An atlas of genetic determinants of forearm fracture

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

An atlas of genetic determinants of forearm fracture. / Nethander, Maria; Movérare-Skrtic, Sofia; Kämpe, Anders; Coward, Eivind; Reimann, Ene; Grahnemo, Louise; Borbély, Éva; Helyes, Zsuzsanna; Funck-Brentano, Thomas; Cohen-Solal, Martine; Tuukkanen, Juha; Koskela, Antti; Wu, Jianyao; Li, Lei; Lu, Tianyuan; Gabrielsen, Maiken E.; Mägi, Reedik; Hoff, Mari; Lerner, Ulf H.; Henning, Petra; Ullum, Henrik; Erikstrup, Christian; Brunak, Søren; Langhammer, Arnulf; Tuomi, Tiinamaija; Oddsson, Asmundur; Stefansson, Kari; Pettersson-Kymmer, Ulrika; Ostrowski, Sisse Rye; Pedersen, Ole Birger Vesterager; Styrkarsdottir, Unnur; Mäkitie, Outi; Hveem, Kristian; Richards, J. Brent; Ohlsson, Claes.

In: Nature Genetics, Vol. 55, No. 11, 2023, p. 1820-1830.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nethander, M, Movérare-Skrtic, S, Kämpe, A, Coward, E, Reimann, E, Grahnemo, L, Borbély, É, Helyes, Z, Funck-Brentano, T, Cohen-Solal, M, Tuukkanen, J, Koskela, A, Wu, J, Li, L, Lu, T, Gabrielsen, ME, Mägi, R, Hoff, M, Lerner, UH, Henning, P, Ullum, H, Erikstrup, C, Brunak, S, Langhammer, A, Tuomi, T, Oddsson, A, Stefansson, K, Pettersson-Kymmer, U, Ostrowski, SR, Pedersen, OBV, Styrkarsdottir, U, Mäkitie, O, Hveem, K, Richards, JB & Ohlsson, C 2023, 'An atlas of genetic determinants of forearm fracture', Nature Genetics, vol. 55, no. 11, pp. 1820-1830. https://doi.org/10.1038/s41588-023-01527-3

APA

Nethander, M., Movérare-Skrtic, S., Kämpe, A., Coward, E., Reimann, E., Grahnemo, L., Borbély, É., Helyes, Z., Funck-Brentano, T., Cohen-Solal, M., Tuukkanen, J., Koskela, A., Wu, J., Li, L., Lu, T., Gabrielsen, M. E., Mägi, R., Hoff, M., Lerner, U. H., ... Ohlsson, C. (2023). An atlas of genetic determinants of forearm fracture. Nature Genetics, 55(11), 1820-1830. https://doi.org/10.1038/s41588-023-01527-3

Vancouver

Nethander M, Movérare-Skrtic S, Kämpe A, Coward E, Reimann E, Grahnemo L et al. An atlas of genetic determinants of forearm fracture. Nature Genetics. 2023;55(11):1820-1830. https://doi.org/10.1038/s41588-023-01527-3

Author

Nethander, Maria ; Movérare-Skrtic, Sofia ; Kämpe, Anders ; Coward, Eivind ; Reimann, Ene ; Grahnemo, Louise ; Borbély, Éva ; Helyes, Zsuzsanna ; Funck-Brentano, Thomas ; Cohen-Solal, Martine ; Tuukkanen, Juha ; Koskela, Antti ; Wu, Jianyao ; Li, Lei ; Lu, Tianyuan ; Gabrielsen, Maiken E. ; Mägi, Reedik ; Hoff, Mari ; Lerner, Ulf H. ; Henning, Petra ; Ullum, Henrik ; Erikstrup, Christian ; Brunak, Søren ; Langhammer, Arnulf ; Tuomi, Tiinamaija ; Oddsson, Asmundur ; Stefansson, Kari ; Pettersson-Kymmer, Ulrika ; Ostrowski, Sisse Rye ; Pedersen, Ole Birger Vesterager ; Styrkarsdottir, Unnur ; Mäkitie, Outi ; Hveem, Kristian ; Richards, J. Brent ; Ohlsson, Claes. / An atlas of genetic determinants of forearm fracture. In: Nature Genetics. 2023 ; Vol. 55, No. 11. pp. 1820-1830.

Bibtex

@article{181a6c3209154cecb6a4946e1a72f3f5,
title = "An atlas of genetic determinants of forearm fracture",
abstract = "Osteoporotic fracture is among the most common and costly of diseases. While reasonably heritable, its genetic determinants have remained elusive. Forearm fractures are the most common clinically recognized osteoporotic fractures with a relatively high heritability. To establish an atlas of the genetic determinants of forearm fractures, we performed genome-wide association analyses including 100,026 forearm fracture cases. We identified 43 loci, including 26 new fracture loci. Although most fracture loci associated with bone mineral density, we also identified loci that primarily regulate bone quality parameters. Functional studies of one such locus, at TAC4, revealed that Tac4 –/– mice have reduced mechanical bone strength. The strongest forearm fracture signal, at WNT16, displayed remarkable bone-site-specificity with no association with hip fractures. Tall stature and low body mass index were identified as new causal risk factors for fractures. The insights from this atlas may improve fracture prediction and enable therapeutic development to prevent fractures.",
author = "Maria Nethander and Sofia Mov{\'e}rare-Skrtic and Anders K{\"a}mpe and Eivind Coward and Ene Reimann and Louise Grahnemo and {\'E}va Borb{\'e}ly and Zsuzsanna Helyes and Thomas Funck-Brentano and Martine Cohen-Solal and Juha Tuukkanen and Antti Koskela and Jianyao Wu and Lei Li and Tianyuan Lu and Gabrielsen, {Maiken E.} and Reedik M{\"a}gi and Mari Hoff and Lerner, {Ulf H.} and Petra Henning and Henrik Ullum and Christian Erikstrup and S{\o}ren Brunak and Arnulf Langhammer and Tiinamaija Tuomi and Asmundur Oddsson and Kari Stefansson and Ulrika Pettersson-Kymmer and Ostrowski, {Sisse Rye} and Pedersen, {Ole Birger Vesterager} and Unnur Styrkarsdottir and Outi M{\"a}kitie and Kristian Hveem and Richards, {J. Brent} and Claes Ohlsson",
note = "Publisher Copyright: {\textcopyright} 2023, The Author(s).",
year = "2023",
doi = "10.1038/s41588-023-01527-3",
language = "English",
volume = "55",
pages = "1820--1830",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "11",

}

RIS

TY - JOUR

T1 - An atlas of genetic determinants of forearm fracture

AU - Nethander, Maria

AU - Movérare-Skrtic, Sofia

AU - Kämpe, Anders

AU - Coward, Eivind

AU - Reimann, Ene

AU - Grahnemo, Louise

AU - Borbély, Éva

AU - Helyes, Zsuzsanna

AU - Funck-Brentano, Thomas

AU - Cohen-Solal, Martine

AU - Tuukkanen, Juha

AU - Koskela, Antti

AU - Wu, Jianyao

AU - Li, Lei

AU - Lu, Tianyuan

AU - Gabrielsen, Maiken E.

AU - Mägi, Reedik

AU - Hoff, Mari

AU - Lerner, Ulf H.

AU - Henning, Petra

AU - Ullum, Henrik

AU - Erikstrup, Christian

AU - Brunak, Søren

AU - Langhammer, Arnulf

AU - Tuomi, Tiinamaija

AU - Oddsson, Asmundur

AU - Stefansson, Kari

AU - Pettersson-Kymmer, Ulrika

AU - Ostrowski, Sisse Rye

AU - Pedersen, Ole Birger Vesterager

AU - Styrkarsdottir, Unnur

AU - Mäkitie, Outi

AU - Hveem, Kristian

AU - Richards, J. Brent

AU - Ohlsson, Claes

N1 - Publisher Copyright: © 2023, The Author(s).

PY - 2023

Y1 - 2023

N2 - Osteoporotic fracture is among the most common and costly of diseases. While reasonably heritable, its genetic determinants have remained elusive. Forearm fractures are the most common clinically recognized osteoporotic fractures with a relatively high heritability. To establish an atlas of the genetic determinants of forearm fractures, we performed genome-wide association analyses including 100,026 forearm fracture cases. We identified 43 loci, including 26 new fracture loci. Although most fracture loci associated with bone mineral density, we also identified loci that primarily regulate bone quality parameters. Functional studies of one such locus, at TAC4, revealed that Tac4 –/– mice have reduced mechanical bone strength. The strongest forearm fracture signal, at WNT16, displayed remarkable bone-site-specificity with no association with hip fractures. Tall stature and low body mass index were identified as new causal risk factors for fractures. The insights from this atlas may improve fracture prediction and enable therapeutic development to prevent fractures.

AB - Osteoporotic fracture is among the most common and costly of diseases. While reasonably heritable, its genetic determinants have remained elusive. Forearm fractures are the most common clinically recognized osteoporotic fractures with a relatively high heritability. To establish an atlas of the genetic determinants of forearm fractures, we performed genome-wide association analyses including 100,026 forearm fracture cases. We identified 43 loci, including 26 new fracture loci. Although most fracture loci associated with bone mineral density, we also identified loci that primarily regulate bone quality parameters. Functional studies of one such locus, at TAC4, revealed that Tac4 –/– mice have reduced mechanical bone strength. The strongest forearm fracture signal, at WNT16, displayed remarkable bone-site-specificity with no association with hip fractures. Tall stature and low body mass index were identified as new causal risk factors for fractures. The insights from this atlas may improve fracture prediction and enable therapeutic development to prevent fractures.

U2 - 10.1038/s41588-023-01527-3

DO - 10.1038/s41588-023-01527-3

M3 - Journal article

C2 - 37919453

AN - SCOPUS:85175830637

VL - 55

SP - 1820

EP - 1830

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 11

ER -

ID: 372960349