Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor. / Dowsett, Joseph; Ferkingstad, Egil; Rasmussen, Line Jee Hartmann; Thørner, Lise Wegner; Magnússon, Magnús K; Sugden, Karen; Thorleifsson, Gudmar; Frigge, Mike; Burgdorf, Kristoffer Sølvsten; Ostrowski, Sisse Rye; Sørensen, Erik; Erikstrup, Christian; Pedersen, Ole Birger; Hansen, Thomas Folkmann; Banasik, Karina; Brunak, Søren; Tragante, Vinicius; Lund, Sigrun Helga; Stefansdottir, Lilja; Gunnarson, Bjarni; Poulton, Richie; Arseneault, Louise; Caspi, Avshalom; Moffitt, Terrie E; Gudbjartsson, Daníel; Eugen-Olsen, Jesper; Stefánsson, Hreinn; Stefánsson, Kári; Ullum, Henrik; DBDS Genomic Consortium.

In: Communications Biology , Vol. 4, No. 1, 2021, p. 655.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Dowsett, J, Ferkingstad, E, Rasmussen, LJH, Thørner, LW, Magnússon, MK, Sugden, K, Thorleifsson, G, Frigge, M, Burgdorf, KS, Ostrowski, SR, Sørensen, E, Erikstrup, C, Pedersen, OB, Hansen, TF, Banasik, K, Brunak, S, Tragante, V, Lund, SH, Stefansdottir, L, Gunnarson, B, Poulton, R, Arseneault, L, Caspi, A, Moffitt, TE, Gudbjartsson, D, Eugen-Olsen, J, Stefánsson, H, Stefánsson, K, Ullum, H & DBDS Genomic Consortium 2021, 'Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor', Communications Biology , vol. 4, no. 1, pp. 655. https://doi.org/10.1038/s42003-021-02144-8

APA

Dowsett, J., Ferkingstad, E., Rasmussen, L. J. H., Thørner, L. W., Magnússon, M. K., Sugden, K., Thorleifsson, G., Frigge, M., Burgdorf, K. S., Ostrowski, S. R., Sørensen, E., Erikstrup, C., Pedersen, O. B., Hansen, T. F., Banasik, K., Brunak, S., Tragante, V., Lund, S. H., Stefansdottir, L., ... DBDS Genomic Consortium (2021). Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor. Communications Biology , 4(1), 655. https://doi.org/10.1038/s42003-021-02144-8

Vancouver

Dowsett J, Ferkingstad E, Rasmussen LJH, Thørner LW, Magnússon MK, Sugden K et al. Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor. Communications Biology . 2021;4(1):655. https://doi.org/10.1038/s42003-021-02144-8

Author

Dowsett, Joseph ; Ferkingstad, Egil ; Rasmussen, Line Jee Hartmann ; Thørner, Lise Wegner ; Magnússon, Magnús K ; Sugden, Karen ; Thorleifsson, Gudmar ; Frigge, Mike ; Burgdorf, Kristoffer Sølvsten ; Ostrowski, Sisse Rye ; Sørensen, Erik ; Erikstrup, Christian ; Pedersen, Ole Birger ; Hansen, Thomas Folkmann ; Banasik, Karina ; Brunak, Søren ; Tragante, Vinicius ; Lund, Sigrun Helga ; Stefansdottir, Lilja ; Gunnarson, Bjarni ; Poulton, Richie ; Arseneault, Louise ; Caspi, Avshalom ; Moffitt, Terrie E ; Gudbjartsson, Daníel ; Eugen-Olsen, Jesper ; Stefánsson, Hreinn ; Stefánsson, Kári ; Ullum, Henrik ; DBDS Genomic Consortium. / Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor. In: Communications Biology . 2021 ; Vol. 4, No. 1. pp. 655.

Bibtex

@article{83386a4b46a8436cb10cf948615123ca,
title = "Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor",
abstract = "Soluble urokinase-type plasminogen activator receptor (suPAR) is a chronic inflammation marker associated with the development of a range of diseases, including cancer and cardiovascular disease. The genetics of suPAR remain unexplored but may shed light on the biology of the marker and its connection to outcomes. We report a heritability estimate of 60% for the variation in suPAR and performed a genome-wide association meta-analysis on suPAR levels measured in Iceland (N = 35,559) and in Denmark (N = 12,177). We identified 13 independently genome-wide significant sequence variants associated with suPAR across 11 distinct loci. Associated variants were found in and around genes encoding uPAR (PLAUR), its ligand uPA (PLAU), the kidney-disease-associated gene PLA2R1 as well as genes with relations to glycosylation, glycoprotein biosynthesis, and the immune response. These findings provide new insight into the causes of variation in suPAR plasma levels, which may clarify suPAR's potential role in associated diseases, as well as the underlying mechanisms that give suPAR its prognostic value as a unique marker of chronic inflammation.",
author = "Joseph Dowsett and Egil Ferkingstad and Rasmussen, {Line Jee Hartmann} and Th{\o}rner, {Lise Wegner} and Magn{\'u}sson, {Magn{\'u}s K} and Karen Sugden and Gudmar Thorleifsson and Mike Frigge and Burgdorf, {Kristoffer S{\o}lvsten} and Ostrowski, {Sisse Rye} and Erik S{\o}rensen and Christian Erikstrup and Pedersen, {Ole Birger} and Hansen, {Thomas Folkmann} and Karina Banasik and S{\o}ren Brunak and Vinicius Tragante and Lund, {Sigrun Helga} and Lilja Stefansdottir and Bjarni Gunnarson and Richie Poulton and Louise Arseneault and Avshalom Caspi and Moffitt, {Terrie E} and Dan{\'i}el Gudbjartsson and Jesper Eugen-Olsen and Hreinn Stef{\'a}nsson and K{\'a}ri Stef{\'a}nsson and Henrik Ullum and {DBDS Genomic Consortium}",
year = "2021",
doi = "10.1038/s42003-021-02144-8",
language = "English",
volume = "4",
pages = "655",
journal = "Communications Biology",
issn = "2399-3642",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor

AU - Dowsett, Joseph

AU - Ferkingstad, Egil

AU - Rasmussen, Line Jee Hartmann

AU - Thørner, Lise Wegner

AU - Magnússon, Magnús K

AU - Sugden, Karen

AU - Thorleifsson, Gudmar

AU - Frigge, Mike

AU - Burgdorf, Kristoffer Sølvsten

AU - Ostrowski, Sisse Rye

AU - Sørensen, Erik

AU - Erikstrup, Christian

AU - Pedersen, Ole Birger

AU - Hansen, Thomas Folkmann

AU - Banasik, Karina

AU - Brunak, Søren

AU - Tragante, Vinicius

AU - Lund, Sigrun Helga

AU - Stefansdottir, Lilja

AU - Gunnarson, Bjarni

AU - Poulton, Richie

AU - Arseneault, Louise

AU - Caspi, Avshalom

AU - Moffitt, Terrie E

AU - Gudbjartsson, Daníel

AU - Eugen-Olsen, Jesper

AU - Stefánsson, Hreinn

AU - Stefánsson, Kári

AU - Ullum, Henrik

AU - DBDS Genomic Consortium

PY - 2021

Y1 - 2021

N2 - Soluble urokinase-type plasminogen activator receptor (suPAR) is a chronic inflammation marker associated with the development of a range of diseases, including cancer and cardiovascular disease. The genetics of suPAR remain unexplored but may shed light on the biology of the marker and its connection to outcomes. We report a heritability estimate of 60% for the variation in suPAR and performed a genome-wide association meta-analysis on suPAR levels measured in Iceland (N = 35,559) and in Denmark (N = 12,177). We identified 13 independently genome-wide significant sequence variants associated with suPAR across 11 distinct loci. Associated variants were found in and around genes encoding uPAR (PLAUR), its ligand uPA (PLAU), the kidney-disease-associated gene PLA2R1 as well as genes with relations to glycosylation, glycoprotein biosynthesis, and the immune response. These findings provide new insight into the causes of variation in suPAR plasma levels, which may clarify suPAR's potential role in associated diseases, as well as the underlying mechanisms that give suPAR its prognostic value as a unique marker of chronic inflammation.

AB - Soluble urokinase-type plasminogen activator receptor (suPAR) is a chronic inflammation marker associated with the development of a range of diseases, including cancer and cardiovascular disease. The genetics of suPAR remain unexplored but may shed light on the biology of the marker and its connection to outcomes. We report a heritability estimate of 60% for the variation in suPAR and performed a genome-wide association meta-analysis on suPAR levels measured in Iceland (N = 35,559) and in Denmark (N = 12,177). We identified 13 independently genome-wide significant sequence variants associated with suPAR across 11 distinct loci. Associated variants were found in and around genes encoding uPAR (PLAUR), its ligand uPA (PLAU), the kidney-disease-associated gene PLA2R1 as well as genes with relations to glycosylation, glycoprotein biosynthesis, and the immune response. These findings provide new insight into the causes of variation in suPAR plasma levels, which may clarify suPAR's potential role in associated diseases, as well as the underlying mechanisms that give suPAR its prognostic value as a unique marker of chronic inflammation.

U2 - 10.1038/s42003-021-02144-8

DO - 10.1038/s42003-021-02144-8

M3 - Journal article

C2 - 34079037

VL - 4

SP - 655

JO - Communications Biology

JF - Communications Biology

SN - 2399-3642

IS - 1

ER -

ID: 271974919