01 July 2013

OTULIN Restricts Met1-Linked Ubiquitination to Control Innate Immune Signaling

click to open graphical abstractResearchers from Novo Nordisk Foundation Center for Protein Research find that correct regulation of polyubiquitin assembled through Met1 (Met1-Ub) plays a critical role in immune signalling elicited by bacterial components. The findings of the study, published in Molecular Cell, may have implications for our understanding of how innate immune responses are regulated. 

 

Title: OTULIN Restricts Met1-Linked Ubiquitination to Control Innate Immune Signaling

Authors: Berthe Katrine Fiil, Rune Busk Damgaard, Sebastian Alexander Wagner, Kirstin Keusekotten, Melanie Fritsch, Simon Bekker-Jensen, Niels Mailand, Chunaram Choudhary, David Komander, Mads Gyrd-Hansen

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