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Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease. / Bryois, Julien; Skene, Nathan G.; Hansen, Thomas Folkmann; Kogelman, Lisette J.A.; Watson, Hunna J.; Liu, Zijing; Eating Disorders Working Group of the Psychiatric Genomics Consortium; Adan, Roger; Alfredsson, Lars; Ando, Tetsuya; Andreassen, Ole; Baker, Jessica; Bergen, Andrew; Berrettini, Wade; Birgegård, Andreas; Boden, Joseph; Boehm, Ilka; Boni, Claudette; Boraska Perica, Vesna; Brandt, Harry; Breen, Gerome; Bryois, Julien; Buehren, Katharina; Bulik, Cynthia; Burghardt, Roland; Cassina, Matteo; Cichon, Sven; Clementi, Maurizio; Coleman, Jonathan; Cone, Roger; Courtet, Philippe; Crawford, Steven; Crow, Scott; Crowley, James; Danner, Unna; Davis, Oliver; de Zwaan, Martina; Dedoussis, George; Degortes, Daniela; DeSocio, Janiece; Dick, Danielle; Hinney, Anke; Grove, Jakob; Larsen, Janne; Mattheisen, Manuel; Mortensen, Preben Bo; Petersen, Liselotte; Werge, Thomas; Zeggini, Eleftheria; Zerwas, Stephanie; Zipfel, Stephan ; International Headache Genetics Consortium; Anttila, Verneri; Artto, Ville; Belin, Andrea Carmine; Christensen, Anne Francke; Esserlind, Ann-Louise; Kogelman, Lisette J.A.; Olesen, Jes; Olesen, Jes; Winsvold, Bendik S; Zhao, Huiying; Zwart, John-Anker; 23andMe Research Team.
In:
Nature Genetics, Vol. 52, 05.2020, p. 482-493.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Bryois, J, Skene, NG
, Hansen, TF, Kogelman, LJA, Watson, HJ, Liu, Z, Eating Disorders Working Group of the Psychiatric Genomics Consortium, Adan, R, Alfredsson, L, Ando, T, Andreassen, O, Baker, J, Bergen, A, Berrettini, W, Birgegård, A, Boden, J, Boehm, I, Boni, C, Boraska Perica, V, Brandt, H, Breen, G, Bryois, J, Buehren, K, Bulik, C, Burghardt, R, Cassina, M, Cichon, S, Clementi, M, Coleman, J, Cone, R, Courtet, P, Crawford, S, Crow, S, Crowley, J, Danner, U, Davis, O, de Zwaan, M, Dedoussis, G, Degortes, D, DeSocio, J, Dick, D, Hinney, A, Grove, J, Larsen, J, Mattheisen, M, Mortensen, PB, Petersen, L
, Werge, T, Zeggini, E, Zerwas, S, Zipfel, S, International Headache Genetics Consortium, Anttila, V, Artto, V, Belin, AC, Christensen, AF, Esserlind, A-L, Kogelman, LJA
, Olesen, J, Olesen, J, Winsvold, BS, Zhao, H, Zwart, J-A & 23andMe Research Team 2020, '
Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease',
Nature Genetics, vol. 52, pp. 482-493.
https://doi.org/10.1038/s41588-020-0610-9APA
Bryois, J., Skene, N. G.
, Hansen, T. F., Kogelman, L. J. A., Watson, H. J., Liu, Z., Eating Disorders Working Group of the Psychiatric Genomics Consortium, Adan, R., Alfredsson, L., Ando, T., Andreassen, O., Baker, J., Bergen, A., Berrettini, W., Birgegård, A., Boden, J., Boehm, I., Boni, C., Boraska Perica, V., ... 23andMe Research Team (2020).
Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease.
Nature Genetics,
52, 482-493.
https://doi.org/10.1038/s41588-020-0610-9Vancouver
Bryois J, Skene NG
, Hansen TF, Kogelman LJA, Watson HJ, Liu Z et al.
Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease.
Nature Genetics. 2020 May;52:482-493.
https://doi.org/10.1038/s41588-020-0610-9Author
Bryois, Julien ; Skene, Nathan G. ; Hansen, Thomas Folkmann ; Kogelman, Lisette J.A. ; Watson, Hunna J. ; Liu, Zijing ; Eating Disorders Working Group of the Psychiatric Genomics Consortium ; Adan, Roger ; Alfredsson, Lars ; Ando, Tetsuya ; Andreassen, Ole ; Baker, Jessica ; Bergen, Andrew ; Berrettini, Wade ; Birgegård, Andreas ; Boden, Joseph ; Boehm, Ilka ; Boni, Claudette ; Boraska Perica, Vesna ; Brandt, Harry ; Breen, Gerome ; Bryois, Julien ; Buehren, Katharina ; Bulik, Cynthia ; Burghardt, Roland ; Cassina, Matteo ; Cichon, Sven ; Clementi, Maurizio ; Coleman, Jonathan ; Cone, Roger ; Courtet, Philippe ; Crawford, Steven ; Crow, Scott ; Crowley, James ; Danner, Unna ; Davis, Oliver ; de Zwaan, Martina ; Dedoussis, George ; Degortes, Daniela ; DeSocio, Janiece ; Dick, Danielle ; Hinney, Anke ; Grove, Jakob ; Larsen, Janne ; Mattheisen, Manuel ; Mortensen, Preben Bo ; Petersen, Liselotte ; Werge, Thomas ; Zeggini, Eleftheria ; Zerwas, Stephanie ; Zipfel, Stephan ; International Headache Genetics Consortium ; Anttila, Verneri ; Artto, Ville ; Belin, Andrea Carmine ; Christensen, Anne Francke ; Esserlind, Ann-Louise ; Kogelman, Lisette J.A. ; Olesen, Jes ; Olesen, Jes ; Winsvold, Bendik S ; Zhao, Huiying ; Zwart, John-Anker ; 23andMe Research Team. / Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease. In: Nature Genetics. 2020 ; Vol. 52. pp. 482-493.
Bibtex
@article{597bd2f936684d19af18b41b4ac85e76,
title = "Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson{\textquoteright}s disease",
abstract = "Genome-wide association studies have discovered hundreds of loci associated with complex brain disorders, but it remains unclear in which cell types these loci are active. Here we integrate genome-wide association study results with single-cell transcriptomic data from the entire mouse nervous system to systematically identify cell types underlying brain complex traits. We show that psychiatric disorders are predominantly associated with projecting excitatory and inhibitory neurons. Neurological diseases were associated with different cell types, which is consistent with other lines of evidence. Notably, Parkinson{\textquoteright}s disease was genetically associated not only with cholinergic and monoaminergic neurons (which include dopaminergic neurons) but also with enteric neurons and oligodendrocytes. Using post-mortem brain transcriptomic data, we confirmed alterations in these cells, even at the earliest stages of disease progression. Our study provides an important framework for understanding the cellular basis of complex brain maladies, and reveals an unexpected role of oligodendrocytes in Parkinson{\textquoteright}s disease.",
author = "Julien Bryois and Skene, {Nathan G.} and Hansen, {Thomas Folkmann} and Kogelman, {Lisette J.A.} and Watson, {Hunna J.} and Zijing Liu and {Eating Disorders Working Group of the Psychiatric Genomics Consortium} and Roger Adan and Lars Alfredsson and Tetsuya Ando and Ole Andreassen and Jessica Baker and Andrew Bergen and Wade Berrettini and Andreas Birgeg{\aa}rd and Joseph Boden and Ilka Boehm and Claudette Boni and {Boraska Perica}, Vesna and Harry Brandt and Gerome Breen and Julien Bryois and Katharina Buehren and Cynthia Bulik and Roland Burghardt and Matteo Cassina and Sven Cichon and Maurizio Clementi and Jonathan Coleman and Roger Cone and Philippe Courtet and Steven Crawford and Scott Crow and James Crowley and Unna Danner and Oliver Davis and {de Zwaan}, Martina and George Dedoussis and Daniela Degortes and Janiece DeSocio and Danielle Dick and Anke Hinney and Jakob Grove and Janne Larsen and Manuel Mattheisen and Mortensen, {Preben Bo} and Liselotte Petersen and Thomas Werge and Eleftheria Zeggini and Stephanie Zerwas and Stephan Zipfel and {International Headache Genetics Consortium} and Verneri Anttila and Ville Artto and Belin, {Andrea Carmine} and Christensen, {Anne Francke} and Ann-Louise Esserlind and Kogelman, {Lisette J.A.} and Jes Olesen and Jes Olesen and Winsvold, {Bendik S} and Huiying Zhao and John-Anker Zwart and {23andMe Research Team}",
year = "2020",
month = may,
doi = "10.1038/s41588-020-0610-9",
language = "English",
volume = "52",
pages = "482--493",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
}
RIS
TY - JOUR
T1 - Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease
AU - Bryois, Julien
AU - Skene, Nathan G.
AU - Hansen, Thomas Folkmann
AU - Kogelman, Lisette J.A.
AU - Watson, Hunna J.
AU - Liu, Zijing
AU - Eating Disorders Working Group of the Psychiatric Genomics Consortium
AU - Adan, Roger
AU - Alfredsson, Lars
AU - Ando, Tetsuya
AU - Andreassen, Ole
AU - Baker, Jessica
AU - Bergen, Andrew
AU - Berrettini, Wade
AU - Birgegård, Andreas
AU - Boden, Joseph
AU - Boehm, Ilka
AU - Boni, Claudette
AU - Boraska Perica, Vesna
AU - Brandt, Harry
AU - Breen, Gerome
AU - Bryois, Julien
AU - Buehren, Katharina
AU - Bulik, Cynthia
AU - Burghardt, Roland
AU - Cassina, Matteo
AU - Cichon, Sven
AU - Clementi, Maurizio
AU - Coleman, Jonathan
AU - Cone, Roger
AU - Courtet, Philippe
AU - Crawford, Steven
AU - Crow, Scott
AU - Crowley, James
AU - Danner, Unna
AU - Davis, Oliver
AU - de Zwaan, Martina
AU - Dedoussis, George
AU - Degortes, Daniela
AU - DeSocio, Janiece
AU - Dick, Danielle
AU - Hinney, Anke
AU - Grove, Jakob
AU - Larsen, Janne
AU - Mattheisen, Manuel
AU - Mortensen, Preben Bo
AU - Petersen, Liselotte
AU - Werge, Thomas
AU - Zeggini, Eleftheria
AU - Zerwas, Stephanie
AU - Zipfel, Stephan
AU - International Headache Genetics Consortium
AU - Anttila, Verneri
AU - Artto, Ville
AU - Belin, Andrea Carmine
AU - Christensen, Anne Francke
AU - Esserlind, Ann-Louise
AU - Kogelman, Lisette J.A.
AU - Olesen, Jes
AU - Olesen, Jes
AU - Winsvold, Bendik S
AU - Zhao, Huiying
AU - Zwart, John-Anker
AU - 23andMe Research Team
PY - 2020/5
Y1 - 2020/5
N2 - Genome-wide association studies have discovered hundreds of loci associated with complex brain disorders, but it remains unclear in which cell types these loci are active. Here we integrate genome-wide association study results with single-cell transcriptomic data from the entire mouse nervous system to systematically identify cell types underlying brain complex traits. We show that psychiatric disorders are predominantly associated with projecting excitatory and inhibitory neurons. Neurological diseases were associated with different cell types, which is consistent with other lines of evidence. Notably, Parkinson’s disease was genetically associated not only with cholinergic and monoaminergic neurons (which include dopaminergic neurons) but also with enteric neurons and oligodendrocytes. Using post-mortem brain transcriptomic data, we confirmed alterations in these cells, even at the earliest stages of disease progression. Our study provides an important framework for understanding the cellular basis of complex brain maladies, and reveals an unexpected role of oligodendrocytes in Parkinson’s disease.
AB - Genome-wide association studies have discovered hundreds of loci associated with complex brain disorders, but it remains unclear in which cell types these loci are active. Here we integrate genome-wide association study results with single-cell transcriptomic data from the entire mouse nervous system to systematically identify cell types underlying brain complex traits. We show that psychiatric disorders are predominantly associated with projecting excitatory and inhibitory neurons. Neurological diseases were associated with different cell types, which is consistent with other lines of evidence. Notably, Parkinson’s disease was genetically associated not only with cholinergic and monoaminergic neurons (which include dopaminergic neurons) but also with enteric neurons and oligodendrocytes. Using post-mortem brain transcriptomic data, we confirmed alterations in these cells, even at the earliest stages of disease progression. Our study provides an important framework for understanding the cellular basis of complex brain maladies, and reveals an unexpected role of oligodendrocytes in Parkinson’s disease.
U2 - 10.1038/s41588-020-0610-9
DO - 10.1038/s41588-020-0610-9
M3 - Journal article
C2 - 32341526
AN - SCOPUS:85084195663
VL - 52
SP - 482
EP - 493
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
ER -
