Dual association of a TRKA polymorphism with schizophrenia
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OBJECTIVE: An interaction between predisposing genes and environmental stressors is thought to underlie the neurodevelopmental disorder schizophrenia. In a targeted gene screening, we previously found that the minor allele of the single nucleotide polymorphism (SNP) rs6336 in the neurotrophic tyrosine kinase receptor 1 (NTRK1/TRKA) gene is associated with schizophrenia as a risk factor. METHODS: We genotyped the TRKA SNP in a total of eight independent Caucasian schizophrenia case-control groups. RESULT: Remarkably, although in five of the groups a higher frequency of the risk allele was indeed found in the patients compared with the controls, in the three other groups the SNP acted as a protective factor. CONCLUSION: An intriguing possibility is that this dual character of the TRKA SNP is caused by its interaction with endophenotypic and/or epistatic factors.
Original language | English |
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Journal | Psychiatric Genetics |
Volume | 21 |
Issue number | 3 |
Pages (from-to) | 125-31 |
Number of pages | 7 |
ISSN | 0955-8829 |
DOIs | |
Publication status | Published - 2011 |
ID: 34053398