Søren Brunak
Professor
Brunak Group
Blegdamsvej 3B
2200 København N
- Published
Genetic variants associated with syncope implicate neural and autonomic processes
Aegisdottir, H. M., Thorolfsdottir, R. B., Sveinbjornsson, G., Stefansson, O. A., Gunnarsson, B., Tragante, V., Thorleifsson, G., Stefansdottir, L., Thorgeirsson, T. E., Ferkingstad, E., Sulem, P., Norddahl, G., Rutsdottir, G., Banasik, K., Christensen, A. H., Mikkelsen, C., Pedersen, O. B., Brunak, S., Bruun, M. T., Erikstrup, C. & 26 others, , 2023, In: European Heart Journal. 44, 12, p. 1070–1080 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models: [with Author Correction]
Allesøe, R. L., Lundgaard, A. T., Hernández Medina, R., Aguayo-Orozco, A., Johansen, J., Nissen, J. N., Brorsson, C., Mazzoni, G., Niu, L., Biel, J. H., Brasas, V., Webel, H., Benros, M. E., Pedersen, A. G., Chmura, P. J., Jacobsen, U. P., Mari, A., Koivula, R., Mahajan, A., Vinuela, A. & 31 others, , 2023, In: Nature Biotechnology. 41, 3, p. 399–408 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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An Increase in Specialist Treatment for Onychomycosis: An Unexplained Tendency. A Retrospective Study of Patients Treated for Onychomycosis in Danish Hospitals from 1994 to 2018
Andersen, P. L., Jørgensen, Isabella Friis, Saunte, Ditte Marie, Jemec, Gregor, Pedersen, Ole Birger Vesterager & Brunak, Søren, 2023, In: Journal of Fungi. 9, 1, 7 p., 33.Research output: Contribution to journal › Journal article › Research › peer-review
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DanMAC5: a browser of aggregated sequence variants from 8,671 whole genome sequenced Danish individuals
Banasik, K., Møller, P. L., Techlo, T. R., Holm, P. C., Walters, G. B., Ingason, A., Rosengren, A., Rohde, P. D., Kogelman, L. J. A., Westergaard, D., Siggaard, T., Chmura, P. J., Chalmer, M. A., Magnússon, Ó., Þórisson, G., Stefánsson, H., Guðbjartsson, D. F., Stefánsson, K., Olesen, J., Winther, S. & 5 others, , 2023, In: BMC Genomic Data. 24, 1, 4 p., 30.Research output: Contribution to journal › Comment/debate › Research › peer-review
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Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth
Beaumont, R. N., Flatley, C., Vaudel, M., Wu, X., Chen, J., Moen, G. H., Skotte, L., Helgeland, Ø., Solé-Navais, P., Banasik, K., Albiñana, C., Ronkainen, J., Fadista, J., Stinson, S. E., Trajanoska, K., Wang, C. A., Westergaard, D., Srinivasan, S., Sánchez-Soriano, C., Bilbao, J. R. & 68 others, , 2023, In: Nature Genetics. 55, 11, p. 1807-1819 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rare variants with large effects provide functional insights into the pathology of migraine subtypes, with and without aura
Bjornsdottir, G., Chalmer, M. A., Stefansdottir, L., Skuladottir, A. T., Einarsson, G., Andresdottir, M., Beyter, D., Ferkingstad, E., Gretarsdottir, S., Halldorsson, B. V., Halldorsson, G. H., Helgadottir, A., Helgason, H., Hjorleifsson Eldjarn, G., Jonasdottir, A., Jonasdottir, A., Jonsdottir, I., Knowlton, K. U., Nadauld, L. D., Lund, S. H. & 30 others, , 2023, In: Nature Genetics. 55, 11, p. 1843-1853Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits
Brown, A. A., Fernandez-Tajes, J. J., Hong, M. G., Brorsson, C. A., Koivula, R. W., Davtian, D., Dupuis, T., Sartori, A., Michalettou, T. D., Forgie, I. M., Adam, J., Allin, K. H., Caiazzo, R., Cederberg, H., De Masi, F., Elders, P. J. M., Giordano, G. N., Haid, M., Hansen, T., Hansen, T. H. & 134 others, , 2023, In: Nature Communications. 14, 17 p., 5062.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Associations of ABO and Rhesus D blood groups with phenome-wide disease incidence: A 41-year retrospective cohort study of 482,914 patients
Bruun-Rasmussen, P., Dziegiel, Morten Hanefeld, Banasik, Karina, Johansson, Pär Ingemar & Brunak, Søren, 2023, In: eLife. 12, 17 p., e83116.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Population-Based Characterization of Menstrual Migraine and Proposed Diagnostic Criteria
Chalmer, M. A., Kogelman, L. J. A., Ullum, H., Sørensen, E., Didriksen, Maria, Mikkelsen, S., Dinh, K. M., Brodersen, T., Nielsen, K. R., Bruun, M. T., Banasik, Karina, Brunak, Søren, Erikstrup, C., Pedersen, Ole Birger Vesterager, Ostrowski, Sisse Rye, Olesen, Jes & Hansen, Thomas Folkmann, 2023, In: JAMA network open. 6, 5, 12 p., e2313235.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cohort Profile: The Danish Blood Donor Study
Erikstrup, C., Sørensen, E., Nielsen, K. R., Bruun, M. T., Petersen, M. S., Rostgaard, K., Thørner, L. W., Larsen, M., Mikkelsen, S., Dinh, K. M., Schwinn, M., Rigas, A. S., Didriksen, M., Dowsett, J., von Stemann, J. H., Brodersen, T., Paulsen, I. W., Hindhede, L., Sækmose, S. G., Kaspersen, K. A. & 10 others, , 2023, In: International Journal of Epidemiology. 52, 3, p. e162-e171 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genome-wide meta-analysis identifies 93 risk loci and enables risk prediction equivalent to monogenic forms of venous thromboembolism
Ghouse, J., Tragante, V., Ahlberg, G., Rand, S. A., Jespersen, J. B., Leinøe, E. B., Vissing, C. R., Trudsø, L., Jonsdottir, I., Banasik, K., Brunak, S., Ostrowski, S. R., Pedersen, O. B., Sørensen, E., Erikstrup, C., Bruun, M. T., Nielsen, K. R., Køber, L., Christensen, A. H., Iversen, K. & 16 others, , 2023, In: Nature Genetics. 55, p. 399-409 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genome-wide association meta-analysis of knee and hip osteoarthritis uncovers genetic differences between patients treated with joint replacement and patients without joint replacement
Henkel, C., Styrkársdóttir, U., Thorleifsson, G., Stefánsdóttir, L., Björnsdóttir, G., Banasik, K., Brunak, S., Erikstrup, C., Dinh, K. M., Hansen, T. F., Nielsen, K. R., Bruun, M. T., Dowsett, J., Brodersen, T., Thorgeirsson, T. E., Gromov, K., Boesen, M. P., Ullum, H., Ostrowski, S. R., Pedersen, O. B. & 3 others, , 2023, In: Annals of the Rheumatic Diseases. 82, p. 384-392Research output: Contribution to journal › Journal article › Research › peer-review
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Pancreatic cancer symptom trajectories from Danish registry data and free text in electronic health records
Hjaltelin, Jessica Xin, Novitski, Sif Ingibergsdóttir, Jørgensen, Isabella Friis, Siggaard, T., Vulpius, S. A., Westergaard, David, Johansen, Julia Sidenius, Chen, I. M., Jensen, Lars Juhl & Brunak, Søren, 2023, In: eLife. 12, 15 p., e84919.Research output: Contribution to journal › Journal article › Research › peer-review
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Visualising disease trajectories from population-wide data
Hjaltelin, Jessica Xin, Currant, H., Jørgensen, Isabella Friis & Brunak, Søren, 2023, In: Frontiers in Bioinformatics. 3, 5 p., 1112113.Research output: Contribution to journal › Editorial › Research › peer-review
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Plasma YKL-40 is associated with prognosis in patients with metastatic pancreatic cancer receiving immune checkpoint inhibitors in combination with radiotherapy
Johansen, A. Z., Novitski, Sif Ingibergsdóttir, Hjaltelin, Jessica Xin, Theile, S., Boisen, M. K., Brunak, Søren, Madsen, Daniel Hargbøl, Nielsen, Dorte Lisbet & Chen, I. M., 2023, In: Frontiers in Immunology. 14, 10 p., 1228907.Research output: Contribution to journal › Journal article › Research › peer-review
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Precision medicine in complex diseases - Molecular subgrouping for improved prediction and treatment stratification
Johansson, Å., Andreassen, O. A., Brunak, Søren, Franks, P. W., Hedman, H., Loos, Ruth, Meder, B., Melén, E., Wheelock, C. E. & Jacobsson, B., 2023, In: Journal of Internal Medicine. 294, 4, p. 378-396 19 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
A second update on mapping the human genetic architecture of COVID-19
Kanai, M., Andrews, S., Cordioli, M., Stevens, C., Neale, B. M., Daly, M., Ganna, A., Pathak, G. A., Ellinghaus, D., Banasik, K., Brunak, S., Pedersen, O. B., Westergaard, D., Sequeros, C. B., Nissen, J., Feldt-Rasmussen, U., Grønbæk, K., Ostrowski, S. R., Guindo-Martinez, M., Garcia, S. M. & 70 others, , 2023, In: Nature. 621, 7977, p. E7-E26 23 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Drug dosage modifications in 24 million in-patient prescriptions covering eight years: A Danish population-wide study of polypharmacy
Leal Rodríguez, C., Haue, Amalie Dahl, Mazzoni, G., Eriksson, R., Hernansanz Biel, J., Cantwell, Lisa, Westergaard, David, Belling, K. G. & Brunak, Søren, 2023, In: PLOS Digital Health. 2, 9, 27 p., e0000336.Research output: Contribution to journal › Journal article › Research › peer-review
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BALDR: A Web-based platform for informed comparison and prioritization of biomarker candidates for type 2 diabetes mellitus
Lundgaard, Agnete Troen, Burdet, F., Siggaard, T., Westergaard, David, Vagiaki, D., Cantwell, Lisa, Röder, T., Vistisen, D., Sparsø, T., Giordano, G. N., Ibberson, M., Banasik, Karina & Brunak, Søren, 2023, In: PLOS Computational Biology. 19, 8, 13 p., e1011403.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic prediction of 33 blood group phenotypes using an existing genotype dataset
Moslemi, C., Sækmose, S. G., Larsen, R., Bay, J. T., Brodersen, T., Didriksen, M., Hjalgrim, H., Banasik, K., Nielsen, K. R., Bruun, M. T., Dowsett, J., Dinh, K. M., Mikkelsen, S., Mikkelsen, C., Hansen, T. F., Ullum, H., Erikstrup, C., Brunak, S., Krogfelt, K. A., Storry, J. R. & 3 others, , 2023, In: Transfusion. 63, 12, p. 2297-2310 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes distinguishes markers of disease and C-peptide trajectory
Moulder, R., Välikangas, T., Hirvonen, M. K., Suomi, T., Brorsson, C. A., Lietzén, N., Bruggraber, S. F. A., Overbergh, L., Dunger, D. B., Peakman, M., Chmura, Piotr Jaroslaw, Brunak, Søren, Schulte, A. M., Mathieu, C., Knip, M., Elo, L. L., Lahesmaa, R. & on behalf of the INNODIA consortium, O. B. O. T. I. C., 2023, In: Diabetologia. 66, p. 1983-1996Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Population-wide analysis of hospital laboratory tests to assess seasonal variation and temporal reference interval modification
Muse, V. P., Aguayo-Orozco, A., Balaganeshan, Sedrah Butt & Brunak, Søren, 2023, In: Patterns. 4, 8, 14 p., 100778.Research output: Contribution to journal › Journal article › Research › peer-review
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An atlas of genetic determinants of forearm fracture
Nethander, M., Movérare-Skrtic, S., Kämpe, A., Coward, E., Reimann, E., Grahnemo, L., Borbély, É., Helyes, Z., Funck-Brentano, T., Cohen-Solal, M., Tuukkanen, J., Koskela, A., Wu, J., Li, L., Lu, T., Gabrielsen, M. E., Mägi, R., Hoff, M., Lerner, U. H., Henning, P. & 15 others, , 2023, In: Nature Genetics. 55, 11, p. 1820-1830 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethality
Oddsson, A., Sulem, P., Sveinbjornsson, G., Arnadottir, G. A., Steinthorsdottir, V., Halldorsson, G. H., Atlason, B. A., Oskarsson, G. R., Helgason, H., Nielsen, H. S., Westergaard, D., Karjalainen, J. M., Katrinardottir, H., Fridriksdottir, R., Jensson, B. O., Tragante, V., Ferkingstad, E., Jonsson, H., Gudjonsson, S. A., Beyter, D. & 31 others, , 2023, In: Nature Communications. 14, 15 p., 3453.Research output: Contribution to journal › Journal article › Research › peer-review
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A unidirectional mapping of ICD-8 to ICD-10 codes, for harmonized longitudinal analysis of diseases
Pedersen, M. K., Eriksson, R., Reguant, R., Collin, C., Pedersen, H. K., Sørup, Freja Karuna Hemmingsen, Simon, C., Birch, A. M., Larsen, Michael, Nielsen, A. P., Belling, K. & Brunak, Søren, 2023, In: European Journal of Epidemiology. 38, p. 1043–1052 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A deep learning algorithm to predict risk of pancreatic cancer from disease trajectories
Placido, D., Yuan, B., Hjaltelin, J. X., Zheng, C., Haue, A. D., Chmura, P. J., Yuan, C., Kim, J., Umeton, R., Antell, G., Chowdhury, A., Franz, A., Brais, L., Andrews, E., Marks, D. S., Regev, A., Ayandeh, S., Brophy, M. T., Do, N. V., Kraft, P. & 5 others, , 2023, In: Nature Medicine. 29, p. 1113-1122Research output: Contribution to journal › Journal article › Research › peer-review
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Development of a dynamic prediction model for unplanned ICU admission and mortality in hospitalized patients
Placido, Davide, Thorsen-Meyer, H., Kaas-Hansen, Benjamin Skov, Reguant, R. & Brunak, Søren, 2023, In: PLOS Digital Health. 2, 6, 18 p., e0000116.Research output: Contribution to journal › Journal article › Research › peer-review
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The small and large intestine contain related mesenchymal subsets that derive from embryonic Gli1+ precursors
Pærregaard, S. I., Wulff, L., Schussek, S., Niss, K., Mörbe, U., Jendholm, J., Wendland, K., Andrusaite, A. T., Brulois, K. F., Nibbs, R. J. B., Sitnik, K., Mowat, A. M. I., Butcher, E. C., Brunak, Søren & Agace, W. W., 2023, In: Nature Communications. 14, 1, 2307.Research output: Contribution to journal › Journal article › Research › peer-review
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Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target
Roychowdhury, T., Klarin, D., Levin, M. G., Spin, J. M., Rhee, Y. H., Deng, A., Headley, C. A., Tsao, N. L., Gellatly, C., Zuber, V., Shen, F., Hornsby, W. E., Laursen, I. H., Verma, S. S., Locke, A. E., Einarsson, G., Thorleifsson, G., Graham, S. E., Dikilitas, O., Pattee, J. W. & 74 others, , 2023, In: Nature Genetics. 55, p. 1831–1842 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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eTRANSAFE: data science to empower translational safety assessment
Sanz, F., Pognan, F., Steger-Hartmann, T., Díaz, C., Asakura, S., Amberg, A., Bécourt-Lhote, N., Blomberg, N., Bosc, N., Briggs, K., Bringezu, F., Brulle-Wohlhueter, C., Brunak, S., Bueters, R., Callegaro, G., Capella-Gutierrez, S., Centeno, E., Corvi, J., Cronin, M. T. D., Drew, P. & 41 others, , 2023, In: Nature Reviews Drug Discovery. 22, 8, p. 605-606 2 p.Research output: Contribution to journal › Comment/debate › Research
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Deep integrative models for large-scale human genomics
Sigurdsson, Arnór Ingi, Louloudis, Ioannis, Banasik, Karina, Westergaard, David, Winther, Ole, Lund, O., Ostrowski, Sisse Rye, Erikstrup, C., Pedersen, Ole Birger Vesterager, Nyegaard, Mette, Brunak, Søren, Vilhjálmsson, B. & Rasmussen, Simon, 2023, In: Nucleic Acids Symposium Series. 51, 12, 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification of biomarkers for glycaemic deterioration in type 2 diabetes
Slieker, R. C., Donnelly, L. A., Akalestou, E., Lopez-Noriega, L., Melhem, R., Güneş, A., Abou Azar, F., Efanov, A., Georgiadou, E., Muniangi-Muhitu, H., Sheikh, M., Giordano, G. N., Åkerlund, M., Ahlqvist, E., Ali, A., Banasik, K., Brunak, S., Barovic, M., Bouland, G. A., Burdet, F. & 46 others, , 2023, In: Nature Communications. 14, 18 p., 2533.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Complex effects of sequence variants on lipid levels and coronary artery disease
Snaebjarnarson, A. S., Helgadottir, A., Arnadottir, G. A., Ivarsdottir, E. V., Thorleifsson, G., Ferkingstad, E., Einarsson, G., Sveinbjornsson, G., Thorgeirsson, T. E., Ulfarsson, M. O., Halldorsson, B. V., Olafsson, I., Erikstrup, C., Pedersen, O. B., Nyegaard, M., Bruun, M. T., Ullum, H., Brunak, S., Iversen, K. K., Christensen, A. H. & 14 others, , 2023, In: Cell. 186, 19, p. 4085-4099.e15Research output: Contribution to journal › Journal article › Research › peer-review
- E-pub ahead of print
Obesity variants in the GIPR gene do not associate with risk of fracture or bone mineral density
Styrkarsdottir, U., Tragante, V., Stefansdottir, L., Thorleifsson, G., Oddsson, A., Sørensen, E., Erikstrup, C., Schwarz, Peter, Jørgensen, Henrik Løvendahl, Lauritzen, Jes Bruun, Brunak, Søren, Knowlton, K. U., Nadauld, L. D., Ullum, H., Pedersen, Ole Birger Vesterager, Ostrowski, Sisse Rye, Holm, H., Gudbjartsson, D. F., Sulem, P. & Stefansson, K., 2023, (E-pub ahead of print) In: Journal of Clinical Endocrinology and Metabolism.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Gene expression signature predicts rate of type 1 diabetes progression
Suomi, T., Starskaia, I., Kalim, U. U., Rasool, O., Jaakkola, M. K., Grönroos, T., Välikangas, T., Brorsson, C., Mazzoni, G., Bruggraber, S., Overbergh, L., Dunger, D., Peakman, M., Chmura, P., Brunak, S., Schulte, A. M., Mathieu, C., Knip, M., Lahesmaa, R., Elo, L. L. & 4 others, , 2023, In: EBioMedicine. 92, 18 p., 104625.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Abnormal serum levels of magnesium, phosphate, and zinc in ICU patients—Characteristics, management, and outcomes: The WhyTrace cohort study
Vesterlund, G. K., Thorsen-Meyer, H. C., Møller, Morten Hylander, Brunak, Søren, Strøm, T., Perner, Anders & Kaas-Hansen, Benjamin Skov, 2023, In: Acta Anaesthesiologica Scandinavica. 67, 7, p. 925-935 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pregnancy-Associated Bleeding and Genetics: Five Sequence Variants in the Myometrium and Progesterone Signaling Pathway are associated with postpartum hemorrhage
Westergaard, D., Steinthorsdottir, V., Stefansdottir, L., Rohde, P. D., Wu, X., Geller, F., Tyrmi, J., Havulinna, A. S., Navais, P. S., Flatley, C., Ostrowski, S. R., Pedersen, O. B., Erikstrup, C., Sørensen, E., Mikkelsen, C., Brun, M. T., Jensen, B. A., Brodersen, T., Ullum, H., Magnus, P. & 8 others, , 2023, medRxiv, 51 p. (medRxiv).Research output: Working paper › Preprint › Research
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The promise of digital healthcare technologies
Yeung, A. W. K., Torkamani, A., Butte, A. J., Glicksberg, B. S., Schuller, B., Rodriguez, B., Ting, D. S. W., Bates, D., Schaden, E., Peng, H., Willschke, H., van der Laak, J., Car, J., Rahimi, K., Celi, L. A., Banach, M., Kletecka-Pulker, M., Kimberger, O., Eils, R., Islam, S. M. S. & 5 others, , 2023, In: Frontiers in Public Health. 11, 12 p., 1196596.Research output: Contribution to journal › Review › Research › peer-review
ID: 12895347
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Identification of odorant-receptor interactions by global mapping of the human odorome
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Porcine transcriptome analysis based on 97 non-normalized cDNA libraries and assembly of 1,021,891 expressed sequence tags
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A human gut microbial gene catalogue established by metagenomic sequencing
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