A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape
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A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape. / Hubel, Philipp; Urban, Christian; Bergant, Valter; Schneider, William M; Knauer, Barbara; Stukalov, Alexey; Scaturro, Pietro; Mann, Angelika; Brunotte, Linda; Hoffmann, Heinrich H; Schoggins, John W; Schwemmle, Martin; Mann, Matthias; Rice, Charles M; Pichlmair, Andreas.
In: Nature Immunology, 04.03.2019.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape
AU - Hubel, Philipp
AU - Urban, Christian
AU - Bergant, Valter
AU - Schneider, William M
AU - Knauer, Barbara
AU - Stukalov, Alexey
AU - Scaturro, Pietro
AU - Mann, Angelika
AU - Brunotte, Linda
AU - Hoffmann, Heinrich H
AU - Schoggins, John W
AU - Schwemmle, Martin
AU - Mann, Matthias
AU - Rice, Charles M
AU - Pichlmair, Andreas
PY - 2019/3/4
Y1 - 2019/3/4
N2 - Interferon-stimulated genes (ISGs) form the backbone of the innate immune system and are important for limiting intra- and intercellular viral replication and spread. We conducted a mass-spectrometry-based survey to understand the fundamental organization of the innate immune system and to explore the molecular functions of individual ISGs. We identified interactions between 104 ISGs and 1,401 cellular binding partners engaging in 2,734 high-confidence interactions. 90% of these interactions are unreported so far, and our survey therefore illuminates a far wider activity spectrum of ISGs than is currently known. Integration of the resulting ISG-interaction network with published datasets and functional studies allowed us to identify regulators of immunity and processes related to the immune system. Given the extraordinary robustness of the innate immune system, this ISG network may serve as a blueprint for therapeutic targeting of cellular systems to efficiently fight viral infections.
AB - Interferon-stimulated genes (ISGs) form the backbone of the innate immune system and are important for limiting intra- and intercellular viral replication and spread. We conducted a mass-spectrometry-based survey to understand the fundamental organization of the innate immune system and to explore the molecular functions of individual ISGs. We identified interactions between 104 ISGs and 1,401 cellular binding partners engaging in 2,734 high-confidence interactions. 90% of these interactions are unreported so far, and our survey therefore illuminates a far wider activity spectrum of ISGs than is currently known. Integration of the resulting ISG-interaction network with published datasets and functional studies allowed us to identify regulators of immunity and processes related to the immune system. Given the extraordinary robustness of the innate immune system, this ISG network may serve as a blueprint for therapeutic targeting of cellular systems to efficiently fight viral infections.
U2 - 10.1038/s41590-019-0323-3
DO - 10.1038/s41590-019-0323-3
M3 - Journal article
C2 - 30833792
JO - Nature Immunology
JF - Nature Immunology
SN - 1529-2908
ER -
ID: 214462915