Dynamics and stabilization of the human gut microbiome during the first year of life

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Dynamics and stabilization of the human gut microbiome during the first year of life. / Bäckhed, Gert Fredrik; Roswall, Josefine; Peng, Yangqing; Feng, Qiang; Jia, Huijue; Kovatcheva-Datchary, Petia; Li, Yin; Xia, Yan; Xie, Hailiang; Zhong, Huanzi; Khan, Muhammad Tanweer; Zhang, Jianfeng; Li, Junhua; Xiao, Liang; Al-Aama, Jumana; Zhang, Dongya; Lee, Ying Shiuan; Kotowska, Dorota Ewa; Colding, Camilla Skettrup; Tremaroli, Valentina; Yin, Ye; Bergman, Stefan; Xu, Xun; Madsen, Lise; Kristiansen, Karsten; Dahlgren, Jovanna; Wang, Jun.

In: Cell Host & Microbe, Vol. 17, No. 5, 2015, p. 690-703.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bäckhed, GF, Roswall, J, Peng, Y, Feng, Q, Jia, H, Kovatcheva-Datchary, P, Li, Y, Xia, Y, Xie, H, Zhong, H, Khan, MT, Zhang, J, Li, J, Xiao, L, Al-Aama, J, Zhang, D, Lee, YS, Kotowska, DE, Colding, CS, Tremaroli, V, Yin, Y, Bergman, S, Xu, X, Madsen, L, Kristiansen, K, Dahlgren, J & Wang, J 2015, 'Dynamics and stabilization of the human gut microbiome during the first year of life', Cell Host & Microbe, vol. 17, no. 5, pp. 690-703. https://doi.org/10.1016/j.chom.2015.04.004

APA

Bäckhed, G. F., Roswall, J., Peng, Y., Feng, Q., Jia, H., Kovatcheva-Datchary, P., Li, Y., Xia, Y., Xie, H., Zhong, H., Khan, M. T., Zhang, J., Li, J., Xiao, L., Al-Aama, J., Zhang, D., Lee, Y. S., Kotowska, D. E., Colding, C. S., ... Wang, J. (2015). Dynamics and stabilization of the human gut microbiome during the first year of life. Cell Host & Microbe, 17(5), 690-703. https://doi.org/10.1016/j.chom.2015.04.004

Vancouver

Bäckhed GF, Roswall J, Peng Y, Feng Q, Jia H, Kovatcheva-Datchary P et al. Dynamics and stabilization of the human gut microbiome during the first year of life. Cell Host & Microbe. 2015;17(5):690-703. https://doi.org/10.1016/j.chom.2015.04.004

Author

Bäckhed, Gert Fredrik ; Roswall, Josefine ; Peng, Yangqing ; Feng, Qiang ; Jia, Huijue ; Kovatcheva-Datchary, Petia ; Li, Yin ; Xia, Yan ; Xie, Hailiang ; Zhong, Huanzi ; Khan, Muhammad Tanweer ; Zhang, Jianfeng ; Li, Junhua ; Xiao, Liang ; Al-Aama, Jumana ; Zhang, Dongya ; Lee, Ying Shiuan ; Kotowska, Dorota Ewa ; Colding, Camilla Skettrup ; Tremaroli, Valentina ; Yin, Ye ; Bergman, Stefan ; Xu, Xun ; Madsen, Lise ; Kristiansen, Karsten ; Dahlgren, Jovanna ; Wang, Jun. / Dynamics and stabilization of the human gut microbiome during the first year of life. In: Cell Host & Microbe. 2015 ; Vol. 17, No. 5. pp. 690-703.

Bibtex

@article{5851fbca22214f04a57b7433ec72bf4e,
title = "Dynamics and stabilization of the human gut microbiome during the first year of life",
abstract = "The gut microbiota is central to human health, but its establishment in early life has not been quantitatively and functionally examined. Applying metagenomic analysis on fecal samples from a large cohort of Swedish infants and their mothers, we characterized the gut microbiome during the first year of life and assessed the impact of mode of delivery and feeding on its establishment. In contrast to vaginally delivered infants, the gut microbiota of infants delivered by C-section showed significantly less resemblance to their mothers. Nutrition had a major impact on early microbiota composition and function, with cessation of breast-feeding, rather than introduction of solid food, being required for maturation into an adult-like microbiota. Microbiota composition and ecological network had distinctive features at each sampled stage, in accordance with functional maturation of the microbiome. Our findings establish a framework for understanding the interplay between the gut microbiome and the human body in early life.",
author = "B{\"a}ckhed, {Gert Fredrik} and Josefine Roswall and Yangqing Peng and Qiang Feng and Huijue Jia and Petia Kovatcheva-Datchary and Yin Li and Yan Xia and Hailiang Xie and Huanzi Zhong and Khan, {Muhammad Tanweer} and Jianfeng Zhang and Junhua Li and Liang Xiao and Jumana Al-Aama and Dongya Zhang and Lee, {Ying Shiuan} and Kotowska, {Dorota Ewa} and Colding, {Camilla Skettrup} and Valentina Tremaroli and Ye Yin and Stefan Bergman and Xun Xu and Lise Madsen and Karsten Kristiansen and Jovanna Dahlgren and Jun Wang",
year = "2015",
doi = "10.1016/j.chom.2015.04.004",
language = "English",
volume = "17",
pages = "690--703",
journal = "Cell Host & Microbe",
issn = "1931-3128",
publisher = "Cell Press",
number = "5",

}

RIS

TY - JOUR

T1 - Dynamics and stabilization of the human gut microbiome during the first year of life

AU - Bäckhed, Gert Fredrik

AU - Roswall, Josefine

AU - Peng, Yangqing

AU - Feng, Qiang

AU - Jia, Huijue

AU - Kovatcheva-Datchary, Petia

AU - Li, Yin

AU - Xia, Yan

AU - Xie, Hailiang

AU - Zhong, Huanzi

AU - Khan, Muhammad Tanweer

AU - Zhang, Jianfeng

AU - Li, Junhua

AU - Xiao, Liang

AU - Al-Aama, Jumana

AU - Zhang, Dongya

AU - Lee, Ying Shiuan

AU - Kotowska, Dorota Ewa

AU - Colding, Camilla Skettrup

AU - Tremaroli, Valentina

AU - Yin, Ye

AU - Bergman, Stefan

AU - Xu, Xun

AU - Madsen, Lise

AU - Kristiansen, Karsten

AU - Dahlgren, Jovanna

AU - Wang, Jun

PY - 2015

Y1 - 2015

N2 - The gut microbiota is central to human health, but its establishment in early life has not been quantitatively and functionally examined. Applying metagenomic analysis on fecal samples from a large cohort of Swedish infants and their mothers, we characterized the gut microbiome during the first year of life and assessed the impact of mode of delivery and feeding on its establishment. In contrast to vaginally delivered infants, the gut microbiota of infants delivered by C-section showed significantly less resemblance to their mothers. Nutrition had a major impact on early microbiota composition and function, with cessation of breast-feeding, rather than introduction of solid food, being required for maturation into an adult-like microbiota. Microbiota composition and ecological network had distinctive features at each sampled stage, in accordance with functional maturation of the microbiome. Our findings establish a framework for understanding the interplay between the gut microbiome and the human body in early life.

AB - The gut microbiota is central to human health, but its establishment in early life has not been quantitatively and functionally examined. Applying metagenomic analysis on fecal samples from a large cohort of Swedish infants and their mothers, we characterized the gut microbiome during the first year of life and assessed the impact of mode of delivery and feeding on its establishment. In contrast to vaginally delivered infants, the gut microbiota of infants delivered by C-section showed significantly less resemblance to their mothers. Nutrition had a major impact on early microbiota composition and function, with cessation of breast-feeding, rather than introduction of solid food, being required for maturation into an adult-like microbiota. Microbiota composition and ecological network had distinctive features at each sampled stage, in accordance with functional maturation of the microbiome. Our findings establish a framework for understanding the interplay between the gut microbiome and the human body in early life.

U2 - 10.1016/j.chom.2015.04.004

DO - 10.1016/j.chom.2015.04.004

M3 - Journal article

C2 - 25974306

VL - 17

SP - 690

EP - 703

JO - Cell Host & Microbe

JF - Cell Host & Microbe

SN - 1931-3128

IS - 5

ER -

ID: 141046672