Enterotypes of the human gut microbiome: [Plus]Corrigendum [Plus]Addendum

Research output: Contribution to journal › Journal article › Research › peer-review

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Enterotypes of the human gut microbiome : [Plus]Corrigendum [Plus]Addendum. / Arumugam, Manimozhiyan; Raes, Jeroen; Pelletier, Eric; Le Paslier, Denis; Yamada, Takuji; Mende, Daniel R; Fernandes, Gabriel R; Tap, Julien; Bruls, Thomas; Batto, Jean-Michel; dos Santos, Marcelo Bertalan Quintanilha; Borruel, Natalia; Casellas, Francesc; Fernandez, Leyden; Gautier, Laurent; Hansen, Torben; Hattori, Masahira; Hayashi, Tetsuya; Kleerebezem, Michiel; Kurokawa, Ken; Leclerc, Marion; Levenez, Florence; Manichanh, Chaysavanh; Nielsen, H Bjørn; Nielsen, Trine; Pons, Nicolas; Poulain, Julie; Qin, Junjie; Sicheritz-Ponten, Thomas; Tims, Sebastian; Torrents, David; Ugarte, Edgardo; Zoetendal, Erwin G; Wang, Jun; Guarner, Francisco; Pedersen, Oluf; de Vos, Willem M; Brunak, Søren; Doré, Joel; Antolín, María; Artiguenave, François; Blottiere, Hervé M; Almeida, Mathieu; Brechot, Christian; Cara, Carlos; Chervaux, Christian; Cultrone, Antonella; Delorme, Christine; Denariaz, Gérard; Kristiansen, Karsten; MetaHIT Consortium.

In: Nature, Vol. 473, No. 7346, 2011, p. 174-180.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Arumugam, M, Raes, J, Pelletier, E, Le Paslier, D, Yamada, T, Mende, DR, Fernandes, GR, Tap, J, Bruls, T, Batto, J-M, dos Santos, MBQ, Borruel, N, Casellas, F, Fernandez, L, Gautier, L, Hansen, T, Hattori, M, Hayashi, T, Kleerebezem, M, Kurokawa, K, Leclerc, M, Levenez, F, Manichanh, C, Nielsen, HB, Nielsen, T, Pons, N, Poulain, J, Qin, J, Sicheritz-Ponten, T, Tims, S, Torrents, D, Ugarte, E, Zoetendal, EG, Wang, J, Guarner, F, Pedersen, O, de Vos, WM, Brunak, S, Doré, J, Antolín, M, Artiguenave, F, Blottiere, HM, Almeida, M, Brechot, C, Cara, C, Chervaux, C, Cultrone, A, Delorme, C, Denariaz, G, Kristiansen, K & MetaHIT Consortium 2011, 'Enterotypes of the human gut microbiome: [Plus]Corrigendum [Plus]Addendum', Nature, vol. 473, no. 7346, pp. 174-180. https://doi.org/10.1038/nature09944, https://doi.org/10.1038/nature13075, https://doi.org/10.1038/nature10187

APA

Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., Batto, J-M., dos Santos, M. B. Q., Borruel, N., Casellas, F., Fernandez, L., Gautier, L., Hansen, T., Hattori, M., Hayashi, T., Kleerebezem, M., ... MetaHIT Consortium (2011). Enterotypes of the human gut microbiome: [Plus]Corrigendum [Plus]Addendum. Nature, 473(7346), 174-180. https://doi.org/10.1038/nature09944, https://doi.org/10.1038/nature13075, https://doi.org/10.1038/nature10187

Vancouver

Arumugam M, Raes J, Pelletier E, Le Paslier D, Yamada T, Mende DR et al. Enterotypes of the human gut microbiome: [Plus]Corrigendum [Plus]Addendum. Nature. 2011;473(7346):174-180. https://doi.org/10.1038/nature09944, https://doi.org/10.1038/nature13075, https://doi.org/10.1038/nature10187

Author

Arumugam, Manimozhiyan ; Raes, Jeroen ; Pelletier, Eric ; Le Paslier, Denis ; Yamada, Takuji ; Mende, Daniel R ; Fernandes, Gabriel R ; Tap, Julien ; Bruls, Thomas ; Batto, Jean-Michel ; dos Santos, Marcelo Bertalan Quintanilha ; Borruel, Natalia ; Casellas, Francesc ; Fernandez, Leyden ; Gautier, Laurent ; Hansen, Torben ; Hattori, Masahira ; Hayashi, Tetsuya ; Kleerebezem, Michiel ; Kurokawa, Ken ; Leclerc, Marion ; Levenez, Florence ; Manichanh, Chaysavanh ; Nielsen, H Bjørn ; Nielsen, Trine ; Pons, Nicolas ; Poulain, Julie ; Qin, Junjie ; Sicheritz-Ponten, Thomas ; Tims, Sebastian ; Torrents, David ; Ugarte, Edgardo ; Zoetendal, Erwin G ; Wang, Jun ; Guarner, Francisco ; Pedersen, Oluf ; de Vos, Willem M ; Brunak, Søren ; Doré, Joel ; Antolín, María ; Artiguenave, François ; Blottiere, Hervé M ; Almeida, Mathieu ; Brechot, Christian ; Cara, Carlos ; Chervaux, Christian ; Cultrone, Antonella ; Delorme, Christine ; Denariaz, Gérard ; Kristiansen, Karsten ; MetaHIT Consortium. / Enterotypes of the human gut microbiome : [Plus]Corrigendum [Plus]Addendum. In: Nature. 2011 ; Vol. 473, No. 7346. pp. 174-180.

Bibtex

@article{146f8efdf234471e8c1d25b41eb2328b,
title = "Enterotypes of the human gut microbiome: [Plus]Corrigendum [Plus]Addendum",
abstract = "Our knowledge of species and functional composition of the human gut microbiome is rapidly increasing, but it is still based on very few cohorts and little is known about variation across the world. By combining 22 newly sequenced faecal metagenomes of individuals from four countries with previously published data sets, here we identify three robust clusters (referred to as enterotypes hereafter) that are not nation or continent specific. We also confirmed the enterotypes in two published, larger cohorts, indicating that intestinal microbiota variation is generally stratified, not continuous. This indicates further the existence of a limited number of well-balanced host-microbial symbiotic states that might respond differently to diet and drug intake. The enterotypes are mostly driven by species composition, but abundant molecular functions are not necessarily provided by abundant species, highlighting the importance of a functional analysis to understand microbial communities. Although individual host properties such as body mass index, age, or gender cannot explain the observed enterotypes, data-driven marker genes or functional modules can be identified for each of these host properties. For example, twelve genes significantly correlate with age and three functional modules with the body mass index, hinting at a diagnostic potential of microbial markers.",
keywords = "Bacteria, Bacterial Typing Techniques, Biodiversity, Biological Markers, Europe, Feces, Female, Humans, Intestines, Male, Metagenome, Metagenomics, Phylogeny",
author = "Manimozhiyan Arumugam and Jeroen Raes and Eric Pelletier and {Le Paslier}, Denis and Takuji Yamada and Mende, {Daniel R} and Fernandes, {Gabriel R} and Julien Tap and Thomas Bruls and Jean-Michel Batto and {dos Santos}, {Marcelo Bertalan Quintanilha} and Natalia Borruel and Francesc Casellas and Leyden Fernandez and Laurent Gautier and Torben Hansen and Masahira Hattori and Tetsuya Hayashi and Michiel Kleerebezem and Ken Kurokawa and Marion Leclerc and Florence Levenez and Chaysavanh Manichanh and Nielsen, {H Bj{\o}rn} and Trine Nielsen and Nicolas Pons and Julie Poulain and Junjie Qin and Thomas Sicheritz-Ponten and Sebastian Tims and David Torrents and Edgardo Ugarte and Zoetendal, {Erwin G} and Jun Wang and Francisco Guarner and Oluf Pedersen and {de Vos}, {Willem M} and S{\o}ren Brunak and Joel Dor{\'e} and Mar{\'i}a Antol{\'i}n and Fran{\c c}ois Artiguenave and Blottiere, {Herv{\'e} M} and Mathieu Almeida and Christian Brechot and Carlos Cara and Christian Chervaux and Antonella Cultrone and Christine Delorme and G{\'e}rard Denariaz and Karsten Kristiansen and {MetaHIT Consortium}",
year = "2011",
doi = "10.1038/nature09944",
language = "English",
volume = "473",
pages = "174--180",
journal = "Nature",
issn = "0028-0836",
publisher = "nature publishing group",
number = "7346",

}

RIS

TY - JOUR

T1 - Enterotypes of the human gut microbiome

T2 - [Plus]Corrigendum [Plus]Addendum

AU - Arumugam, Manimozhiyan

AU - Raes, Jeroen

AU - Pelletier, Eric

AU - Le Paslier, Denis

AU - Yamada, Takuji

AU - Mende, Daniel R

AU - Fernandes, Gabriel R

AU - Tap, Julien

AU - Bruls, Thomas

AU - Batto, Jean-Michel

AU - dos Santos, Marcelo Bertalan Quintanilha

AU - Borruel, Natalia

AU - Casellas, Francesc

AU - Fernandez, Leyden

AU - Gautier, Laurent

AU - Hansen, Torben

AU - Hattori, Masahira

AU - Hayashi, Tetsuya

AU - Kleerebezem, Michiel

AU - Kurokawa, Ken

AU - Leclerc, Marion

AU - Levenez, Florence

AU - Manichanh, Chaysavanh

AU - Nielsen, H Bjørn

AU - Nielsen, Trine

AU - Pons, Nicolas

AU - Poulain, Julie

AU - Qin, Junjie

AU - Sicheritz-Ponten, Thomas

AU - Tims, Sebastian

AU - Torrents, David

AU - Ugarte, Edgardo

AU - Zoetendal, Erwin G

AU - Wang, Jun

AU - Guarner, Francisco

AU - Pedersen, Oluf

AU - de Vos, Willem M

AU - Brunak, Søren

AU - Doré, Joel

AU - Antolín, María

AU - Artiguenave, François

AU - Blottiere, Hervé M

AU - Almeida, Mathieu

AU - Brechot, Christian

AU - Cara, Carlos

AU - Chervaux, Christian

AU - Cultrone, Antonella

AU - Delorme, Christine

AU - Denariaz, Gérard

AU - Kristiansen, Karsten

AU - MetaHIT Consortium

PY - 2011

Y1 - 2011

N2 - Our knowledge of species and functional composition of the human gut microbiome is rapidly increasing, but it is still based on very few cohorts and little is known about variation across the world. By combining 22 newly sequenced faecal metagenomes of individuals from four countries with previously published data sets, here we identify three robust clusters (referred to as enterotypes hereafter) that are not nation or continent specific. We also confirmed the enterotypes in two published, larger cohorts, indicating that intestinal microbiota variation is generally stratified, not continuous. This indicates further the existence of a limited number of well-balanced host-microbial symbiotic states that might respond differently to diet and drug intake. The enterotypes are mostly driven by species composition, but abundant molecular functions are not necessarily provided by abundant species, highlighting the importance of a functional analysis to understand microbial communities. Although individual host properties such as body mass index, age, or gender cannot explain the observed enterotypes, data-driven marker genes or functional modules can be identified for each of these host properties. For example, twelve genes significantly correlate with age and three functional modules with the body mass index, hinting at a diagnostic potential of microbial markers.

AB - Our knowledge of species and functional composition of the human gut microbiome is rapidly increasing, but it is still based on very few cohorts and little is known about variation across the world. By combining 22 newly sequenced faecal metagenomes of individuals from four countries with previously published data sets, here we identify three robust clusters (referred to as enterotypes hereafter) that are not nation or continent specific. We also confirmed the enterotypes in two published, larger cohorts, indicating that intestinal microbiota variation is generally stratified, not continuous. This indicates further the existence of a limited number of well-balanced host-microbial symbiotic states that might respond differently to diet and drug intake. The enterotypes are mostly driven by species composition, but abundant molecular functions are not necessarily provided by abundant species, highlighting the importance of a functional analysis to understand microbial communities. Although individual host properties such as body mass index, age, or gender cannot explain the observed enterotypes, data-driven marker genes or functional modules can be identified for each of these host properties. For example, twelve genes significantly correlate with age and three functional modules with the body mass index, hinting at a diagnostic potential of microbial markers.

KW - Bacteria

KW - Bacterial Typing Techniques

KW - Biodiversity

KW - Biological Markers

KW - Europe

KW - Feces

KW - Female

KW - Humans

KW - Intestines

KW - Male

KW - Metagenome

KW - Metagenomics

KW - Phylogeny

U2 - 10.1038/nature09944

DO - 10.1038/nature09944

M3 - Journal article

C2 - 21508958

VL - 473

SP - 174

EP - 180

JO - Nature

JF - Nature

SN - 0028-0836

IS - 7346

ER -

ID: 35314622