FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism. / Sakaguchi, Masaji; Cai, Weikang; Wang, Chih-Hao; Cederquist, Carly T; Damasio, Marcos; Homan, Erica P; Batista, Thiago; Ramirez, Alfred K; Gupta, Manoj K; Steger, Martin; Wewer Albrechtsen, Nicolai J; Singh, Shailendra Kumar; Araki, Eiichi; Mann, Matthias; Enerbäck, Sven; Kahn, C Ronald.

In: Nature Communications, Vol. 10, No. 1, 1582, 05.04.2019.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sakaguchi, M, Cai, W, Wang, C-H, Cederquist, CT, Damasio, M, Homan, EP, Batista, T, Ramirez, AK, Gupta, MK, Steger, M, Wewer Albrechtsen, NJ, Singh, SK, Araki, E, Mann, M, Enerbäck, S & Kahn, CR 2019, 'FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism', Nature Communications, vol. 10, no. 1, 1582. https://doi.org/10.1038/s41467-019-09418-0

APA

Sakaguchi, M., Cai, W., Wang, C-H., Cederquist, C. T., Damasio, M., Homan, E. P., Batista, T., Ramirez, A. K., Gupta, M. K., Steger, M., Wewer Albrechtsen, N. J., Singh, S. K., Araki, E., Mann, M., Enerbäck, S., & Kahn, C. R. (2019). FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism. Nature Communications, 10(1), [1582]. https://doi.org/10.1038/s41467-019-09418-0

Vancouver

Sakaguchi M, Cai W, Wang C-H, Cederquist CT, Damasio M, Homan EP et al. FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism. Nature Communications. 2019 Apr 5;10(1). 1582. https://doi.org/10.1038/s41467-019-09418-0

Author

Sakaguchi, Masaji ; Cai, Weikang ; Wang, Chih-Hao ; Cederquist, Carly T ; Damasio, Marcos ; Homan, Erica P ; Batista, Thiago ; Ramirez, Alfred K ; Gupta, Manoj K ; Steger, Martin ; Wewer Albrechtsen, Nicolai J ; Singh, Shailendra Kumar ; Araki, Eiichi ; Mann, Matthias ; Enerbäck, Sven ; Kahn, C Ronald. / FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism. In: Nature Communications. 2019 ; Vol. 10, No. 1.

Bibtex

@article{20ddb44eed64428484b2addfc25deb0e,
title = "FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism",
abstract = "A major target of insulin signaling is the FoxO family of Forkhead transcription factors, which translocate from the nucleus to the cytoplasm following insulin-stimulated phosphorylation. Here we show that the Forkhead transcription factors FoxK1 and FoxK2 are also downstream targets of insulin action, but that following insulin stimulation, they translocate from the cytoplasm to nucleus, reciprocal to the translocation of FoxO1. FoxK1/FoxK2 translocation to the nucleus is dependent on the Akt-mTOR pathway, while its localization to the cytoplasm in the basal state is dependent on GSK3. Knockdown of FoxK1 and FoxK2 in liver cells results in upregulation of genes related to apoptosis and down-regulation of genes involved in cell cycle and lipid metabolism. This is associated with decreased cell proliferation and altered mitochondrial fatty acid metabolism. Thus, FoxK1/K2 are reciprocally regulated to FoxO1 following insulin stimulation and play a critical role in the control of apoptosis, metabolism and mitochondrial function.",
author = "Masaji Sakaguchi and Weikang Cai and Chih-Hao Wang and Cederquist, {Carly T} and Marcos Damasio and Homan, {Erica P} and Thiago Batista and Ramirez, {Alfred K} and Gupta, {Manoj K} and Martin Steger and {Wewer Albrechtsen}, {Nicolai J} and Singh, {Shailendra Kumar} and Eiichi Araki and Matthias Mann and Sven Enerb{\"a}ck and Kahn, {C Ronald}",
year = "2019",
month = apr,
day = "5",
doi = "10.1038/s41467-019-09418-0",
language = "English",
volume = "10",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism

AU - Sakaguchi, Masaji

AU - Cai, Weikang

AU - Wang, Chih-Hao

AU - Cederquist, Carly T

AU - Damasio, Marcos

AU - Homan, Erica P

AU - Batista, Thiago

AU - Ramirez, Alfred K

AU - Gupta, Manoj K

AU - Steger, Martin

AU - Wewer Albrechtsen, Nicolai J

AU - Singh, Shailendra Kumar

AU - Araki, Eiichi

AU - Mann, Matthias

AU - Enerbäck, Sven

AU - Kahn, C Ronald

PY - 2019/4/5

Y1 - 2019/4/5

N2 - A major target of insulin signaling is the FoxO family of Forkhead transcription factors, which translocate from the nucleus to the cytoplasm following insulin-stimulated phosphorylation. Here we show that the Forkhead transcription factors FoxK1 and FoxK2 are also downstream targets of insulin action, but that following insulin stimulation, they translocate from the cytoplasm to nucleus, reciprocal to the translocation of FoxO1. FoxK1/FoxK2 translocation to the nucleus is dependent on the Akt-mTOR pathway, while its localization to the cytoplasm in the basal state is dependent on GSK3. Knockdown of FoxK1 and FoxK2 in liver cells results in upregulation of genes related to apoptosis and down-regulation of genes involved in cell cycle and lipid metabolism. This is associated with decreased cell proliferation and altered mitochondrial fatty acid metabolism. Thus, FoxK1/K2 are reciprocally regulated to FoxO1 following insulin stimulation and play a critical role in the control of apoptosis, metabolism and mitochondrial function.

AB - A major target of insulin signaling is the FoxO family of Forkhead transcription factors, which translocate from the nucleus to the cytoplasm following insulin-stimulated phosphorylation. Here we show that the Forkhead transcription factors FoxK1 and FoxK2 are also downstream targets of insulin action, but that following insulin stimulation, they translocate from the cytoplasm to nucleus, reciprocal to the translocation of FoxO1. FoxK1/FoxK2 translocation to the nucleus is dependent on the Akt-mTOR pathway, while its localization to the cytoplasm in the basal state is dependent on GSK3. Knockdown of FoxK1 and FoxK2 in liver cells results in upregulation of genes related to apoptosis and down-regulation of genes involved in cell cycle and lipid metabolism. This is associated with decreased cell proliferation and altered mitochondrial fatty acid metabolism. Thus, FoxK1/K2 are reciprocally regulated to FoxO1 following insulin stimulation and play a critical role in the control of apoptosis, metabolism and mitochondrial function.

U2 - 10.1038/s41467-019-09418-0

DO - 10.1038/s41467-019-09418-0

M3 - Journal article

C2 - 30952843

VL - 10

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 1582

ER -

ID: 216343824