The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage

Research output: Contribution to journalJournal articlepeer-review

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The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage. / Larsen, Dorthe H; Hari, Flurina; Clapperton, Julie A; Gwerder, Myriam; Gutsche, Katrin; Altmeyer, Matthias; Jungmichel, Stephanie; Toledo Lazaro, Luis Ignacio; Fink, Daniel; Rask, Maj-Britt; Grøfte, Merete; Lukas, Claudia; Nielsen, Michael L; Smerdon, Stephen J; Lukas, Jiri; Stucki, Manuel.

In: Nature Cell Biology, Vol. 16, No. 8, 08.2014, p. 792-803.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Larsen, DH, Hari, F, Clapperton, JA, Gwerder, M, Gutsche, K, Altmeyer, M, Jungmichel, S, Toledo Lazaro, LI, Fink, D, Rask, M-B, Grøfte, M, Lukas, C, Nielsen, ML, Smerdon, SJ, Lukas, J & Stucki, M 2014, 'The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage', Nature Cell Biology, vol. 16, no. 8, pp. 792-803. https://doi.org/10.1038/ncb3007

APA

Larsen, D. H., Hari, F., Clapperton, J. A., Gwerder, M., Gutsche, K., Altmeyer, M., Jungmichel, S., Toledo Lazaro, L. I., Fink, D., Rask, M-B., Grøfte, M., Lukas, C., Nielsen, M. L., Smerdon, S. J., Lukas, J., & Stucki, M. (2014). The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage. Nature Cell Biology, 16(8), 792-803. https://doi.org/10.1038/ncb3007

Vancouver

Larsen DH, Hari F, Clapperton JA, Gwerder M, Gutsche K, Altmeyer M et al. The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage. Nature Cell Biology. 2014 Aug;16(8):792-803. https://doi.org/10.1038/ncb3007

Author

Larsen, Dorthe H ; Hari, Flurina ; Clapperton, Julie A ; Gwerder, Myriam ; Gutsche, Katrin ; Altmeyer, Matthias ; Jungmichel, Stephanie ; Toledo Lazaro, Luis Ignacio ; Fink, Daniel ; Rask, Maj-Britt ; Grøfte, Merete ; Lukas, Claudia ; Nielsen, Michael L ; Smerdon, Stephen J ; Lukas, Jiri ; Stucki, Manuel. / The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage. In: Nature Cell Biology. 2014 ; Vol. 16, No. 8. pp. 792-803.

Bibtex

@article{30ef3b150a814d668b9d7698c914c206,
title = "The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage",
abstract = "Chromosome breakage elicits transient silencing of ribosomal RNA synthesis, but the mechanisms involved remained elusive. Here we discover an in trans signalling mechanism that triggers pan-nuclear silencing of rRNA transcription in response to DNA damage. This is associated with transient recruitment of the Nijmegen breakage syndrome protein 1 (NBS1), a central regulator of DNA damage responses, into the nucleoli. We further identify TCOF1 (also known as Treacle), a nucleolar factor implicated in ribosome biogenesis and mutated in Treacher Collins syndrome, as an interaction partner of NBS1, and demonstrate that NBS1 translocation and accumulation in the nucleoli is Treacle dependent. Finally, we provide evidence that Treacle-mediated NBS1 recruitment into the nucleoli regulates rRNA silencing in trans in the presence of distant chromosome breaks.",
author = "Larsen, {Dorthe H} and Flurina Hari and Clapperton, {Julie A} and Myriam Gwerder and Katrin Gutsche and Matthias Altmeyer and Stephanie Jungmichel and {Toledo Lazaro}, {Luis Ignacio} and Daniel Fink and Maj-Britt Rask and Merete Gr{\o}fte and Claudia Lukas and Nielsen, {Michael L} and Smerdon, {Stephen J} and Jiri Lukas and Manuel Stucki",
year = "2014",
month = aug,
doi = "10.1038/ncb3007",
language = "English",
volume = "16",
pages = "792--803",
journal = "Nature Cell Biology",
issn = "1465-7392",
publisher = "nature publishing group",
number = "8",

}

RIS

TY - JOUR

T1 - The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage

AU - Larsen, Dorthe H

AU - Hari, Flurina

AU - Clapperton, Julie A

AU - Gwerder, Myriam

AU - Gutsche, Katrin

AU - Altmeyer, Matthias

AU - Jungmichel, Stephanie

AU - Toledo Lazaro, Luis Ignacio

AU - Fink, Daniel

AU - Rask, Maj-Britt

AU - Grøfte, Merete

AU - Lukas, Claudia

AU - Nielsen, Michael L

AU - Smerdon, Stephen J

AU - Lukas, Jiri

AU - Stucki, Manuel

PY - 2014/8

Y1 - 2014/8

N2 - Chromosome breakage elicits transient silencing of ribosomal RNA synthesis, but the mechanisms involved remained elusive. Here we discover an in trans signalling mechanism that triggers pan-nuclear silencing of rRNA transcription in response to DNA damage. This is associated with transient recruitment of the Nijmegen breakage syndrome protein 1 (NBS1), a central regulator of DNA damage responses, into the nucleoli. We further identify TCOF1 (also known as Treacle), a nucleolar factor implicated in ribosome biogenesis and mutated in Treacher Collins syndrome, as an interaction partner of NBS1, and demonstrate that NBS1 translocation and accumulation in the nucleoli is Treacle dependent. Finally, we provide evidence that Treacle-mediated NBS1 recruitment into the nucleoli regulates rRNA silencing in trans in the presence of distant chromosome breaks.

AB - Chromosome breakage elicits transient silencing of ribosomal RNA synthesis, but the mechanisms involved remained elusive. Here we discover an in trans signalling mechanism that triggers pan-nuclear silencing of rRNA transcription in response to DNA damage. This is associated with transient recruitment of the Nijmegen breakage syndrome protein 1 (NBS1), a central regulator of DNA damage responses, into the nucleoli. We further identify TCOF1 (also known as Treacle), a nucleolar factor implicated in ribosome biogenesis and mutated in Treacher Collins syndrome, as an interaction partner of NBS1, and demonstrate that NBS1 translocation and accumulation in the nucleoli is Treacle dependent. Finally, we provide evidence that Treacle-mediated NBS1 recruitment into the nucleoli regulates rRNA silencing in trans in the presence of distant chromosome breaks.

U2 - 10.1038/ncb3007

DO - 10.1038/ncb3007

M3 - Journal article

C2 - 25064736

VL - 16

SP - 792

EP - 803

JO - Nature Cell Biology

JF - Nature Cell Biology

SN - 1465-7392

IS - 8

ER -

ID: 122495483