Niels Skotte
Assistant Professor, Visiting professor
Molecular and Cellular Pharmacology
Jagtvej 160
2100 København Ø
Mann Group
Blegdamsvej 3B
2200 København N
- 2024
- Published
Deletion of CaMKIIα disrupts glucose metabolism, glutamate uptake, and synaptic energetics in the cerebral cortex
Andersen, Jens Velde, Westi, Emil Winther, Griem-Krey, Nane, Skotte, Niels Henning, Schousboe, Arne, Aldana, Blanca & Wellendorph, Petrine, 2024, In: Journal of Neurochemistry. 168, 5, p. 704-718Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
Characterising the RNA-binding protein atlas of the mammalian brain uncovers RBM5 misregulation in mouse models of Huntington's disease
Mullari, M., Fossat, Nicolas Julien, Skotte, Niels Henning, Asenjo-Martinez, A., Humphreys, D. T., Bukh, Jens, Kirkeby, Agnete, Scheel, Troels Kasper Høyer & Nielsen, Michael Lund, 2023, In: Nature Communications. 14, 20 p., 4348.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dysregulated COMT Expression in Fragile X Syndrome
Utami, K. H., Yusof, N. A. B. M., Garcia-Miralles, M., Skotte, Niels Henning, Nama, S., Sampath, P., Langley, S. R. & Pouladi, M. A., 2023, In: NeuroMolecular Medicine. 25, p. 644–649Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
D13 Saliva biomarker discovery in Huntington’s disease
Qvist, Filippa Liliendahl, Hellem, M. N., Nielsen, Jørgen Erik, Mann, Matthias & Skotte, Niels Henning, 2022, In: Journal of Neurology, Neurosurgery and Psychiatry. 93, Suppl. 1, p. A24-A25Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Progressive Mitochondrial Dysfunction of Striatal Synapses in R6/2 Mouse Model of Huntington's Disease
Petersen, M. H., Willert, C. W., Andersen, Jens Velde, Madsen, M., Waagepetersen, Helle S., Skotte, Niels Henning & Nørremølle, Anne, 2022, In: Journal of Huntington's disease. 11, 2, p. 121-140Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer's disease
Andersen, Jens Velde, Skotte, Niels Henning, Christensen, S. K., Polli, F. S., Shabani, M., Markussen, K. H., Haukedal, H., Westi, Emil Winther, Diaz-delCastillo, M., Sun, R. C., Kohlmeier, Kristi Anne, Schousboe, Arne, Gentry, M. S., Tanila, H., Freude, Kristine, Aldana, Blanca, Mann, Matthias & Waagepetersen, Helle S., 2021, In: Cell Death & Disease. 12, 11, 13 p., 954 .Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Compromised IGF signaling causes caspase-6 activation in Huntington disease
Skotte, Niels Henning, Pouladi, M. A., Ehrnhoefer, D. E., Huynh, K., Qiu, X., Nielsen, S. M. B., Nielsen, T. T., Nørremølle, Anne & Hayden, M. R., 2020, In: Experimental Neurology. 332, 113396.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Integrative Analysis Identifies Key Molecular Signatures Underlying Neurodevelopmental Deficits in Fragile X Syndrome
Utami, K. H., Skotte, Niels Henning, Colaço, A. R., Yusof, N. A. B. M., Sim, B., Yeo, X. Y., Bae, H., Garcia-Miralles, M., Radulescu, C. I., Chen, Q., Chaldaiopoulou, G., Liany, H., Nama, S., Peteri, U. A., Sampath, P., Castrén, M. L., Jung, S., Mann, Matthias & Pouladi, M. A., 2020, In: Biological Psychiatry. 88, 6, p. 500-511Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Functional Differences between Synaptic Mitochondria from the Striatum and the Cerebral Cortex
Petersen, M. H., Willert, C. W., Andersen, Jens Velde, Waagepetersen, Helle S., Skotte, Niels Henning & Nørremølle, Anne, May 2019, In: Neuroscience. 406, p. 432-443 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound
Ehrnhoefer, D. E., Skotte, N. H., Reinshagen, J., Qiu, X., Windshuegel, B., Jaishankar, P., Ladha, S., Petina, O., Khankischpur, M., Nguyen, Y. T. N., Caron, N. S., Razeto, A., Zu Rheda, M. M., Deng, Y., Huynh, K. T., Wittig, I., Gribbon, P., Renslo, A. R., Geffken, D., Gul, S. & 1 others, , 2019, In: Cell Chemical Biology. 26, 9, p. 1295-1305.e6Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Enhanced cerebral branched-chain amino acid metabolism in R6/2 mouse model of Huntington's disease
Andersen, Jens Velde, Skotte, Niels Henning, Aldana, Blanca, Nørremølle, Anne & Waagepetersen, Helle S., 2019, In: Cellular and Molecular Life Sciences. 76, 12, p. 2449-2461Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
Huntingtin suppression restores cognitive function in a mouse model of Huntington's disease
Southwell, A. L., Kordasiewicz, H. B., Langbehn, D., Skotte, Niels Henning, Parsons, M. P., Villanueva, Erika Bianca, Caron, N. S., Østergaard, M. E., Anderson, L. M., Xie, Y., Cengio, L. D., Findlay-Black, H., Doty, C. N., Fitsimmons, B., Swayze, E. E., Seth, P. P., Raymond, L. A., Frank Bennett, C. & Hayden, M. R., 2018, In: Science Translational Medicine. 10, 461, p. 1-12 eaar3959.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Integrative Characterization of the R6/2 Mouse Model of Huntington's Disease Reveals Dysfunctional Astrocyte Metabolism
Skotte, Niels Henning, Andersen, Jens Velde, Santos, A., Aldana, Blanca, Willert, C. W., Nørremølle, Anne, Waagepetersen, Helle S. & Nielsen, Michael Lund, 2018, In: Cell Reports. 23, 7, p. 2211-2224 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Site-specific characterization of endogenous SUMOylation across species and organs
Hendriks, Ivo Alexander, Lyon, D., Su, D., Skotte, Niels Henning, Daniel, J. A., Jensen, Lars Juhl & Nielsen, Michael Lund, 2018, In: Nature Communications. 9, p. 1-17 2456.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles
Southwell, A. L., Skotte, N. H., Villanueva, E. B., Østergaard, M. E., Gu, X., Kordasiewicz, H. B., Kay, C., Cheung, D., Xie, Y., Waltl, S., Dal Cengio, L., Findlay-Black, H., Doty, C. N., Petoukhov, E., Iworima, D., Slama, R., Ooi, J., Pouladi, M. A., Yang, X. W., Swayze, E. E. & 2 others, , 15 Mar 2017, In: Human Molecular Genetics. 26, 6, p. 1115-1132 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
Palmitoylation of caspase-6 by HIP14 regulates its activation
Skotte, Niels Henning, Sanders, S. S., Singaraja, R. R., Ehrnhoefer, D. E., Vaid, K., Qiu, X., Kannan, S., Verma, C. & Hayden, M. R., 2017, In: Cell Death and Differentiation. 24, p. 433-444 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD
Riechers, S., Butland, S., Deng, Y., Skotte, Niels Henning, Ehrnhoefer, D. E., Russ, J., Laine, J., Laroche, M., Pouladi, M. A., Wanker, E. E., Hayden, M. R. & Graham, R. K., 15 Apr 2016, In: Human Molecular Genetics. 25, 8, p. 1600-18 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
Huntingtin Haplotypes Provide Prioritized Target Panels for Allele-specific Silencing in Huntington Disease Patients of European Ancestry
Kay, C., Collins, J. A., Skotte, Niels Henning, Southwell, A. L., Warby, S. C., Caron, N. S., Doty, C. N., Nguyen, B., Griguoli, A., Ross, C. J., Squitieri, F. & Hayden, M. R., Nov 2015, In: Molecular Therapy. 23, 11, p. 1759-71 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
In vivo evaluation of candidate allele-specific mutant huntingtin gene silencing antisense oligonucleotides
Southwell, A. L., Skotte, Niels Henning, Kordasiewicz, H. B., Østergaard, M. E., Watt, A. T., Carroll, J. B., Doty, C. N., Villanueva, Erika Bianca, Petoukhov, E., Vaid, K., Xie, Y., Freier, S. M., Swayze, E. E., Seth, P. P., Bennett, C. F. & Hayden, M. R., Dec 2014, In: Molecular Therapy. 22, 12, p. 2093-106 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
Personalized gene silencing therapeutics for Huntington disease
Kay, C., Skotte, Niels Henning, Southwell, A. L. & Hayden, M. R., Jul 2014, In: Clinical Genetics. 86, 1, p. 29-36 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response
Rotblat, B., Southwell, A. L., Ehrnhoefer, D. E., Skotte, N. H., Metzler, M., Franciosi, S., Leprivier, G., Somasekharan, S. P., Barokas, A., Deng, Y., Tang, T., Mathers, J., Cetinbas, N., Daugaard, M., Kwok, B., Li, L., Carnie, C. J., Fink, D., Nitsch, R., Galpin, J. D. & 5 others, , 25 Feb 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 8, p. 3032-7 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin
Ehrnhoefer, D. E., Skotte, Niels Henning, Ladha, S., Nguyen, Y. T. N., Qiu, X., Deng, Y., Huynh, K. T., Engemann, S., Nielsen, S. M., Becanovic, K., Leavitt, B. R., Hasholt, Lis Frydenreich & Hayden, M. R., 1 Feb 2014, In: Human Molecular Genetics. 23, 3, p. 717-29 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Allele-specific suppression of mutant huntingtin using antisense oligonucleotides: providing a therapeutic option for all Huntington disease patients
Skotte, Niels Henning, Southwell, A. L., Østergaard, M. E., Carroll, J. B., Warby, S. C., Doty, C. N., Petoukhov, E., Vaid, K., Kordasiewicz, H., Watt, A. T., Freier, S. M., Hung, G., Seth, P. P., Bennett, C. F., Swayze, E. E. & Hayden, M. R., 2014, In: PLOS ONE. 9, 9, p. e107434Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS
Østergaard, M. E., Southwell, A. L., Kordasiewicz, H., Watt, A. T., Skotte, Niels Henning, Doty, C. N., Vaid, K., Villanueva, Erika Bianca, Swayze, E. E., Bennett, C. F., Hayden, M. R. & Seth, P. P., Nov 2013, In: Nucleic Acids Research. 41, 21, p. 9634-50 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
A fully humanized transgenic mouse model of Huntington disease
Southwell, A. L., Warby, S. C., Carroll, J. B., Doty, C. N., Skotte, Niels Henning, Zhang, W., Villanueva, Erika Bianca, Kovalik, V., Xie, Y., Pouladi, M. A., Collins, J. A., Yang, X. W., Franciosi, S. & Hayden, M. R., 1 Jan 2013, In: Human Molecular Genetics. 22, 1, p. 18-34 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
Antisense oligonucleotide therapeutics for inherited neurodegenerative diseases
Southwell, A. L., Skotte, Niels Henning, Bennett, C. F. & Hayden, M. R., Nov 2012, In: Trends in Molecular Medicine. 18, 11, p. 634-43 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice
Uribe, V., Wong, B. K. Y., Graham, R. K., Cusack, C. L., Skotte, N. H., Pouladi, M. A., Xie, Y., Feinberg, K., Ou, Y., Ouyang, Y., Deng, Y., Franciosi, S., Bissada, N., Spreeuw, A., Zhang, W., Ehrnhoefer, D. E., Vaid, K., Miller, F. D., Deshmukh, M., Howland, D. & 1 others, , 1 May 2012, In: Human Molecular Genetics. 21, 9, p. 1954-67 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
Polycystin-1: a key player in hereditary cystic kidney and liver disorders
Skotte, Niels Henning, Dec 2011, In: Clinical Genetics. 80, 6, p. 507-9 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Potent and selective antisense oligonucleotides targeting single-nucleotide polymorphisms in the Huntington disease gene / allele-specific silencing of mutant huntingtin
Carroll, J. B., Warby, S. C., Southwell, A. L., Doty, C. N., Greenlee, S., Skotte, Niels Henning, Hung, G., Bennett, C. F., Freier, S. M. & Hayden, M. R., Dec 2011, In: Molecular therapy : the journal of the American Society of Gene Therapy. 19, 12, p. 2178-85 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
- Published
A quantitative method for the specific assessment of caspase-6 activity in cell culture
Ehrnhoefer, D. E., Skotte, Niels Henning, Savill, J., Nguyen, Y. T. N., Ladha, S., Cao, L., Dullaghan, E. & Hayden, M. R., 2011, In: PLOS ONE. 6, 11, p. e27680Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
Reduced gluconeogenesis and lactate clearance in Huntington's disease
Josefsen, K., Nielsen, S. M. B., Campos, A., Seifert, T., Hasholt, Lis Frydenreich, Nielsen, Jørgen Erik, Nørremølle, Anne, Skotte, Niels Henning, Secher, Niels H. & Quistorff, B., 1 Dec 2010, In: Neurobiology of Disease. 40, 3, p. 656-62 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression
Pouladi, M. A., Xie, Y., Skotte, Niels Henning, Ehrnhoefer, D. E., Graham, R. K., Kim, J. E., Bissada, N., Yang, X. W., Paganetti, P., Friedlander, R. M., Leavitt, B. R. & Hayden, M. R., 15 Apr 2010, In: Human Molecular Genetics. 19, 8, p. 1528-38 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 7791
Most downloads
-
255
downloads
Integrative Characterization of the R6/2 Mouse Model of Huntington's Disease Reveals Dysfunctional Astrocyte Metabolism
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
218
downloads
Site-specific characterization of endogenous SUMOylation across species and organs
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
201
downloads
Potent and selective antisense oligonucleotides targeting single-nucleotide polymorphisms in the Huntington disease gene / allele-specific silencing of mutant huntingtin
Research output: Contribution to journal › Journal article › Research › peer-review
Published