Mesoscale organization of the chromatin fiber

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Mesoscale organization of the chromatin fiber. / Krietenstein, Nils; Rando, Oliver J.

In: Current Opinion in Genetics & Development, Vol. 61, 04.2020, p. 32-36.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Krietenstein, N & Rando, OJ 2020, 'Mesoscale organization of the chromatin fiber', Current Opinion in Genetics & Development, vol. 61, pp. 32-36. https://doi.org/10.1016/j.gde.2020.02.022

APA

Krietenstein, N., & Rando, O. J. (2020). Mesoscale organization of the chromatin fiber. Current Opinion in Genetics & Development, 61, 32-36. https://doi.org/10.1016/j.gde.2020.02.022

Vancouver

Krietenstein N, Rando OJ. Mesoscale organization of the chromatin fiber. Current Opinion in Genetics & Development. 2020 Apr;61:32-36. https://doi.org/10.1016/j.gde.2020.02.022

Author

Krietenstein, Nils ; Rando, Oliver J. / Mesoscale organization of the chromatin fiber. In: Current Opinion in Genetics & Development. 2020 ; Vol. 61. pp. 32-36.

Bibtex

@article{5aad1d70951c40759f59a94ee5a29442,
title = "Mesoscale organization of the chromatin fiber",
abstract = "The proper organization of the physical genome is essential to facilitate DNA-templated processes from transcription to replication to DNA repair. Genome-wide studies over the past two decades have provided us with a detailed understanding of the positions and modification states of nucleosomes across the genomes of many organisms, as well as an increasingly mature understanding of chromosome organization at the kilobase to megabase scale. Here, we explore chromatin organization at intermediate scales of ∼2-10 nucleosomes, from early views supporting a secondary structural element known as the 30nm fiber to more recent 'sea of nucleosomes' models.",
keywords = "Animals, Chromatin/genetics, Chromosomes/genetics, DNA/genetics, DNA Replication/genetics, Genome/genetics, Humans, Nucleosomes/genetics, Transcription, Genetic/genetics",
author = "Nils Krietenstein and Rando, {Oliver J}",
note = "Copyright {\textcopyright} 2020 Elsevier Ltd. All rights reserved.",
year = "2020",
month = apr,
doi = "10.1016/j.gde.2020.02.022",
language = "English",
volume = "61",
pages = "32--36",
journal = "Current Opinion in Genetics & Development",
issn = "0959-437X",
publisher = "Elsevier Ltd. * Current Opinion Journals",

}

RIS

TY - JOUR

T1 - Mesoscale organization of the chromatin fiber

AU - Krietenstein, Nils

AU - Rando, Oliver J

N1 - Copyright © 2020 Elsevier Ltd. All rights reserved.

PY - 2020/4

Y1 - 2020/4

N2 - The proper organization of the physical genome is essential to facilitate DNA-templated processes from transcription to replication to DNA repair. Genome-wide studies over the past two decades have provided us with a detailed understanding of the positions and modification states of nucleosomes across the genomes of many organisms, as well as an increasingly mature understanding of chromosome organization at the kilobase to megabase scale. Here, we explore chromatin organization at intermediate scales of ∼2-10 nucleosomes, from early views supporting a secondary structural element known as the 30nm fiber to more recent 'sea of nucleosomes' models.

AB - The proper organization of the physical genome is essential to facilitate DNA-templated processes from transcription to replication to DNA repair. Genome-wide studies over the past two decades have provided us with a detailed understanding of the positions and modification states of nucleosomes across the genomes of many organisms, as well as an increasingly mature understanding of chromosome organization at the kilobase to megabase scale. Here, we explore chromatin organization at intermediate scales of ∼2-10 nucleosomes, from early views supporting a secondary structural element known as the 30nm fiber to more recent 'sea of nucleosomes' models.

KW - Animals

KW - Chromatin/genetics

KW - Chromosomes/genetics

KW - DNA/genetics

KW - DNA Replication/genetics

KW - Genome/genetics

KW - Humans

KW - Nucleosomes/genetics

KW - Transcription, Genetic/genetics

U2 - 10.1016/j.gde.2020.02.022

DO - 10.1016/j.gde.2020.02.022

M3 - Review

C2 - 32305817

VL - 61

SP - 32

EP - 36

JO - Current Opinion in Genetics & Development

JF - Current Opinion in Genetics & Development

SN - 0959-437X

ER -

ID: 301925103