Guillermo Montoya

Guillermo Montoya

Research director, professor


  1. 2020
  2. E-pub ahead of print

    Structures of the Cmr-β Complex Reveal the Regulation of the Immunity Mechanism of Type III-B CRISPR-Cas

    Sofos, N., Feng, M., Stella, Stefano, Pape, T., Fuglsang, Anders, Lin, Jinzhong, Huang, Q., Li, Y., She, Q. & Montoya, Guillermo, 24 Jul 2020, In : Molecular Cell.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Direct Observation of CRISPR-Cas12 Conformational Sampling by SM FRET and Cryo EM Reveals how Conformational Activation Promotes Catalysis and Resetting of the Endonuclease Activity

    Stella, Stefano, Mesa, Pablo, Thomsen, J., Paul, Bijoya, Alcon, P., Jensen, Simon Bo, Moses, M. E., Montoya, Guillermo & Hatzakis, Nikos, 7 Feb 2020, In : Biophysical Journal. 118, 3, p. 223A-224A 2 p.

    Research output: Contribution to journalConference abstract in journalResearch

  4. Published

    CRISPR-Cas12a: functional overview and applications

    Paul, Bijoya & Montoya, Guillermo, 2020, In : Biomedical Journal. 43, 1, p. 8-17

    Research output: Contribution to journalReviewResearchpeer-review

  5. Published

    Molecular Basis of the Mechanisms Controlling MASTL

    Hermida, D., Mortuza, G. B., Pedersen, A., Pozdnyakova, I., Nguyen, T. T. T. N., Maroto, M., Williamson, M., Ebersole, T., Cazzamali, G., Rand, Kasper Dyrberg, Olsen, Jesper Velgaard, Malumbres, M. & Montoya, Guillermo, 2020, In : Molecular & Cellular Proteomics. 19, 2, p. 326-343

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. 2019
  7. Published

    A Consensus Binding Motif for the PP4 Protein Phosphatase

    Ueki, Yumi, Kruse, Thomas, Weisser, Melanie, Sundell, G. N., Larsen, M. S. Y., Mendez, B. L., Jenkins, N. P., Garvanska, Dimitriya Hristoforova, Cressey, L., Zhang, G., Davey, N., Montoya, Guillermo, Ivarsson, Y., Kettenbach, A. N. & Nilsson, Jakob, 2019, In : Molecular Cell. 76, 6, p. 953-964.e6

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    High-Resolution Structure of Cas13b and Biochemical Characterization of RNA Targeting and Cleavage

    Slaymaker, I. M., Mesa, Pablo, Kellner, M. J., Kannan, S., Brignole, E., Koob, J., Feliciano, P. R., Stella, Stefano, Abudayyeh, O. O., Gootenberg, J. S., Strecker, J., Montoya, Guillermo & Zhang, F., 2019, In : Cell Reports. 26, 13, p. 3741-3751.e5 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Molecular architecture of the Jumonji C family histone demethylase KDM5B

    Dorosz, J., Kristensen, L. H., Aduri, N. G., Mirza, Osman Asghar, Lousen, R., Bucciarelli, S., Mehta, V., Sellés Baiget, Selene, Solbak, Sara Marie Øie, Bach, Anders, Mesa, Pablo, Hernandez, P. A., Montoya, Guillermo, Nguyen, T. T. T. N., Rand, Kasper Dyrberg, Boesen, T. & Gajhede, Michael, 2019, In : Scientific Reports. 9, 13 p., 4019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites

    Lundby, Alicia, Franciosa, Giulia, Emdal, Kristina Bennet, Refsgaard, J. C., Gnosa, Sebastian Peter, Bekker-Jensen, D. B., Secher, A., Maurya, S. R., Paul, I., Mendez, B. L., Kelstrup, C. D., Francavilla, C., Kveiborg, Marie, Montoya, Guillermo, Jensen, Lars Juhl & Olsen, Jesper Velgaard, 2019, In : Cell. 179, 2, p. 543-560

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Structure of Csx1-cOA4 complex reveals the basis of RNA decay in Type III-B CRISPR-Cas

    Molina, Rafael, Stella, Stefano, Feng, M., Sofos, N., Jauniskis, V., Pozdnyakova, I., López-Méndez, B., She, Q. & Montoya, Guillermo, 2019, In : Nature Communications. 10, 14 p., 4302.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. 2018
  13. Published

    Conformational Activation Promotes CRISPR-Cas12a Catalysis and Resetting of the Endonuclease Activity

    Stella, Stefano, Mesa, Pablo, Thomsen, J., Paul, Bijoya, Alcón, P., Jensen, Simon Bo, Saligram, B., Moses, M. E., Hatzakis, Nikos & Montoya, Guillermo, 13 Dec 2018, In : Cell. 175, 7, p. 1856-1871.e21 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    A Type III-B Cmr effector complex catalyzes the synthesis of cyclic oligoadenylate second messengers by cooperative substrate binding

    Han, W., Stella, Stefano, Zhang, Y., Guo, Tong, Sulek, Karolina, Peng-Lundgren, L., Montoya, Guillermo & She, Q., 2018, In : Nucleic Acids Research. 46, 19, p. 10319-10330 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    How do CRISPR-Cas RNA-guided endonucleases cut specific DNA regions for Genome Editing?

    Montoya, Guillermo, 2018, In : Acta Crystallographica Section A: Foundations and Advances. 74, p. E3 1 p.

    Research output: Contribution to journalConference abstract in journalResearch

  16. Published

    Molecular basis of Tousled-Like Kinase 2 activation

    Mortuza, G. B., Hermida, D., Pedersen, A., Segura-Bayona, S., López-Méndez, B., Redondo, P., Rüther, Patrick, Pozdnyakova, I., Garrote, A. M., Muñoz, I. G., Villamor-Payà, M., Jauset, C., Olsen, Jesper Velgaard, Stracker, T. H. & Montoya, Guillermo, 2018, In : Nature Communications. 9, 1, p. 2535 2535.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Understanding the indirect DNA read-out specificity of I-CreI Meganuclease

    Prieto, J., Redondo, P., López-Méndez, B., D'Abramo, M., Merino, N., Blanco, F. J., Duchateau, P., Montoya, Guillermo & Molina, Rafael, 2018, In : Scientific Reports. 8, p. 1-9 10286.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. 2017
  19. Published

    Structure and dynamics of mesophilic variants from the homing endonuclease I-DmoI

    Alba, J., Marcaida, M. J., Prieto, J., Montoya, Guillermo, Molina, Rafael & D'Abramo, M., Dec 2017, In : Journal of Computer - Aided Molecular Design. 31, 12, p. 1063-1072 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Class 2 CRISPR-Cas RNA-guided endonucleases: Swiss Army knives of genome editing

    Stella, Stefano, Alcón, P. & Montoya, Guillermo, Nov 2017, In : Nature Structural and Molecular Biology. 24, 11, p. 882-892 11 p.

    Research output: Contribution to journalReviewResearchpeer-review

  21. Published

    Allosteric regulation of Csx1, a type IIIB-associated CARF domain ribonuclease by RNAs carrying a tetraadenylate tail

    Han, W., Pan, S., López-Méndez, B., Montoya, Guillermo & She, Q., 13 Oct 2017, In : Nucleic Acids Research. 45, 18, p. 10740-10750 11 p., gkx726.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Assembly of Francisella novicida Cpf1 endonuclease in complex with guide RNA and target DNA

    Alcón, P., Montoya, Guillermo & Stella, Stefano, 1 Jul 2017, In : Acta Crystallographica Section F: Structural Biology Communications. 73, Pt 7, p. 409-415 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Structure of the Cpf1 endonuclease R-loop complex after target DNA cleavage

    Stella, Stefano, Alcón, P. & Montoya, Guillermo, 22 Jun 2017, In : Nature. 546, 7659, p. 559-563 5 p.

    Research output: Contribution to journalLetterResearchpeer-review

  24. Published

    A novel TPR-BEN domain interaction mediates PICH-BEND3 association

    Pitchai, G. P., Kaulich, M., Bizard, Anna Helene, Mesa, Pablo, Yao, Q., Sarlos, K., Streicher, W. W., Nigg, E. A., Montoya, Guillermo & Hickson, Ian David, 2017, In : Nucleic Acids Research. 19, 2, p. 11413–11424

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Electron Microscopy Structural Insights into CPAP Oligomeric Behavior: A Plausible Assembly Process of a Supramolecular Scaffold of the Centrosome

    Alvarez-Cabrera, A. L., Delgado, S., Gil-Carton, D., Mortuza, G. B., Montoya, Guillermo, Sorzano, C. O. S., Tang, T. K. & Carazo, J. M., 2017, In : Frontiers in Molecular Biosciences. 4, 14 p., 17.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. 2016
  27. Published

    Molecular architecture of the recombinant human MCM2-7 helicase in complex with nucleotides and DNA

    Boskovic, J., Bragado-Nilsson, E., Saligram Prabhakar, B., Yefimenko, I., Martínez-Gago, J., Muñoz, S., Méndez, J. & Montoya, Guillermo, 16 Sep 2016, In : Cell Cycle. 15, 18, p. 2431-40 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Characterization of the NTPR and BD1 interacting domains of the human PICH-BEND3 complex

    Pitchai, G. P., Hickson, Ian David, Streicher, W., Montoya, Guillermo & Mesa, Pablo, Aug 2016, In : Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online. 72, 8, p. 646-651 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    The genome editing revolution: A CRISPR-Cas TALE off-target story

    Stella, Stefano & Montoya, Guillermo, Jul 2016, In : BioEssays. 38, S1, p. S4-S13

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Structure of the I-SceI nuclease complexed with its dsDNA target and three catalytic metal ions

    Prieto, J., Redondo, P., Merino, N., Villate, M., Montoya, Guillermo, Blanco, F. J. & Molina, Rafael, Jun 2016, In : Acta crystallographica. Section F, Structural biology communications. 72, Pt 6, p. 473-9 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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