Combing the Hairball: Improving Visualization of miRNA-Target Interaction Networks
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Combing the Hairball : Improving Visualization of miRNA-Target Interaction Networks. / Russo, Francesco; Hu, Jessica Xin; Romero Herrera, Jose Alejandro; Brunak, Søren.
MicroRNA Target Identification: Methods and Protocols. ed. / Alessandro Laganà. Humana Press, 2019. p. 279-289 (Methods in Molecular Biology, Vol. 1970).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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TY - CHAP
T1 - Combing the Hairball
T2 - Improving Visualization of miRNA-Target Interaction Networks
AU - Russo, Francesco
AU - Hu, Jessica Xin
AU - Romero Herrera, Jose Alejandro
AU - Brunak, Søren
PY - 2019
Y1 - 2019
N2 - The visualization of regulatory networks is becoming increasingly important in order to understand molecular mechanisms and diseases. MicroRNAs (miRNAs) are small noncoding RNAs (ncRNAs) responsible of the post-transcriptional regulation of messenger RNAs (mRNAs) and other ncRNAs. MiRNAs are involved in numerous biological processes including development, cell proliferation, and apoptosis. They are also key molecules in major complex diseases such as cancer and cardiovascular diseases. A single miRNA can regulate many targets, making the analysis and visualization of these complex networks challenging. Here, we present standard and advanced visualization approaches to represent networks with a special focus on miRNA-target interactions.
AB - The visualization of regulatory networks is becoming increasingly important in order to understand molecular mechanisms and diseases. MicroRNAs (miRNAs) are small noncoding RNAs (ncRNAs) responsible of the post-transcriptional regulation of messenger RNAs (mRNAs) and other ncRNAs. MiRNAs are involved in numerous biological processes including development, cell proliferation, and apoptosis. They are also key molecules in major complex diseases such as cancer and cardiovascular diseases. A single miRNA can regulate many targets, making the analysis and visualization of these complex networks challenging. Here, we present standard and advanced visualization approaches to represent networks with a special focus on miRNA-target interactions.
U2 - 10.1007/978-1-4939-9207-2_15
DO - 10.1007/978-1-4939-9207-2_15
M3 - Book chapter
C2 - 30963498
SN - 978-1-4939-9206-5
T3 - Methods in Molecular Biology
SP - 279
EP - 289
BT - MicroRNA Target Identification
A2 - Laganà, Alessandro
PB - Humana Press
ER -
ID: 224024363