A genome-wide association study of social trust in 33,882 Danish blood donors

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

A genome-wide association study of social trust in 33,882 Danish blood donors. / Sequeros, Celia Burgos; Hansen, Thomas Folkmann; Westergaard, David; Louloudis, Ioannis; Kalamajski, Sebastian; Röder, Timo; Rohde, Palle Duun; Schwinn, Michael; Clemmensen, Line Harder; Didriksen, Maria; Nyegaard, Mette; Hjalgrim, Henrik; Nielsen, Kaspar René; Bruun, Mie Topholm; Ostrowski, Sisse Rye; Erikstrup, Christian; Mikkelsen, Susan; Sørensen, Erik; Pedersen, Ole Birger Vestager; Brunak, Søren; Banasik, Karina; Giordano, Giuseppe Nicola; DBDS Genomic Consortium.

In: Scientific Reports, Vol. 14, 1402, 2024.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sequeros, CB, Hansen, TF, Westergaard, D, Louloudis, I, Kalamajski, S, Röder, T, Rohde, PD, Schwinn, M, Clemmensen, LH, Didriksen, M, Nyegaard, M, Hjalgrim, H, Nielsen, KR, Bruun, MT, Ostrowski, SR, Erikstrup, C, Mikkelsen, S, Sørensen, E, Pedersen, OBV, Brunak, S, Banasik, K, Giordano, GN & DBDS Genomic Consortium 2024, 'A genome-wide association study of social trust in 33,882 Danish blood donors', Scientific Reports, vol. 14, 1402. https://doi.org/10.1038/s41598-024-51636-0

APA

Sequeros, C. B., Hansen, T. F., Westergaard, D., Louloudis, I., Kalamajski, S., Röder, T., Rohde, P. D., Schwinn, M., Clemmensen, L. H., Didriksen, M., Nyegaard, M., Hjalgrim, H., Nielsen, K. R., Bruun, M. T., Ostrowski, S. R., Erikstrup, C., Mikkelsen, S., Sørensen, E., Pedersen, O. B. V., ... DBDS Genomic Consortium (2024). A genome-wide association study of social trust in 33,882 Danish blood donors. Scientific Reports, 14, [1402]. https://doi.org/10.1038/s41598-024-51636-0

Vancouver

Sequeros CB, Hansen TF, Westergaard D, Louloudis I, Kalamajski S, Röder T et al. A genome-wide association study of social trust in 33,882 Danish blood donors. Scientific Reports. 2024;14. 1402. https://doi.org/10.1038/s41598-024-51636-0

Author

Sequeros, Celia Burgos ; Hansen, Thomas Folkmann ; Westergaard, David ; Louloudis, Ioannis ; Kalamajski, Sebastian ; Röder, Timo ; Rohde, Palle Duun ; Schwinn, Michael ; Clemmensen, Line Harder ; Didriksen, Maria ; Nyegaard, Mette ; Hjalgrim, Henrik ; Nielsen, Kaspar René ; Bruun, Mie Topholm ; Ostrowski, Sisse Rye ; Erikstrup, Christian ; Mikkelsen, Susan ; Sørensen, Erik ; Pedersen, Ole Birger Vestager ; Brunak, Søren ; Banasik, Karina ; Giordano, Giuseppe Nicola ; DBDS Genomic Consortium. / A genome-wide association study of social trust in 33,882 Danish blood donors. In: Scientific Reports. 2024 ; Vol. 14.

Bibtex

@article{51141d7cacf1466da3c93fd35c1516d7,
title = "A genome-wide association study of social trust in 33,882 Danish blood donors",
abstract = "Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brain-related phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent meta-analysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer region. Overall, our work confirms that social trust is heritable, and provides an initial look into the genetic factors that influence it.",
keywords = "Humans, Genome-Wide Association Study, Blood Donors, Trust, Phenotype, Denmark, Polymorphism, Single Nucleotide, Genetic Predisposition to Disease",
author = "Sequeros, {Celia Burgos} and Hansen, {Thomas Folkmann} and David Westergaard and Ioannis Louloudis and Sebastian Kalamajski and Timo R{\"o}der and Rohde, {Palle Duun} and Michael Schwinn and Clemmensen, {Line Harder} and Maria Didriksen and Mette Nyegaard and Henrik Hjalgrim and Nielsen, {Kaspar Ren{\'e}} and Bruun, {Mie Topholm} and Ostrowski, {Sisse Rye} and Christian Erikstrup and Susan Mikkelsen and Erik S{\o}rensen and Pedersen, {Ole Birger Vestager} and S{\o}ren Brunak and Karina Banasik and Giordano, {Giuseppe Nicola} and {DBDS Genomic Consortium}",
note = "{\textcopyright} 2024. The Author(s).",
year = "2024",
doi = "10.1038/s41598-024-51636-0",
language = "English",
volume = "14",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - A genome-wide association study of social trust in 33,882 Danish blood donors

AU - Sequeros, Celia Burgos

AU - Hansen, Thomas Folkmann

AU - Westergaard, David

AU - Louloudis, Ioannis

AU - Kalamajski, Sebastian

AU - Röder, Timo

AU - Rohde, Palle Duun

AU - Schwinn, Michael

AU - Clemmensen, Line Harder

AU - Didriksen, Maria

AU - Nyegaard, Mette

AU - Hjalgrim, Henrik

AU - Nielsen, Kaspar René

AU - Bruun, Mie Topholm

AU - Ostrowski, Sisse Rye

AU - Erikstrup, Christian

AU - Mikkelsen, Susan

AU - Sørensen, Erik

AU - Pedersen, Ole Birger Vestager

AU - Brunak, Søren

AU - Banasik, Karina

AU - Giordano, Giuseppe Nicola

AU - DBDS Genomic Consortium

N1 - © 2024. The Author(s).

PY - 2024

Y1 - 2024

N2 - Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brain-related phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent meta-analysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer region. Overall, our work confirms that social trust is heritable, and provides an initial look into the genetic factors that influence it.

AB - Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brain-related phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent meta-analysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer region. Overall, our work confirms that social trust is heritable, and provides an initial look into the genetic factors that influence it.

KW - Humans

KW - Genome-Wide Association Study

KW - Blood Donors

KW - Trust

KW - Phenotype

KW - Denmark

KW - Polymorphism, Single Nucleotide

KW - Genetic Predisposition to Disease

U2 - 10.1038/s41598-024-51636-0

DO - 10.1038/s41598-024-51636-0

M3 - Journal article

C2 - 38228779

VL - 14

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 1402

ER -

ID: 380416813