Ezrin mediates c-Myc actions in prostate cancer cell invasion

Research output: Contribution to journal › Journal article › Research › peer-review

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Ezrin mediates c-Myc actions in prostate cancer cell invasion. / Chuan, Yin Choy; Iglesias Gato, Diego; Fernandez-Perez, L; Cedazo-Minguez, A; Pang, S-T; Norstedt, G; Pousette, A; Flores-Morales, Amilcar.

In: Oncogene, Vol. 29, No. 10, 2010, p. 1531-42.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Chuan, YC, Iglesias Gato, D, Fernandez-Perez, L, Cedazo-Minguez, A, Pang, S-T, Norstedt, G, Pousette, A & Flores-Morales, A 2010, 'Ezrin mediates c-Myc actions in prostate cancer cell invasion', Oncogene, vol. 29, no. 10, pp. 1531-42. https://doi.org/10.1038/onc.2009.442

APA

Chuan, Y. C., Iglesias Gato, D., Fernandez-Perez, L., Cedazo-Minguez, A., Pang, S-T., Norstedt, G., Pousette, A., & Flores-Morales, A. (2010). Ezrin mediates c-Myc actions in prostate cancer cell invasion. Oncogene, 29(10), 1531-42. https://doi.org/10.1038/onc.2009.442

Vancouver

Chuan YC, Iglesias Gato D, Fernandez-Perez L, Cedazo-Minguez A, Pang S-T, Norstedt G et al. Ezrin mediates c-Myc actions in prostate cancer cell invasion. Oncogene. 2010;29(10):1531-42. https://doi.org/10.1038/onc.2009.442

Author

Chuan, Yin Choy ; Iglesias Gato, Diego ; Fernandez-Perez, L ; Cedazo-Minguez, A ; Pang, S-T ; Norstedt, G ; Pousette, A ; Flores-Morales, Amilcar. / Ezrin mediates c-Myc actions in prostate cancer cell invasion. In: Oncogene. 2010 ; Vol. 29, No. 10. pp. 1531-42.

Bibtex

@article{cd989f903cab11df928f000ea68e967b,
title = "Ezrin mediates c-Myc actions in prostate cancer cell invasion",
abstract = "The forced overexpression of c-Myc in mouse prostate and in normal human prostate epithelial cells results in tumor transformation with an invasive phenotype. How c-Myc regulates cell invasion is poorly understood. In this study, we have investigated the interplay of c-Myc and androgens in the regulation of prostate cancer cell invasion. We found that c-Myc induces cell invasion and anchorage-independent growth by regulating ezrin protein expression in the presence of androgens. The activity of the ezrin promoter is controlled by androgens through c-Myc, which binds to a phylogenetically conserved E-Box located in the proximal promoter region. Besides, we also show that ezrin is an important regulator of c-Myc protein levels. These effects are achieved through androgen-induced changes in ezrin phosphorylation, which results in the regulation of downstream signals. These downstream signals involve the modulation of Akt and GSK-3beta activity resulting in increased c-Myc protein synthesis and inhibition of its degradation. In summary, we have shown a key role for ezrin as a mediator of c-Myc-induced tumorigenesis in prostate cancer cells.",
author = "Chuan, {Yin Choy} and {Iglesias Gato}, Diego and L Fernandez-Perez and A Cedazo-Minguez and S-T Pang and G Norstedt and A Pousette and Amilcar Flores-Morales",
year = "2010",
doi = "10.1038/onc.2009.442",
language = "English",
volume = "29",
pages = "1531--42",
journal = "Oncogene",
issn = "0950-9232",
publisher = "nature publishing group",
number = "10",

}

RIS

TY - JOUR

T1 - Ezrin mediates c-Myc actions in prostate cancer cell invasion

AU - Chuan, Yin Choy

AU - Iglesias Gato, Diego

AU - Fernandez-Perez, L

AU - Cedazo-Minguez, A

AU - Pang, S-T

AU - Norstedt, G

AU - Pousette, A

AU - Flores-Morales, Amilcar

PY - 2010

Y1 - 2010

N2 - The forced overexpression of c-Myc in mouse prostate and in normal human prostate epithelial cells results in tumor transformation with an invasive phenotype. How c-Myc regulates cell invasion is poorly understood. In this study, we have investigated the interplay of c-Myc and androgens in the regulation of prostate cancer cell invasion. We found that c-Myc induces cell invasion and anchorage-independent growth by regulating ezrin protein expression in the presence of androgens. The activity of the ezrin promoter is controlled by androgens through c-Myc, which binds to a phylogenetically conserved E-Box located in the proximal promoter region. Besides, we also show that ezrin is an important regulator of c-Myc protein levels. These effects are achieved through androgen-induced changes in ezrin phosphorylation, which results in the regulation of downstream signals. These downstream signals involve the modulation of Akt and GSK-3beta activity resulting in increased c-Myc protein synthesis and inhibition of its degradation. In summary, we have shown a key role for ezrin as a mediator of c-Myc-induced tumorigenesis in prostate cancer cells.

AB - The forced overexpression of c-Myc in mouse prostate and in normal human prostate epithelial cells results in tumor transformation with an invasive phenotype. How c-Myc regulates cell invasion is poorly understood. In this study, we have investigated the interplay of c-Myc and androgens in the regulation of prostate cancer cell invasion. We found that c-Myc induces cell invasion and anchorage-independent growth by regulating ezrin protein expression in the presence of androgens. The activity of the ezrin promoter is controlled by androgens through c-Myc, which binds to a phylogenetically conserved E-Box located in the proximal promoter region. Besides, we also show that ezrin is an important regulator of c-Myc protein levels. These effects are achieved through androgen-induced changes in ezrin phosphorylation, which results in the regulation of downstream signals. These downstream signals involve the modulation of Akt and GSK-3beta activity resulting in increased c-Myc protein synthesis and inhibition of its degradation. In summary, we have shown a key role for ezrin as a mediator of c-Myc-induced tumorigenesis in prostate cancer cells.

U2 - 10.1038/onc.2009.442

DO - 10.1038/onc.2009.442

M3 - Journal article

C2 - 20010876

VL - 29

SP - 1531

EP - 1542

JO - Oncogene

JF - Oncogene

SN - 0950-9232

IS - 10

ER -

ID: 18947121