Pope Lloyd Moseley
Disease Systems Biology Program
Blegdamsvej 3, 2200 København N
Pope Moseley is a lung and intensive care physician and translational sciences researcher. As an academic administrator, he served as the Senior Associate Dean for Research and Chair of the Department of Internal Medicine at the University of New Mexico College of Medicine then as Dean of the College of Medicine and Executive Vice Chancellor of the Universith of Arkansas for Medical Sciences. While at the University of New Mexico, he was principal investigator of the NIH P20 Environmental Health Sciences Center and Associate Director of the NIH U54 Clinical and Translational Research Center.
For more than 25 years, he has led an NIH funded translational research program focused on the role of the cellular heat shock response in adaptation to exercise stress. Using both cellular systems and studies in human subjects, his research group identified gut injury and the loss of epithelial barrier integrity as early and pivotal events in the pathogenesis of heat sttoke. They also defined the role of heat shock proteins in modulating inflammation using both exercise and glutamine supplementation to augment the heat shock response and HSF-1 knock down in exercising humans to block the heat shock response. These data help explain the anti-inflammatory and health benefits of exercise. His group developed a series of novel gene transfer vectors which allowed them to demonstrate the requirement of HSPs in viral replication and the regulatory role of both Hsp70 and HSF-1 in controlling autophagy.
At CPR, Dr. Moseley has contributed to the development of the NPR based disease trajectory project and clinical studies of the disease systems biology group.