (near SPINK2 and near FECH) and nine that increase susceptibility for migraine regardless of subtype. The new risk loci include genes encoding recent migraine-specific drug targets, namely calcitonin gene-related peptide (CALCA/CALCB) and serotonin 1F receptor (HTR1F). Overall, genomic annotations among migraine-associated variants were enriched in both vascular and central nervous system tissue/cell types, supporting unequivocally that neurovascular mechanisms underlie migraine pathophysiology.",
author = "Heidi Hautakangas and Winsvold, {Bendik S.} and Ruotsalainen, {Sanni E.} and Gyda Bjornsdottir and Harder, {Aster V. E.} and Kogelman, {Lisette J. A.} and Thomas, {Laurent F.} and Raymond Noordam and Christian Benner and Padhraig Gormley and Ville Artto and Karina Banasik and Anna Bjornsdottir and Boomsma, {Dorret, I} and Brumpton, {Ben M.} and Burgdorf, {Kristoffer S{\o}lvsten} and Buring, {Julie E.} and Chalmer, {Mona Ameri} and {de Boer}, Irene and Martin Dichgans and Christian Erikstrup and Markus Farkkila and Garbrielsen, {Maiken Elvestad} and Mohsen Ghanbari and Knut Hagen and Paavo Happola and Jouke-Jan Hottenga and Hrafnsdottir, {Maria G.} and Kristian Hveem and Johnsen, {Marianne Bakke} and Mika Kahonen and Kristoffersen, {Espen S.} and Tobias Kurth and Terho Lehtimaki and Lannie Lighart and Magnusson, {Sigurdur H.} and Rainer Malik and Pedersen, {Ole Birger} and Nadine Pelzer and Penninx, {Brenda W. J. H.} and Caroline Ran and Ridker, {Paul M.} and Rosendaal, {Frits R.} and Sigurdardottir, {Gudrun R.} and Skogholt, {Anne Heidi} and Sveinsson, {Olafur A.} and Thorgeirsson, {Thorgeir E.} and Henrik Ullum and Vijfhuizen, {Lisanne S.} and Elisabeth Widen and {van Dijk}, {Ko Willems} and Arpo Aromaa and Belin, {Andrea Carmine} and Tobias Freilinger and Ikram, {M. Arfan} and Marjo-Riitta Jarvelin and Raitakari, {Olli T.} and Terwindt, {Gisela M.} and Mikko Kallela and Maija Wessman and Jes Olesen and Chasman, {Daniel, I} and Nyholt, {Dale R.} and Hreinn Stefansson and Kari Stefansson and {van den Maagdenberg}, {Arn M. J. M.} and Hansen, {Thomas Folkmann} and Samuli Ripatti and John-Anker Zwart and Aarno Palotie and Matti Pirinen",
year = "2022",
doi = "10.1038/s41588-021-00990-0",
language = "English",
volume = "54",
pages = "152--160",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
}
RIS
TY - JOUR
T1 - Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles
AU - Hautakangas, Heidi
AU - Winsvold, Bendik S.
AU - Ruotsalainen, Sanni E.
AU - Bjornsdottir, Gyda
AU - Harder, Aster V. E.
AU - Kogelman, Lisette J. A.
AU - Thomas, Laurent F.
AU - Noordam, Raymond
AU - Benner, Christian
AU - Gormley, Padhraig
AU - Artto, Ville
AU - Banasik, Karina
AU - Bjornsdottir, Anna
AU - Boomsma, Dorret, I
AU - Brumpton, Ben M.
AU - Burgdorf, Kristoffer Sølvsten
AU - Buring, Julie E.
AU - Chalmer, Mona Ameri
AU - de Boer, Irene
AU - Dichgans, Martin
AU - Erikstrup, Christian
AU - Farkkila, Markus
AU - Garbrielsen, Maiken Elvestad
AU - Ghanbari, Mohsen
AU - Hagen, Knut
AU - Happola, Paavo
AU - Hottenga, Jouke-Jan
AU - Hrafnsdottir, Maria G.
AU - Hveem, Kristian
AU - Johnsen, Marianne Bakke
AU - Kahonen, Mika
AU - Kristoffersen, Espen S.
AU - Kurth, Tobias
AU - Lehtimaki, Terho
AU - Lighart, Lannie
AU - Magnusson, Sigurdur H.
AU - Malik, Rainer
AU - Pedersen, Ole Birger
AU - Pelzer, Nadine
AU - Penninx, Brenda W. J. H.
AU - Ran, Caroline
AU - Ridker, Paul M.
AU - Rosendaal, Frits R.
AU - Sigurdardottir, Gudrun R.
AU - Skogholt, Anne Heidi
AU - Sveinsson, Olafur A.
AU - Thorgeirsson, Thorgeir E.
AU - Ullum, Henrik
AU - Vijfhuizen, Lisanne S.
AU - Widen, Elisabeth
AU - van Dijk, Ko Willems
AU - Aromaa, Arpo
AU - Belin, Andrea Carmine
AU - Freilinger, Tobias
AU - Ikram, M. Arfan
AU - Jarvelin, Marjo-Riitta
AU - Raitakari, Olli T.
AU - Terwindt, Gisela M.
AU - Kallela, Mikko
AU - Wessman, Maija
AU - Olesen, Jes
AU - Chasman, Daniel, I
AU - Nyholt, Dale R.
AU - Stefansson, Hreinn
AU - Stefansson, Kari
AU - van den Maagdenberg, Arn M. J. M.
AU - Hansen, Thomas Folkmann
AU - Ripatti, Samuli
AU - Zwart, John-Anker
AU - Palotie, Aarno
AU - Pirinen, Matti
PY - 2022
Y1 - 2022
N2 - Migraine affects over a billion individuals worldwide but its genetic underpinning remains largely unknown. Here, we performed a genome-wide association study of 102,084 migraine cases and 771,257 controls and identified 123 loci, of which 86 are previously unknown. These loci provide an opportunity to evaluate shared and distinct genetic components in the two main migraine subtypes: migraine with aura and migraine without aura. Stratification of the risk loci using 29,679 cases with subtype information indicated three risk variants that seem specific for migraine with aura (in HMOX2, CACNA1A and MPPED2), two that seem specific for migraine without aura (near SPINK2 and near FECH) and nine that increase susceptibility for migraine regardless of subtype. The new risk loci include genes encoding recent migraine-specific drug targets, namely calcitonin gene-related peptide (CALCA/CALCB) and serotonin 1F receptor (HTR1F). Overall, genomic annotations among migraine-associated variants were enriched in both vascular and central nervous system tissue/cell types, supporting unequivocally that neurovascular mechanisms underlie migraine pathophysiology.
AB - Migraine affects over a billion individuals worldwide but its genetic underpinning remains largely unknown. Here, we performed a genome-wide association study of 102,084 migraine cases and 771,257 controls and identified 123 loci, of which 86 are previously unknown. These loci provide an opportunity to evaluate shared and distinct genetic components in the two main migraine subtypes: migraine with aura and migraine without aura. Stratification of the risk loci using 29,679 cases with subtype information indicated three risk variants that seem specific for migraine with aura (in HMOX2, CACNA1A and MPPED2), two that seem specific for migraine without aura (near SPINK2 and near FECH) and nine that increase susceptibility for migraine regardless of subtype. The new risk loci include genes encoding recent migraine-specific drug targets, namely calcitonin gene-related peptide (CALCA/CALCB) and serotonin 1F receptor (HTR1F). Overall, genomic annotations among migraine-associated variants were enriched in both vascular and central nervous system tissue/cell types, supporting unequivocally that neurovascular mechanisms underlie migraine pathophysiology.
U2 - 10.1038/s41588-021-00990-0
DO - 10.1038/s41588-021-00990-0
M3 - Journal article
C2 - 35115687
VL - 54
SP - 152
EP - 160
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
ER -
