A lncRNA to repair DNA
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A lncRNA to repair DNA. / Lukas, Jiri; Altmeyer, Matthias.
In: E M B O Reports, Vol. 16, No. 11, 2015, p. 1413-1414.Research output: Contribution to journal › Comment/debate › Research
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TY - JOUR
T1 - A lncRNA to repair DNA
AU - Lukas, Jiri
AU - Altmeyer, Matthias
N1 - © 2015 The Authors.
PY - 2015
Y1 - 2015
N2 - Long non-coding RNAs (lncRNAs) have emerged as regulators of various biological processes, but to which extent lncRNAs play a role in genome integrity maintenance is not well understood. In this issue of EMBO Reports, Sharma et al [1] identify the DNA damage-induced lncRNA DDSR1 as an integral player of the DNA damage response (DDR). DDSR1 has both an early role by modulating repair pathway choices, and a later function when it regulates gene expression. Sharma et al [1] thus uncover a dual role for a hitherto uncharacterized lncRNA during the cellular response to DNA damage.
AB - Long non-coding RNAs (lncRNAs) have emerged as regulators of various biological processes, but to which extent lncRNAs play a role in genome integrity maintenance is not well understood. In this issue of EMBO Reports, Sharma et al [1] identify the DNA damage-induced lncRNA DDSR1 as an integral player of the DNA damage response (DDR). DDSR1 has both an early role by modulating repair pathway choices, and a later function when it regulates gene expression. Sharma et al [1] thus uncover a dual role for a hitherto uncharacterized lncRNA during the cellular response to DNA damage.
KW - BRCA1 Protein
KW - DNA Damage
KW - Homologous Recombination
KW - Humans
KW - RNA, Long Noncoding
KW - Comment
KW - Journal Article
U2 - 10.15252/embr.201541309
DO - 10.15252/embr.201541309
M3 - Comment/debate
C2 - 26420434
VL - 16
SP - 1413
EP - 1414
JO - E M B O Reports
JF - E M B O Reports
SN - 1469-221X
IS - 11
ER -
ID: 176966343