Niels Mailand

Niels Mailand

professor, group leader

  • Mailand Group

    Blegdamsvej 3, 2200 København N, Bygning 6, Building: 06-3-10

    Phone: +45 35 32 50 23Mobile: +45 26 18 19 13

  1. 2020
  2. Published

    Multi-site SUMOylation restrains DNA polymerase η interactions with DNA damage sites

    Guerillon, Claire Aline, Smedegaard, S., Hendriks, Ivo Alexander, Nielsen, Michael Lund & Mailand, Niels, 2020, In : Journal of Biological Chemistry. 295, p. 8350-8362

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. 2019
  4. Published

    An unorthodox partnership in DNA repair pathway choice

    Typas, Dimitris & Mailand, Niels, 2019, In : EMBO Reports. 20, 11, e49105.

    Research output: Contribution to journalEditorialResearchpeer-review

  5. Published

    GIGYF1/2-Driven Cooperation between ZNF598 and TTP in Posttranscriptional Regulation of Inflammatory Signaling

    Tollenaere, M. A. X., Tiedje, C., Rasmussen, S., Nielsen, J. C., Vind, Anna Constance, Blasius, Melanie, Batth, Tanveer Singh, Mailand, Niels, Olsen, Jesper Velgaard, Gaestel, M. & Bekker-Jensen, Simon Holst, 2019, In : Cell Reports. 26, 13, p. 3511-3521.e4 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability

    Achuthankutty, D., Thakur, Roshan Singh, Haahr, Peter Thorlund, Hoffmann, Saskia, Drainas, A. P., Bizard, Anna Helene, Weischenfeldt, Joachim Lütken, Hickson, Ian David & Mailand, Niels, 2019, In : The Journal of Cell Biology. 218, 12, 11 p., 3943.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    SUMOylation promotes protective responses to DNA-protein crosslinks

    Borgermann, N., Ackermann, Leena, Schwertman, P., Hendriks, Ivo Alexander, Thijssen, K., Liu, Julio, Lans, H., Nielsen, Michael Lund & Mailand, Niels, 2019, In : E M B O Journal. 38, 17 p., e101496.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation

    Rabl, J., Bunker, R. D., Schenk, A. D., Cavadini, S., Gill, M. E., Abdulrahman, W., Andrés-Pons, A., Luijsterburg, M. S., Ibrahim, A. F. M., Branigan, E., Aguirre, J. D., Marceau, A. H., Guérillon, C., Bouwmeester, T., Hassiepen, U., Peters, A. H. F. M., Renatus, M., Gelman, L., Rubin, S. M., Mailand, Niels, van Attikum, H., Hay, R. T. & Thomä, N. H., 2019, In : Molecular Cell. 75, 3, p. 483-497.e9 25 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication

    Sonneville, R., Bhowmick, Rahul, Hoffmann, Saskia, Mailand, Niels, Hickson, Ian David & Labib, K., 2019, In : eLife. 8, 19 p., e48686.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    The p97-Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8

    Singh, A. N., Oehler, J., Torrecilla, I., Kilgas, S., Li, S., Vaz, B., Guerillon, C., Fielden, J., Esperanza Hernandez-Carralero, Cabrera, E., Tullis, I. D. C., Meerang, M., Barber, P. R., Freire, R., Parsons, J., Vojnovic, B., Kiltie, A. E., Mailand, Niels & Ramadan, K., 2019, In : EMBO Journal. 38, 25 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. 2018
  12. Published

    DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity

    Gupta, R., Somyajit, Kumar, Narita, Takeo, Maskey, E., Stanlie, A., Kremer, M., Typas, Dimitris, Lammers, M., Mailand, Niels, Nussenzweig, A., Lukas, Jiri & Choudhary, Chuna Ram, 2018, In : Cell. 173, 4, p. 972-988

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    ZUFSP Deubiquitylates K63-Linked Polyubiquitin Chains to Promote Genome Stability

    Haahr, Peter Thorlund, Borgermann, N., Guo, X., Typas, Dimitris, Achuthankutty, D., Hoffmann, Saskia, Shearer, Robert Francis, Sixma, T. K. & Mailand, Niels, 2018, In : Molecular Cell. 70, 1, p. 165-174

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage

    Borisova, M. E., Voigt, A., Tollenaere, M. A. X., Sahu, S. K., Juretschke, T., Kreim, N., Mailand, Niels, Choudhary, Chuna Ram, Bekker-Jensen, Simon Holst, Akutsu, M., Wagner, S. A. & Beli, P., 2018, In : Nature Communications. 9, p. 1-16 16 p., 1017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. 2017
  16. Published

    RADX interacts with single-stranded DNA to promote replication fork stability

    Schubert, Lisa, Ho, T., Hoffmann, Saskia, Haahr, Peter Thorlund, Guérillon, C. & Mailand, Niels, Nov 2017, In : EMBO Reports. 18, 11, p. 1991-2003 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. 2016
  18. Published

    SCAI promotes DNA double-strand break repair in distinct chromosomal contexts

    Hansen, R. K., Mund, Andreas, Poulsen, S. L., Sandoval, M., Klement, K., Tsouroula, K., Tollenaere, M. A. X., Räschle, M., Soria, R., Offermanns, S., Worzfeld, T., Grosse, R., Brandt, D. T., Rozell, B., Mann, Matthias, Cole, F., Soutoglou, E., Goodarzi, A. A., Daniel, J. A., Mailand, Niels & Bekker-Jensen, Simon Holst, 7 Nov 2016, In : Nature Cell Biology. 18, 12, p. 1357–1366

    Research output: Contribution to journalLetterResearchpeer-review

  19. Published

    Activation of the ATR kinase by the RPA-binding protein ETAA1

    Haahr, Peter Thorlund, Hoffmann, Saskia, Tollenaere, M. A. X., Ho, T., Toledo Lazaro, Luis Ignacio, Mann, Matthias, Bekker-Jensen, Simon Holst, Räschle, M. & Mailand, Niels, Nov 2016, In : Nature Cell Biology. 18, 11, p. 1196–1207

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex

    Saredi, G., Huang, H., Hammond, Colin, Alabert, C., Bekker-Jensen, Simon Holst, Forne, I., Reveron-Gomez, Nazaret, Foster, B. M., Mlejnkova, L., Bartke, T., Cejka, P., Mailand, Niels, Imhof, A., Patel, D. J. & Groth, Anja, 30 Jun 2016, In : Nature. 534, 7609, p. 714-8 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Writers, Readers, and Erasers of Histone Ubiquitylation in DNA Double-Strand Break Repair

    Smeenk, G. & Mailand, Niels, 28 Jun 2016, In : Frontiers in Genetics. 7, 14 p., 122.

    Research output: Contribution to journalReviewResearchpeer-review

  22. Published

    Structural Analysis of a Complex between Small Ubiquitin-like Modifier 1 (SUMO1) and the ZZ Domain of CREB-binding Protein (CBP/p300) Reveals a New Interaction Surface on SUMO

    Diehl, C., Akke, M., Bekker-Jensen, Simon Holst, Mailand, Niels, Streicher, W. & Wikström, M., 10 Jun 2016, In : Journal of Biological Chemistry. 291, 24, p. 12658-12672 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers

    Schwertman, P., Bekker-Jensen, Simon Holst & Mailand, Niels, Jun 2016, In : Nature Reviews. Molecular Cell Biology. 17, 6, p. 379-94 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress

    Hoffmann, Saskia, Smedegaard, S., Nakamura, Kyosuke, Mortuza, G. B., Räschle, M., Ibañez de Opakua, A., Oka, Y., Feng, Y., Blanco, F. J., Mann, Matthias, Montoya, Guillermo, Groth, Anja, Bekker-Jensen, Simon Holst & Mailand, Niels, 4 Jan 2016, In : The Journal of Cell Biology. 212, 1, p. 63-75

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. 2015
  26. Published

    p38- and MK2-dependent signalling promotes stress-induced centriolar satellite remodelling via 14-3-3-dependent sequestration of CEP131/AZI1

    Tollenaere, M. A. X., Villumsen, B. H., Blasius, M., Nielsen, J. C., Wagner, S. A., Bartek, J., Beli, P., Mailand, Niels & Bekker-Jensen, Simon Holst, 30 Nov 2015, In : Nature Communications. 6, p. 1-12 12 p., 10075.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage

    Thorslund, T., Ripplinger, A., Hoffmann, Saskia, Wild, T., Uckelmann, M., Villumsen, B., Narita, Takeo, Sixma, T. K., Choudhary, Chuna Ram, Bekker-Jensen, Simon Holst & Mailand, Niels, 19 Nov 2015, In : Nature. 527, 7578, p. 389-93 5 p.

    Research output: Contribution to journalLetterResearchpeer-review

  28. Published

    RNF138 joins the HR team

    Bekker-Jensen, Simon Holst & Mailand, Niels, Oct 2015, In : Nature Cell Biology. 17, 11, p. 1375-7 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    SUMO and ubiquitin-dependent XPC exchange drives nucleotide excision repair

    Van Cuijk, L., Van Belle, G. J., Turkyilmaz, Y., Poulsen, S. L., Janssens, R. C., Theil, A. F., Sabatella, M., Lans, H., Mailand, Niels, Houtsmuller, A. B., Vermeulen, W. & Marteijn, J. A., 7 Jul 2015, In : Nature Communications. 6, 10 p., 7499.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Ubiquitin-like protein UBL5 promotes the functional integrity of the Fanconi anemia pathway

    Oka, Y., Bekker-Jensen, Simon Holst & Mailand, Niels, 9 Apr 2015, In : E M B O Journal. 34, p. 1385-1398

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Lamin A/C-dependent interaction with 53BP1 promotes cellular responses to DNA damage

    Gibbs-Seymour, I., Markiewicz, E., Bekker-Jensen, Simon Holst, Mailand, Niels & Hutchison, C. J., Apr 2015, In : Aging Cell. 14, 2, p. 162-9 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    SLX4: not SIMply a nuclease scaffold?

    Gibbs-Seymour, I. & Mailand, Niels, 8 Jan 2015, In : Molecular Cell. 57, 1, p. 3-5 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Centriolar satellites: key mediators of centrosome functions

    Tollenaere, M. A. X., Mailand, Niels & Bekker-Jensen, Simon Holst, Jan 2015, In : Cellular and molecular life sciences : CMLS. 73, 1, p. 11-23 13 p.

    Research output: Contribution to journalReviewResearchpeer-review

  34. Published

    Proteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cells

    Bursomanno, S., Beli, P., Khan, A. M., Minocherhomji, S., Wagner, S. A., Bekker-Jensen, Simon Holst, Mailand, Niels, Choudhary, Chuna Ram, Hickson, Ian David & Liu, Ying, Jan 2015, In : DNA Repair. 25, p. 84-96 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Ubiquitin-SUMO Circuitry Controls Activated Fanconi Anemia ID Complex Dosage in Response to DNA Damage

    Gibbs-Seymour, I., Oka, Y., Rajendra, E., Weinert, B. T., Passmore, L. A., Patel, K. J., Olsen, Jesper Velgaard, Choudhary, Chuna Ram, Bekker-Jensen, Simon Holst & Mailand, Niels, Jan 2015, In : Molecular Cell. 57, 1, p. 150-64 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links

    Räschle, M., Smeenk, G., Hansen, R. K., Temu, T., Oka, Y., Hein, M. Y., Nagaraj, N., Long, D. T., Walter, J. C., Hofmann, K., Storchova, Z., Cox, J., Bekker-Jensen, Simon Holst, Mailand, Niels & Mann, Matthias, 2015, In : Science. 348, 6234, p. 539- 10 p., 1253671.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. 2014
  38. Published

    Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination

    Gao, M., Wei, W., Li, M. H., Wu, Y., Ba, Z., Jin, K., Li, M., Liao, Y., Adhikari, S., Chong, Z., Zhang, T., Guo, C., Tang, T., Zhu, B., Xu, X., Mailand, Niels, Yang, Y., Qi, Y. & Danielsen, J. M. R., May 2014, In : Cell Research. 24, 5, p. 532-41 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Molecular basis and regulation of OTULIN-LUBAC interaction

    Elliott, P. R., Nielsen, Sofie Vincents, Marco-Casanova, P., Fiil, Berthe Katrine, Keusekotten, K., Mailand, Niels, Freund, S. M. V., Gyrd-Hansen, M. & Komander, D., 2014, In : Molecular Cell. 54, 3, p. 335-348 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    UBL5 is essential for pre-mRNA splicing and sister chromatid cohesion in human cells

    Oka, Y., Varmark, H., Vitting-Seerup, Kristoffer, Beli, P., Waage, J. E., Hakobyan, A., Mistrik, M., Choudhary, Chuna Ram, Rohde, M., Bekker-Jensen, Simon Holst & Mailand, Niels, 2014, In : E M B O Reports. 15, 9, p. 956-964 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. 2013
  42. Published

    ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

    Toledo Lazaro, Luis Ignacio, Altmeyer, M., Rask, M., Lukas, Claudia, Larsen, D. H., Povlsen, L. K., Bekker-Jensen, Simon Holst, Mailand, Niels, Bartek, J. & Lukas, Jiri, 21 Nov 2013, In : Cell. 155, 5, p. 1088-1103 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    ATR-Chk1-APC/C-dependent stabilization of Cdc7-ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress

    Yamada, M., Watanabe, K., Mistrik, M., Vesela, E., Protivankova, I., Mailand, Niels, Lee, M. H., Masai, H., Lukas, Jiri & Bartek, J., 15 Nov 2013, In : Genes & Development. 27, 22, p. 2459-2472 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    A new cellular stress response that triggers centriolar satellite reorganization and ciliogenesis

    Villumsen, B. H., Danielsen, J. R., Povlsen, L., Sylvestersen, K. B., Merdes, A., Beli, P., Yang, Y., Choudhary, Chuna Ram, Nielsen, Michael Lund, Mailand, Niels & Bekker-Jensen, Simon Holst, 11 Oct 2013, In : E M B O Journal. 32, 23, p. 3029-3040

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling

    Damgaard, R. B., Fiil, Berthe Katrine, Speckmann, C., Yabal, M., Stadt, U. Z., Bekker-Jensen, Simon Holst, Jost, P. J., Ehl, S., Mailand, Niels & Gyrd-Hansen, M., 1 Jul 2013, In : E M B O Journal. 5, p. 1278-1295 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    OTULIN Restricts Met1-Linked Ubiquitination to Control Innate Immune Signaling

    Fiil, Berthe Katrine, Damgaard, R. B., Wagner, S. A., Keusekotten, K., Fritsch, M., Bekker-Jensen, Simon Holst, Mailand, Niels, Choudhary, Chuna Ram, Komander, D. & Gyrd-Hansen, M., 27 Jun 2013, In : Molecular Cell. 50, 6, p. 818-30 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response

    Poulsen, S. L., Hansen, R. K., Wagner, S. A., van Cuijk, L., van Belle, G. J., Streicher, W., Wikström, M., Choudhary, Chuna Ram, Houtsmuller, A. B., Marteijn, J. A., Bekker-Jensen, Simon Holst & Mailand, Niels, 10 Jun 2013, In : Journal of Cell Biology. 201, 6, p. 797-807 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Regulation of PCNA-protein interactions for genome stability

    Mailand, Niels, Gibbs-Seymour, I. & Bekker-Jensen, Simon Holst, May 2013, In : Nature Reviews. Molecular Cell Biology. 14, 5, p. 269-82 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    The deubiquitylating enzyme USP44 counteracts the DNA double-strand break response mediated by the RNF8 and RNF168 ubiquitin ligases

    Mosbech, A., Lukas, Claudia, Bekker-Jensen, Simon Holst & Mailand, Niels, 24 Apr 2013, In : Journal of Biological Chemistry. 288, p. 16579-16587 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Poly(ADP-ribosyl)ation links the chromatin remodeler SMARCA5/SNF2H to RNF168-dependent DNA damage signaling

    Smeenk, G., Wiegant, W. W., Luijsterburg, M. S., Costelloe, T., Romeijn, R. J., Pastink, A., van Attikum, H., Marteijn, J. A., Vermeulen, W., Sroczynski, N. & Mailand, Niels, 15 Feb 2013, In : Journal of Cell Science. 126, 4, p. 889-903 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. 2012
  52. Published

    Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass

    Povlsen, L. K., Beli, P., Wagner, S. A., Poulsen, S. L., Sylvestersen, K. B., Poulsen, J. W., Nielsen, Michael Lund, Bekker-Jensen, Simon Holst, Mailand, Niels & Choudhary, Chuna Ram, Oct 2012, In : Nature Cell Biology. 14, 10, p. 1089-98 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Ubiquitin and the DNA damage response: a new handle on histones

    Bekker-Jensen, Simon Holst & Mailand, Niels, 1 Sep 2012, In : Cell Cycle. 11, 17, p. 3153 1 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  54. Published

    TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes

    Gudjónsson, Thorkell, Altmeyer, M. F., Savic, V., Toledo Lazaro, Luis Ignacio, Dinant, C., Grøfte, M., Bartkova, J., Poulsen, M., Oka, Y., Bekker-Jensen, Simon Holst, Mailand, Niels, Neumann, B., Heriche, J., Shearer, R., Saunders, D., Bartek, J., Lukas, Jiri & Lukas, Claudia, 17 Aug 2012, In : Cell. 150, 4, p. 697-709 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure

    Luijsterburg, M. S., Acs, K., Ackermann, L., Wiegant, W. W., Bekker-Jensen, Simon Holst, Larsen, D. H., Khanna, K. K., van Attikum, H., Mailand, Niels & Dantuma, N. P., 2012, In : E M B O Journal. 31, 11, p. 2511-27 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger

    Danielsen, J. M. R., Povlsen, L. K., Villumsen, B. H., Streicher, W., Nilsson, Jakob, Wikström, M., Bekker-Jensen, Simon Holst & Mailand, Niels, 2012, In : Journal of Cell Biology. 197, 2, p. 179-87 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks

    Mosbech, A., Gibbs-Seymour, I., Kagias, K., Thorslund, T., Beli, P., Povlsen, L., Nielsen, Sofie Vincents, Smedegaard, S., Sedgwick, G., Lukas, Claudia, Hartmann-Petersen, Rasmus, Lukas, Jiri, Choudhary, Chuna Ram, Pocock, R. D. J., Bekker-Jensen, Simon Holst & Mailand, Niels, 2012, In : Nature Structural and Molecular Biology. 19, 11, p. 1084-92 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks

    Poulsen, M., Lukas, C., Lukas, J., Bekker-Jensen, Simon Holst & Mailand, Niels, 2012, In : Journal of Cell Biology. 197, 2, p. 189-99 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Published

    ICLs: a chicken without an egg

    Bekker-Jensen, Simon Holst & Mailand, Niels, 2012, In : Nature Reviews. Molecular Cell Biology. 13, 6, p. 342

    Research output: Contribution to journalReviewResearchpeer-review

  60. Published

    RNF8 and RNF168 but not HERC2 are required for DNA damage-induced ubiquitylation in chicken DT40 cells

    Østergaard, Vibe Hallundbæk, Pentzold, C., Pedersen, R. T., Iosif, S., Alpi, A., Bekker-Jensen, Simon Holst, Mailand, Niels & Lisby, Michael, 2012, In : D N A Repair. 11, 11, p. 892–905 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  61. Published

    The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

    Damgaard, R. B., Nachbur, U., Yabal, M., Wong, W. W., Fiil, Berthe Katrine, Kastirr, M., Rieser, E., Rickard, J. A., Bankovacki, A., Peschel, C., Ruland, J., Bekker-Jensen, Simon Holst, Mailand, Niels, Kaufmann, T., Strasser, A., Walczak, H., Silke, J., Jost, P. J. & Gyrd-Hansen, M., 2012, In : Molecular Cell. 46, 6, p. 746-58 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  62. 2011
  63. Published

    The ubiquitin- and SUMO-dependent signaling response to DNA double-strand breaks

    Bekker-Jensen, Simon Holst & Mailand, Niels, 12 Jun 2011, In : FEBS letters. 585, p. 2914-2919 6 p.

    Research output: Contribution to journalReviewResearchpeer-review

  64. Published

    Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level

    Danielsen, J. M. R., Sylvestersen, K. B., Bekker-Jensen, Simon Holst, Szklarczyk, D., Poulsen, J. W., Horn, H., Jensen, Lars Juhl, Mailand, Niels & Nielsen, Michael Lund, 1 Mar 2011, In : Molecular and Cellular Proteomics. 10, 3, p. M110.003590

    Research output: Contribution to journalJournal articleResearchpeer-review

  65. Published

    The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks

    Meerang, M., Ritz, D., Paliwal, S., Garajova, Z., Bosshard, M., Mailand, Niels, Janscak, P., Hübscher, U., Meyer, H. & Ramadan, K., 2011, In : Nature Cell Biology. 13, 11, p. 1376-82 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  66. 2010
  67. Published

    Assembly and function of DNA double-strand break repair foci in mammalian cells

    Bekker-Jensen, Simon Holst & Mailand, Niels, 10 Dec 2010, In : D N A Repair. 9, 12, p. 1219-28 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  68. HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

    Bekker-Jensen, Simon Holst, Danielsen, J. M. R., Fugger, K., Gromova, I., Nerstedt, A., Bartek, J., Lukas, Jiri & Mailand, Niels, 2010, In : Nature Cell Biology. 12, 1, p. 80-6; sup pp 1-12

    Research output: Contribution to journalLetterResearchpeer-review

  69. Human Cdc14A phosphatase modulates the G2/M transition through Cdc25A and Cdc25B

    Vázquez-Novelle, M. D., Mailand, Niels, Ovejero, S., Bueno, A. & Sacristán, M. P., 2010, In : Journal of Biological Chemistry. 285, 52, p. 40544-53 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  70. 2009
  71. Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities

    Fugger, K., Mistrik, M., Danielsen, J. R., Dinant, C., Falck, J., Bartek, J., Lukas, Jiri & Mailand, Niels, 2009, In : Journal of Cell Biology. 186, 5, p. 655-63 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  72. Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response

    Marteijn, J. A., Bekker-Jensen, Simon Holst, Mailand, Niels, Lans, H., Schwertman, P., Gourdin, A. M., Dantuma, N. P., Lukas, Jiri & Vermeulen, W., 2009, In : Journal of Cell Biology. 186, 6, p. 835-47 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  73. RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

    Doil, C., Mailand, Niels, Bekker-Jensen, Simon Holst, Ménard, Patrice, Larsen, D. H., Pepperkok, R., Ellenberg, J., Panier, S., Durocher, D., Bartek, J., Lukas, Jiri & Lukas, Claudia, 2009, In : Cell. 136, 3, p. 435-46 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  74. USP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of Claspin

    Faustrup, H., Bekker-Jensen, Simon Holst, Bartek, J., Lukas, Jiri & Mailand, Niels, 2009, In : Journal of Cell Biology. 184, 1, p. 13-9 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  75. 2008
  76. Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin

    Melander, F., Bekker-Jensen, Simon Holst, Falck, J., Bartek, J., Mailand, Niels & Lukas, Jiri, 21 Apr 2008, In : Journal of Cell Biology. 181, 2, p. 213-26 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  77. 2007
  78. Published

    Human Xip1 (C2orf13) is a novel regulator of cellular responses to DNA strand breaks

    Bekker-Jensen, Simon Holst, Fugger, K., Danielsen, J. R., Gromova, I., Sehested, M., Celis, J., Bartek, J., Lukas, Jiri & Mailand, Niels, 6 Jul 2007, In : Journal of Biological Chemistry. 282, 27, p. 19638-43 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  79. RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

    Mailand, Niels, Bekker-Jensen, Simon Holst, Faustrup, H., Melander, F., Bartek, J., Lukas, Claudia & Lukas, Jiri, 2007, In : Cell. 131, 5, p. 887-900 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  80. 2006
  81. TOPping up ATR activity

    Bartek, J. & Mailand, Niels, 10 Mar 2006, In : Cell. 124, 5, p. 888-90 3 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  82. Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation

    Liu, S., Bekker-Jensen, Simon Holst, Mailand, Niels, Lukas, Claudia, Bartek, J. & Lukas, Jiri, 2006, In : Molecular and Cellular Biology. 26, 16, p. 6056-64 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  83. Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress

    Mailand, Niels, Bekker-Jensen, Simon Holst, Bartek, J. & Lukas, Jiri, 2006, In : Molecular Cell. 23, 3, p. 307-18 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  84. The replication kinase Cdc7-Dbf4 promotes the interaction of the p150 subunit of chromatin assembly factor 1 with proliferating cell nuclear antigen

    Gérard, A., Koundrioukoff, S., Ramillon, V., Sergère, J., Mailand, Niels, Quivy, J. & Almouzni, G., 2006, In : E M B O Reports. 7, 8, p. 817-23 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  85. 2005
  86. CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis

    Mailand, Niels & Diffley, J. F. X., 23 Sep 2005, In : Cell. 122, 6, p. 915-26 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  87. 2004
  88. Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase

    Krämer, A., Mailand, Niels, Lukas, Claudia, Syljuåsen, R. G., Wilkinson, C. J., Nigg, E. A., Bartek, J. & Lukas, Jiri, Sep 2004, In : Nature Cell Biology. 6, 9, p. 884-91 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  89. 2002
  90. Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation

    Mailand, Niels, Lukas, Claudia, Kaiser, B. K., Jackson, P. K., Bartek, J. & Lukas, Jiri, Apr 2002, In : Nature Cell Biology. 4, 4, p. 317-22 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  91. Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability.

    Mailand, Niels, Podtelejnikov, A. V., Groth, Anja, Mann, M., Bartek, J. & Lukas, Jiri, 2002, In : EMBO Journal. 21, 21, p. 5911-20 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  92. 2001
  93. DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology

    Lukas, Claudia, Bartkova, J., Latella, L., Falck, J., Mailand, Niels, Schroeder, T., Sehested, M., Lukas, Jiri & Bartek, J., 1 Jul 2001, In : Cancer Research. 61, 13, p. 4990-3 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  94. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

    Falck, J., Mailand, Niels, Syljuåsen, R. G., Bartek, J. & Lukas, Jiri, 12 Apr 2001, In : Nature. 410, 6830, p. 842-7 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  95. 2000
  96. Rapid destruction of human Cdc25A in response to DNA damage

    Mailand, Niels, Falck, J., Lukas, Claudia, Syljuåsen, R. G., Welcker, M., Bartek, J. & Lukas, Jiri, 26 May 2000, In : Science (New York, N.Y.). 288, 5470, p. 1425-9 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  97. Involvement of Myc activity in a G(1)/S-promoting mechanism parallel to the pRb/E2F pathway

    Santoni-Rugiu, E., Falck, J., Mailand, Niels, Bartek, J. & Lukas, Jiri, May 2000, In : Molecular and Cellular Biology. 20, 10, p. 3497-509 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 13844358