PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination

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Standard

PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination. / Falcão, Ana Mendanha; Meijer, Mandy; Scaglione, Antonella; Rinwa, Puneet; Agirre, Eneritz; Liang, Jialiang; Larsen, Sara C; Heskol, Abeer; Frawley, Rebecca; Klingener, Michael; Varas-Godoy, Manuel; Raposo, Alexandre A S F; Ernfors, Patrik; Castro, Diogo S; Nielsen, Michael L.; Casaccia, Patrizia; Castelo-Branco, Gonçalo.

In: Cell Reports, Vol. 27, No. 4, 2019, p. 1090-1102.e10.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Falcão, AM, Meijer, M, Scaglione, A, Rinwa, P, Agirre, E, Liang, J, Larsen, SC, Heskol, A, Frawley, R, Klingener, M, Varas-Godoy, M, Raposo, AASF, Ernfors, P, Castro, DS, Nielsen, ML, Casaccia, P & Castelo-Branco, G 2019, 'PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination', Cell Reports, vol. 27, no. 4, pp. 1090-1102.e10. https://doi.org/10.1016/j.celrep.2019.03.108

APA

Falcão, A. M., Meijer, M., Scaglione, A., Rinwa, P., Agirre, E., Liang, J., Larsen, S. C., Heskol, A., Frawley, R., Klingener, M., Varas-Godoy, M., Raposo, A. A. S. F., Ernfors, P., Castro, D. S., Nielsen, M. L., Casaccia, P., & Castelo-Branco, G. (2019). PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination. Cell Reports, 27(4), 1090-1102.e10. https://doi.org/10.1016/j.celrep.2019.03.108

Vancouver

Falcão AM, Meijer M, Scaglione A, Rinwa P, Agirre E, Liang J et al. PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination. Cell Reports. 2019;27(4):1090-1102.e10. https://doi.org/10.1016/j.celrep.2019.03.108

Author

Falcão, Ana Mendanha ; Meijer, Mandy ; Scaglione, Antonella ; Rinwa, Puneet ; Agirre, Eneritz ; Liang, Jialiang ; Larsen, Sara C ; Heskol, Abeer ; Frawley, Rebecca ; Klingener, Michael ; Varas-Godoy, Manuel ; Raposo, Alexandre A S F ; Ernfors, Patrik ; Castro, Diogo S ; Nielsen, Michael L. ; Casaccia, Patrizia ; Castelo-Branco, Gonçalo. / PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination. In: Cell Reports. 2019 ; Vol. 27, No. 4. pp. 1090-1102.e10.

Bibtex

@article{4ab1a8697b4f4d7a975d34a9a760ff3e,
title = "PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination",
abstract = "Citrullination, the deimination of peptidylarginine residues into peptidylcitrulline, has been implicated in the etiology of several diseases. In multiple sclerosis, citrullination is thought to be a major driver of pathology through hypercitrullination and destabilization of myelin. As such, inhibition of citrullination has been suggested as a therapeutic strategy for MS. Here, in contrast, we show that citrullination by peptidylarginine deiminase 2 (PAD2) contributes to normal oligodendrocyte differentiation, myelination, and motor function. We identify several targets for PAD2, including myelin and chromatin-related proteins, implicating PAD2 in epigenomic regulation. Accordingly, we observe that PAD2 inhibition and its knockdown affect chromatin accessibility and prevent the upregulation of oligodendrocyte differentiation genes. Moreover, mice lacking PAD2 display motor dysfunction and a decreased number of myelinated axons in the corpus callosum. We conclude that citrullination contributes to proper oligodendrocyte lineage progression and myelination.",
author = "Falc{\~a}o, {Ana Mendanha} and Mandy Meijer and Antonella Scaglione and Puneet Rinwa and Eneritz Agirre and Jialiang Liang and Larsen, {Sara C} and Abeer Heskol and Rebecca Frawley and Michael Klingener and Manuel Varas-Godoy and Raposo, {Alexandre A S F} and Patrik Ernfors and Castro, {Diogo S} and Nielsen, {Michael L.} and Patrizia Casaccia and Gon{\c c}alo Castelo-Branco",
year = "2019",
doi = "10.1016/j.celrep.2019.03.108",
language = "English",
volume = "27",
pages = "1090--1102.e10",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "4",

}

RIS

TY - JOUR

T1 - PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination

AU - Falcão, Ana Mendanha

AU - Meijer, Mandy

AU - Scaglione, Antonella

AU - Rinwa, Puneet

AU - Agirre, Eneritz

AU - Liang, Jialiang

AU - Larsen, Sara C

AU - Heskol, Abeer

AU - Frawley, Rebecca

AU - Klingener, Michael

AU - Varas-Godoy, Manuel

AU - Raposo, Alexandre A S F

AU - Ernfors, Patrik

AU - Castro, Diogo S

AU - Nielsen, Michael L.

AU - Casaccia, Patrizia

AU - Castelo-Branco, Gonçalo

PY - 2019

Y1 - 2019

N2 - Citrullination, the deimination of peptidylarginine residues into peptidylcitrulline, has been implicated in the etiology of several diseases. In multiple sclerosis, citrullination is thought to be a major driver of pathology through hypercitrullination and destabilization of myelin. As such, inhibition of citrullination has been suggested as a therapeutic strategy for MS. Here, in contrast, we show that citrullination by peptidylarginine deiminase 2 (PAD2) contributes to normal oligodendrocyte differentiation, myelination, and motor function. We identify several targets for PAD2, including myelin and chromatin-related proteins, implicating PAD2 in epigenomic regulation. Accordingly, we observe that PAD2 inhibition and its knockdown affect chromatin accessibility and prevent the upregulation of oligodendrocyte differentiation genes. Moreover, mice lacking PAD2 display motor dysfunction and a decreased number of myelinated axons in the corpus callosum. We conclude that citrullination contributes to proper oligodendrocyte lineage progression and myelination.

AB - Citrullination, the deimination of peptidylarginine residues into peptidylcitrulline, has been implicated in the etiology of several diseases. In multiple sclerosis, citrullination is thought to be a major driver of pathology through hypercitrullination and destabilization of myelin. As such, inhibition of citrullination has been suggested as a therapeutic strategy for MS. Here, in contrast, we show that citrullination by peptidylarginine deiminase 2 (PAD2) contributes to normal oligodendrocyte differentiation, myelination, and motor function. We identify several targets for PAD2, including myelin and chromatin-related proteins, implicating PAD2 in epigenomic regulation. Accordingly, we observe that PAD2 inhibition and its knockdown affect chromatin accessibility and prevent the upregulation of oligodendrocyte differentiation genes. Moreover, mice lacking PAD2 display motor dysfunction and a decreased number of myelinated axons in the corpus callosum. We conclude that citrullination contributes to proper oligodendrocyte lineage progression and myelination.

U2 - 10.1016/j.celrep.2019.03.108

DO - 10.1016/j.celrep.2019.03.108

M3 - Journal article

C2 - 31018126

VL - 27

SP - 1090-1102.e10

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 4

ER -

ID: 216969532