A scored human protein-protein interaction network to catalyze genomic interpretation
Publikation: Bidrag til tidsskrift › Letter › Forskning › fagfællebedømt
Genome-scale human protein-protein interaction networks are critical to understanding cell biology and interpreting genomic data, but challenging to produce experimentally. Through data integration and quality control, we provide a scored human protein-protein interaction network (InWeb_InBioMap, or InWeb_IM) with severalfold more interactions (>500,000) and better functional biological relevance than comparable resources. We illustrate that InWeb_InBioMap enables functional interpretation of >4,700 cancer genomes and genes involved in autism.
Originalsprog | Engelsk |
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Tidsskrift | Nature Methods |
Vol/bind | 14 |
Udgave nummer | 1 |
Sider (fra-til) | 61–64 |
ISSN | 1548-7091 |
DOI | |
Status | Udgivet - jan. 2017 |
ID: 169733207