Protein Signaling Program
Blegdamsvej 3, 2200 København N, Bygning 6, Building: 06-1-32A
The focus of the Lukas Group is to explore how proteins that guard the integrity of the human genome, assemble into functional pathways, how they organize themselves in the cell nucleus, and how they communicate with external and internal environment to shield DNA against heritable and disease-predisposing mutations.
In my work specifically we employ automated high-content micorscopy and super-resolution microsocopy to understand the nuclear response to DNA damage in the 3D chromatin space of the cell. Our key findings include that the central DNA repair protein 53BP1 actively shields DNA double-strand breaks against illegitimate processing throughout interphase of the cell cycle and that disruption of this mechanism is exploited in BRCA1-deficient cancers to acquire resistance to chemotherapeutic drugs.