TY - JOUR

T1 - Finding Ophthalmic Risk and Evaluating the Value of Eye exams and their predictive Reliability (FOREVER)—A cohort study in a Danish high street optician setting

T2 - Design and methodology

AU - Freiberg, Josefine

AU - Rovelt, Jens

AU - Gazzard, Gus

AU - Cour, Morten la

AU - Kolko, Miriam

AU - Torp‐Pedersen, Christian

AU - Benn, Marianne

AU - Brunak, Søren

AU - Cour, Morten la

AU - Tolstrup, Janne

AU - Toft‐Petersen, Anne Pernille

AU - Burgdorf, Kristoffer Sølvsten

AU - Banasik, Karina

AU - Chmura, Piotr Jaroslaw

AU - Freiberg, Josefine

AU - Rovelt, Jens

AU - Thornit, Dorte Nellemann

AU - Foster, Paul

AU - Gazzard, Gus

AU - Crabb, David P.

AU - Viswanathan, Ananth

AU - Barman, Sarah

AU - Owen, Christopher G.

AU - Rudnicka, Alicja R.

PY - 2024

Y1 - 2024

N2 - PurposeThe purpose of the study was to describe the rationale and design of Project FOREVER (Finding Ophthalmic Risk and Evaluating the Value of Eye exams and their predictive Reliability).DesignProject FOREVER will build a comprehensive database of clinical eye and vision data collected from ~280 000 adults at 100 optician stores across Denmark. The FOREVER database (FOREVERdb) includes detailed data from refraction, visual acuity, intraocular pressure, corneal thickness, visual field assessments and retinal fundus images. Linkage to the comprehensive Danish national registries with, that is diagnostic and prescribing data permits investigation of rare associations and risk factors. 30 000 individuals over 50 also provide a saliva sample for later genetic studies and blood pressure measurements. Of these 30 000, 10 000 will also get optical coherence tomography (OCT) nerve and retinal scans. This subpopulation data is reviewed by ophthalmologists for disease detection. All participants will be asked to complete a questionnaire assessing lifestyle, self-perceived eye health and general health. Enrolment of participants began in April 2022.PerspectiveThe FOREVERdb is a powerful tool to answer a wide range of research questions that can pave the way for better eye health. This database will provide valuable insights for future studies investigating the correlations between eye and general health in a Danish population cohort, enabling research to identify potential risk factors for a range of diseases.

AB - PurposeThe purpose of the study was to describe the rationale and design of Project FOREVER (Finding Ophthalmic Risk and Evaluating the Value of Eye exams and their predictive Reliability).DesignProject FOREVER will build a comprehensive database of clinical eye and vision data collected from ~280 000 adults at 100 optician stores across Denmark. The FOREVER database (FOREVERdb) includes detailed data from refraction, visual acuity, intraocular pressure, corneal thickness, visual field assessments and retinal fundus images. Linkage to the comprehensive Danish national registries with, that is diagnostic and prescribing data permits investigation of rare associations and risk factors. 30 000 individuals over 50 also provide a saliva sample for later genetic studies and blood pressure measurements. Of these 30 000, 10 000 will also get optical coherence tomography (OCT) nerve and retinal scans. This subpopulation data is reviewed by ophthalmologists for disease detection. All participants will be asked to complete a questionnaire assessing lifestyle, self-perceived eye health and general health. Enrolment of participants began in April 2022.PerspectiveThe FOREVERdb is a powerful tool to answer a wide range of research questions that can pave the way for better eye health. This database will provide valuable insights for future studies investigating the correlations between eye and general health in a Danish population cohort, enabling research to identify potential risk factors for a range of diseases.

U2 - 10.1111/aos.15693

DO - 10.1111/aos.15693

M3 - Journal article

C2 - 37140185

VL - 102

SP - 80

EP - 90

JO - Acta Ophthalmologica

JF - Acta Ophthalmologica

SN - 1755-375X

IS - 1

ER -