Comparative analysis of the functional genome architecture of animal and plant cell nuclei.
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Comparative analysis of the functional genome architecture of animal and plant cell nuclei. / Mayr, Christoph; Jasencakova, Zusana; Meister, Armin; Schubert, Ingo; Zink, Daniele.
In: Chromosome Research, Vol. 11, No. 5, 2003, p. 471-84.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Comparative analysis of the functional genome architecture of animal and plant cell nuclei.
AU - Mayr, Christoph
AU - Jasencakova, Zusana
AU - Meister, Armin
AU - Schubert, Ingo
AU - Zink, Daniele
N1 - Keywords: Animals; Bromodeoxyuridine; CHO Cells; Cell Nucleus; Chromatin; Cricetinae; Cricetulus; DNA, Satellite; Evolution, Molecular; Genome; Histones; Immunohistochemistry; In Situ Hybridization; Plants
PY - 2003
Y1 - 2003
N2 - Many studies have shown that the functional architecture of eukaryotic genomes displays striking similarities in evolutionarily distant organisms. For example, late-replicating and transcriptionally inactive chromatin is associated with the nuclear periphery in organisms as different as budding yeast and man. These findings suggest that eukaryotic genomes are organized in cell nuclei according to conserved principles. In order to investigate this, we examined nuclei of different animal and plant species by comparing replicational pulse-labelling patterns and their topological relationship to markers for heterochromatin and euchromatin. The data show great similarities in the nuclear genome organization of the investigated animal and plant species, supporting the idea that eukaryotic genomes are organized according to conserved principles. There are, however, differences between animals and plants with regard to histone acetylation patterns and the nuclear distribution of late-replicating chromatin.
AB - Many studies have shown that the functional architecture of eukaryotic genomes displays striking similarities in evolutionarily distant organisms. For example, late-replicating and transcriptionally inactive chromatin is associated with the nuclear periphery in organisms as different as budding yeast and man. These findings suggest that eukaryotic genomes are organized in cell nuclei according to conserved principles. In order to investigate this, we examined nuclei of different animal and plant species by comparing replicational pulse-labelling patterns and their topological relationship to markers for heterochromatin and euchromatin. The data show great similarities in the nuclear genome organization of the investigated animal and plant species, supporting the idea that eukaryotic genomes are organized according to conserved principles. There are, however, differences between animals and plants with regard to histone acetylation patterns and the nuclear distribution of late-replicating chromatin.
M3 - Journal article
C2 - 12971723
VL - 11
SP - 471
EP - 484
JO - Chromosome Research
JF - Chromosome Research
SN - 0967-3849
IS - 5
ER -
ID: 5014183