Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans. / Holdt, Lesca M; Stahringer, Anika; Sass, Kristina; Pichler, Garwin; Kulak, Nils A; Wilfert, Wolfgang; Kohlmaier, Alexander; Herbst, Andreas; Northoff, Bernd H; Nicolaou, Alexandros; Gäbel, Gabor; Beutner, Frank; Scholz, Markus; Thiery, Joachim; Musunuru, Kiran; Krohn, Knut; Mann, Matthias; Teupser, Daniel.

In: Nature Communications, Vol. 7, 19.08.2016, p. 12429.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Holdt, LM, Stahringer, A, Sass, K, Pichler, G, Kulak, NA, Wilfert, W, Kohlmaier, A, Herbst, A, Northoff, BH, Nicolaou, A, Gäbel, G, Beutner, F, Scholz, M, Thiery, J, Musunuru, K, Krohn, K, Mann, M & Teupser, D 2016, 'Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans', Nature Communications, vol. 7, pp. 12429. https://doi.org/10.1038/ncomms12429

APA

Holdt, L. M., Stahringer, A., Sass, K., Pichler, G., Kulak, N. A., Wilfert, W., Kohlmaier, A., Herbst, A., Northoff, B. H., Nicolaou, A., Gäbel, G., Beutner, F., Scholz, M., Thiery, J., Musunuru, K., Krohn, K., Mann, M., & Teupser, D. (2016). Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans. Nature Communications, 7, 12429. https://doi.org/10.1038/ncomms12429

Vancouver

Holdt LM, Stahringer A, Sass K, Pichler G, Kulak NA, Wilfert W et al. Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans. Nature Communications. 2016 Aug 19;7:12429. https://doi.org/10.1038/ncomms12429

Author

Holdt, Lesca M ; Stahringer, Anika ; Sass, Kristina ; Pichler, Garwin ; Kulak, Nils A ; Wilfert, Wolfgang ; Kohlmaier, Alexander ; Herbst, Andreas ; Northoff, Bernd H ; Nicolaou, Alexandros ; Gäbel, Gabor ; Beutner, Frank ; Scholz, Markus ; Thiery, Joachim ; Musunuru, Kiran ; Krohn, Knut ; Mann, Matthias ; Teupser, Daniel. / Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans. In: Nature Communications. 2016 ; Vol. 7. pp. 12429.

Bibtex

@article{011dd2ebb50840c59180bfd0a063adba,
title = "Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans",
abstract = "Circular RNAs (circRNAs) are broadly expressed in eukaryotic cells, but their molecular mechanism in human disease remains obscure. Here we show that circular antisense non-coding RNA in the INK4 locus (circANRIL), which is transcribed at a locus of atherosclerotic cardiovascular disease on chromosome 9p21, confers atheroprotection by controlling ribosomal RNA (rRNA) maturation and modulating pathways of atherogenesis. CircANRIL binds to pescadillo homologue 1 (PES1), an essential 60S-preribosomal assembly factor, thereby impairing exonuclease-mediated pre-rRNA processing and ribosome biogenesis in vascular smooth muscle cells and macrophages. As a consequence, circANRIL induces nucleolar stress and p53 activation, resulting in the induction of apoptosis and inhibition of proliferation, which are key cell functions in atherosclerosis. Collectively, these findings identify circANRIL as a prototype of a circRNA regulating ribosome biogenesis and conferring atheroprotection, thereby showing that circularization of long non-coding RNAs may alter RNA function and protect from human disease.",
keywords = "Journal Article",
author = "Holdt, {Lesca M} and Anika Stahringer and Kristina Sass and Garwin Pichler and Kulak, {Nils A} and Wolfgang Wilfert and Alexander Kohlmaier and Andreas Herbst and Northoff, {Bernd H} and Alexandros Nicolaou and Gabor G{\"a}bel and Frank Beutner and Markus Scholz and Joachim Thiery and Kiran Musunuru and Knut Krohn and Matthias Mann and Daniel Teupser",
year = "2016",
month = aug,
day = "19",
doi = "10.1038/ncomms12429",
language = "English",
volume = "7",
pages = "12429",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans

AU - Holdt, Lesca M

AU - Stahringer, Anika

AU - Sass, Kristina

AU - Pichler, Garwin

AU - Kulak, Nils A

AU - Wilfert, Wolfgang

AU - Kohlmaier, Alexander

AU - Herbst, Andreas

AU - Northoff, Bernd H

AU - Nicolaou, Alexandros

AU - Gäbel, Gabor

AU - Beutner, Frank

AU - Scholz, Markus

AU - Thiery, Joachim

AU - Musunuru, Kiran

AU - Krohn, Knut

AU - Mann, Matthias

AU - Teupser, Daniel

PY - 2016/8/19

Y1 - 2016/8/19

N2 - Circular RNAs (circRNAs) are broadly expressed in eukaryotic cells, but their molecular mechanism in human disease remains obscure. Here we show that circular antisense non-coding RNA in the INK4 locus (circANRIL), which is transcribed at a locus of atherosclerotic cardiovascular disease on chromosome 9p21, confers atheroprotection by controlling ribosomal RNA (rRNA) maturation and modulating pathways of atherogenesis. CircANRIL binds to pescadillo homologue 1 (PES1), an essential 60S-preribosomal assembly factor, thereby impairing exonuclease-mediated pre-rRNA processing and ribosome biogenesis in vascular smooth muscle cells and macrophages. As a consequence, circANRIL induces nucleolar stress and p53 activation, resulting in the induction of apoptosis and inhibition of proliferation, which are key cell functions in atherosclerosis. Collectively, these findings identify circANRIL as a prototype of a circRNA regulating ribosome biogenesis and conferring atheroprotection, thereby showing that circularization of long non-coding RNAs may alter RNA function and protect from human disease.

AB - Circular RNAs (circRNAs) are broadly expressed in eukaryotic cells, but their molecular mechanism in human disease remains obscure. Here we show that circular antisense non-coding RNA in the INK4 locus (circANRIL), which is transcribed at a locus of atherosclerotic cardiovascular disease on chromosome 9p21, confers atheroprotection by controlling ribosomal RNA (rRNA) maturation and modulating pathways of atherogenesis. CircANRIL binds to pescadillo homologue 1 (PES1), an essential 60S-preribosomal assembly factor, thereby impairing exonuclease-mediated pre-rRNA processing and ribosome biogenesis in vascular smooth muscle cells and macrophages. As a consequence, circANRIL induces nucleolar stress and p53 activation, resulting in the induction of apoptosis and inhibition of proliferation, which are key cell functions in atherosclerosis. Collectively, these findings identify circANRIL as a prototype of a circRNA regulating ribosome biogenesis and conferring atheroprotection, thereby showing that circularization of long non-coding RNAs may alter RNA function and protect from human disease.

KW - Journal Article

U2 - 10.1038/ncomms12429

DO - 10.1038/ncomms12429

M3 - Journal article

C2 - 27539542

VL - 7

SP - 12429

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

ER -

ID: 184324592