Catching Lipid Droplet Contacts by Proteomics

Research output: Contribution to journal › Review › Research › peer-review

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Catching Lipid Droplet Contacts by Proteomics. / Krahmer, Natalie; Mann, Matthias.

In: Contact, Vol. 2, 2019, p. 1-8.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Krahmer, N & Mann, M 2019, 'Catching Lipid Droplet Contacts by Proteomics', Contact, vol. 2, pp. 1-8. https://doi.org/10.1177/2515256419859186

APA

Krahmer, N., & Mann, M. (2019). Catching Lipid Droplet Contacts by Proteomics. Contact, 2, 1-8. https://doi.org/10.1177/2515256419859186

Vancouver

Krahmer N, Mann M. Catching Lipid Droplet Contacts by Proteomics. Contact. 2019;2:1-8. https://doi.org/10.1177/2515256419859186

Author

Krahmer, Natalie ; Mann, Matthias. / Catching Lipid Droplet Contacts by Proteomics. In: Contact. 2019 ; Vol. 2. pp. 1-8.

Bibtex

@article{b0eeff3501814912a94b2fad83e98324,
title = "Catching Lipid Droplet Contacts by Proteomics",
abstract = "Lipid droplets (LDs), important organelles for energy storage and involved in the development of metabolic disorders, are extremely dynamic and interact with many other cellular compartments to orchestrate lipid metabolism. Little is known about how these organelle contacts are changed according to cellular needs and functions under different metabolic and pathological conditions and which proteins regulate this. Here, we summarize recent exciting discoveries about the reorganization of organelle contacts in steatotic liver, including the identification of novel LD contact site proteins in cell lines and in animals. We also discuss state of the art proteomics workflows that enable the characterization of LD-organelle contacts and tethering proteins and give an outlook how this can inform obesity research.",
author = "Natalie Krahmer and Matthias Mann",
year = "2019",
doi = "10.1177/2515256419859186",
language = "English",
volume = "2",
pages = "1--8",
journal = "Contact",
issn = "2515-2564",
publisher = "Sage Journals",

}

RIS

TY - JOUR

T1 - Catching Lipid Droplet Contacts by Proteomics

AU - Krahmer, Natalie

AU - Mann, Matthias

PY - 2019

Y1 - 2019

N2 - Lipid droplets (LDs), important organelles for energy storage and involved in the development of metabolic disorders, are extremely dynamic and interact with many other cellular compartments to orchestrate lipid metabolism. Little is known about how these organelle contacts are changed according to cellular needs and functions under different metabolic and pathological conditions and which proteins regulate this. Here, we summarize recent exciting discoveries about the reorganization of organelle contacts in steatotic liver, including the identification of novel LD contact site proteins in cell lines and in animals. We also discuss state of the art proteomics workflows that enable the characterization of LD-organelle contacts and tethering proteins and give an outlook how this can inform obesity research.

AB - Lipid droplets (LDs), important organelles for energy storage and involved in the development of metabolic disorders, are extremely dynamic and interact with many other cellular compartments to orchestrate lipid metabolism. Little is known about how these organelle contacts are changed according to cellular needs and functions under different metabolic and pathological conditions and which proteins regulate this. Here, we summarize recent exciting discoveries about the reorganization of organelle contacts in steatotic liver, including the identification of novel LD contact site proteins in cell lines and in animals. We also discuss state of the art proteomics workflows that enable the characterization of LD-organelle contacts and tethering proteins and give an outlook how this can inform obesity research.

U2 - 10.1177/2515256419859186

DO - 10.1177/2515256419859186

M3 - Review

C2 - 31355355

VL - 2

SP - 1

EP - 8

JO - Contact

JF - Contact

SN - 2515-2564

ER -

ID: 229857654