Bicycle exercise enhances plasma IL-6 but does not change IL-1α, IL-1β, IL-6, or TNF-α pre-mRNA in BMNC
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Bicycle exercise enhances plasma IL-6 but does not change IL-1α, IL-1β, IL-6, or TNF-α pre-mRNA in BMNC. / Ullum, H.; Haahr, P. M.; Diamant, M.; Palmo, J.; Halkjaer-Kristensen, J.; Pedersen, B. K.
In: Journal of Applied Physiology, Vol. 77, No. 1, 1994, p. 93-97.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Bicycle exercise enhances plasma IL-6 but does not change IL-1α, IL-1β, IL-6, or TNF-α pre-mRNA in BMNC
AU - Ullum, H.
AU - Haahr, P. M.
AU - Diamant, M.
AU - Palmo, J.
AU - Halkjaer-Kristensen, J.
AU - Pedersen, B. K.
PY - 1994
Y1 - 1994
N2 - The present study investigated the effect of concentric exercise on cytokine plasma levels and cytokine pre-mRNA in blood mononuclear cells (BMNCs). Healthy young moderately trained men performed ergometer bicycle exercise for 1 h at 75% of maximal oxygen uptake. The levels of plasma interleukin (IL)-6 increased significantly during exercise, but plasma levels of IL-1α, IL-1β, and tumor necrosis factor-α (TNF-α) were below the detection limit in most subjects. Pre-mRNA for IL-1α, IL-1β, IL-6, and TNF- α could be detected in BMNCs, but the amounts did not change in relation to exercise. These results indicate that, although the absolute number of monocytes increases during exercise and the percentage of CD14+/HLA-DR+ and CD14+/HLA-DR- monocytes increases after exercise, the increased plasma levels of IL-6 during exercise is not likely to be a result of activated monocytes in peripheral blood.
AB - The present study investigated the effect of concentric exercise on cytokine plasma levels and cytokine pre-mRNA in blood mononuclear cells (BMNCs). Healthy young moderately trained men performed ergometer bicycle exercise for 1 h at 75% of maximal oxygen uptake. The levels of plasma interleukin (IL)-6 increased significantly during exercise, but plasma levels of IL-1α, IL-1β, and tumor necrosis factor-α (TNF-α) were below the detection limit in most subjects. Pre-mRNA for IL-1α, IL-1β, IL-6, and TNF- α could be detected in BMNCs, but the amounts did not change in relation to exercise. These results indicate that, although the absolute number of monocytes increases during exercise and the percentage of CD14+/HLA-DR+ and CD14+/HLA-DR- monocytes increases after exercise, the increased plasma levels of IL-6 during exercise is not likely to be a result of activated monocytes in peripheral blood.
KW - cytokines
KW - immunology
KW - lymphocytes
KW - monocytes
KW - sport
KW - stress
U2 - 10.1152/jappl.1994.77.1.93
DO - 10.1152/jappl.1994.77.1.93
M3 - Journal article
C2 - 7961280
AN - SCOPUS:0028276385
VL - 77
SP - 93
EP - 97
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
SN - 8750-7587
IS - 1
ER -
ID: 203592864