Protein annotation in the era of personal genomics
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Protein annotation in the era of personal genomics. / Blicher, Thomas; Gupta, Ramneek; Wesolowska, Agata; Jensen, Lars Juhl; Brunak, Søren.
In: Current Opinion in Structural Biology, Vol. 20, No. 3, 01.06.2010, p. 335-41.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Protein annotation in the era of personal genomics
AU - Blicher, Thomas
AU - Gupta, Ramneek
AU - Wesolowska, Agata
AU - Jensen, Lars Juhl
AU - Brunak, Søren
N1 - Copyright 2010 Elsevier Ltd. All rights reserved.
PY - 2010/6/1
Y1 - 2010/6/1
N2 - Protein annotation provides a condensed and systematic view on the function of individual proteins. It has traditionally dealt with sorting proteins into functional categories, which for example has proven to be successful for the comparison of different species. However, if we are to understand the differences between many individuals of the same species-humans in particular - the focus needs be on the functional impact of individual residue variation. To fulfil the promises of personal genomics, we need to start asking not only what is in a genome but also how millions of small differences between individual genomes affect protein function and in turn human health.
AB - Protein annotation provides a condensed and systematic view on the function of individual proteins. It has traditionally dealt with sorting proteins into functional categories, which for example has proven to be successful for the comparison of different species. However, if we are to understand the differences between many individuals of the same species-humans in particular - the focus needs be on the functional impact of individual residue variation. To fulfil the promises of personal genomics, we need to start asking not only what is in a genome but also how millions of small differences between individual genomes affect protein function and in turn human health.
KW - Amino Acid Motifs
KW - Amino Acid Sequence
KW - Animals
KW - Genome, Human
KW - Genomics
KW - Humans
KW - Molecular Sequence Data
KW - Proteins
U2 - 10.1016/j.sbi.2010.03.008
DO - 10.1016/j.sbi.2010.03.008
M3 - Journal article
C2 - 20403684
VL - 20
SP - 335
EP - 341
JO - Current Opinion in Structural Biology
JF - Current Opinion in Structural Biology
SN - 0959-440X
IS - 3
ER -
ID: 33748716