Michael Lund Nielsen

Michael Lund Nielsen

professor, group leader


  1. Published

    A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles

    Wagner, S. A., Beli, P., Weinert, B. T., Nielsen, Michael Lund, Cox, J., Mann, Matthias & Choudhary, Chuna Ram, 1 Oct 2011, In : Molecular and Cellular Proteomics. 10, 10, p. M111.013284

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. A dual pressure linear ion trap orbitrap instrument with very high sequencing speed

    Olsen, Jesper Velgaard, Schwartz, J. C., Griep-Raming, J., Nielsen, Michael Lund, Damoc, E., Denisov, E., Lange, O., Remes, P., Taylor, D., Splendore, M., Wouters, E. R., Senko, M., Makarov, A., Mann, Matthias & Horning, S., 2009, In : Molecular and Cellular Proteomics. 8, 12, p. 2759-69 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    A new cellular stress response that triggers centriolar satellite reorganization and ciliogenesis

    Villumsen, B. H., Danielsen, J. R., Povlsen, L., Sylvestersen, K. B., Merdes, A., Beli, P., Yang, Y., Choudhary, Chuna Ram, Nielsen, Michael Lund, Mailand, Niels & Bekker-Jensen, Simon Holst, 11 Oct 2013, In : E M B O Journal. 32, 23, p. 3029-3040

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    A two-step protein quality control pathway for a misfolded DJ-1 variant in fission yeast

    Mathiassen, S. G., Larsen, I. B., Poulsen, E. G., Madsen, C. T., Papaleo, Elena, Lindorff-Larsen, Kresten, Kragelund, Birthe Brandt, Nielsen, Michael Lund, Kriegenburg, F. & Hartmann-Petersen, Rasmus, 2015, In : The Journal of Biological Chemistry. 290, 34, p. 21141-21153 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. ATP Enhances Neuronal Differentiation of PC12 Cells by Activating PKC alpha Interactions with Cytoskeletal Proteins

    Marin-Vicente, C., Guerrero-Valero, M., Nielsen, Michael Lund, Savitski, M. M., Gomez-Fernandez, J. C., Zubarev, R. A. & Corbalan-Garcia, S., 2011, In : Journal of Proteome Research. 10, 2, p. 529-540 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Advances in characterizing ubiquitylation sites by mass spectrometry

    Sylvestersen, K. B., Young, C. & Nielsen, Michael Lund, 5 Jan 2013, In : Current Opinion in Chemical Biology. 17, 1, p. 49-58 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Advantages of external accumulation for electron capture dissociation in Fourier transform mass spectrometry

    Haselmann, K. F., Budnik, B. A., Olsen, Jesper Velgaard, Nielsen, Michael Lund, Reis, C. A., Clausen, H., Johnsen, A. H. & Zubarev, R. A., 2001, In : Analytical Chemistry. 73, 13, p. 2998-3005 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    An Optimized Shotgun Strategy for the Rapid Generation of Comprehensive Human Proteomes

    Bekker-Jensen, D. B., Kelstrup, C. D., Batth, Tanveer Singh, Buch-Larsen, Sara Charlotte, Haldrup, C., Bramsen, J. B., Sørensen, K. D., Høyer, S., Ørntoft, T. F., Andersen, C. L., Nielsen, Michael Lund & Olsen, Jesper Velgaard, 2017, In : Cell Systems. 4, 6, p. 587-599, e1-e4 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    An advanced strategy for comprehensive profiling of ADP-ribosylation sites using mass spectrometry-based proteomics

    Hendriks, Ivo Alexander, Buch-Larsen, Sara Charlotte & Nielsen, Michael Lund, 2019, In : Molecular and Cellular Proteomics. 18, 5, p. 1010-1026

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Analysis of in vivo histone methylation kinetics by Heavy Methyl SILAC

    Bonaldi, T., Vitale, E., Nielsen, Michael Lund, Cox, J. & Mann, M., 2009, In : Amino Acids. 37, p. 66 1 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Analytical Utility of Small Neutral Losses from Reduced Species in Electron Capture Dissociation Studied Using SwedECD Database

    Falth, M., Savitski, M. M., Nielsen, Michael Lund, Kjeldsen, F., Andren, P. E. & Zubarev, R. A., 2008, In : Analytical Chemistry. 80, 21, p. 8089-8094 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Analytical utility of mass spectral binning in proteomic experiments by SPectral Immonium Ion Detection (SPIID)

    Kelstrup, C. D., Freese, C., Heck, A. J. R., Olsen, Jesper Velgaard & Nielsen, Michael Lund, 3 Jun 2014, In : Molecular & Cellular Proteomics. 13, 8, p. 1914-1924 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Arginine Methylation by PRMT2 Controls the Functions of the Actin Nucleator Cobl

    Hou, W., Nemitz, S., Schopper, S., Nielsen, Michael Lund, Kessels, M. M. & Qualmann, B., 2018, In : Developmental Cell. 45, 2, p. 262-275.E8

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Backbone carbonyl group basicities are related to gas-phase fragmentation of peptides and protein folding

    Savitski, M. M., Kjeldsen, F., Nielsen, Michael Lund, Garbuzynskiy, S. O., Galzitskaya, O. V., Surin, A. K. & Zubarev, R. A., 2007, In : Angewandte Chemie International Edition. 46, 9, p. 1481-1484 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Biotin starvation causes mitochondrial protein hyperacetylation and partial rescue by the SIRT3-like deacetylase Hst4p

    Madsen, C. T., Sylvestersen, K. B., Young, C., Buch-Larsen, Sara Charlotte, Poulsen, J. W., Andersen, M. A., Palmqvist, E. A., Hey-Mogensen, M., Jensen, P. B., Treebak, Jonas Thue, Lisby, Michael & Nielsen, Michael Lund, 2015, In : Nature Communications. 6, 12 p., 7726.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Bub1 positions Mad1 close to KNL1 MELT repeats to promote checkpoint signalling

    Zhang, G., Kruse, Thomas, López-Méndez, B., Sylvestersen, K. B., Garvanska, Dimitriya Hristoforova, Schopper, S., Nielsen, Michael Lund & Nilsson, Jakob, 12 Jun 2017, In : Nature Communications. 8, 12 p., 15822.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    CDK-mediated activation of the SCF(FBXO) (28) ubiquitin ligase promotes MYC-driven transcription and tumourigenesis and predicts poor survival in breast cancer

    Cepeda, D., Ng, H., Sharifi, H. R., Mahmoudi, S., Cerrato, V. S., Fredlund, E., Magnusson, K., Nilsson, H., Malyukova, A., Rantala, J., Klevebring, D., Viñals, F., Bhaskaran, N., Zakaria, S. M., Rahmanto, A. S., Grotegut, S., Nielsen, Michael Lund, Szigyarto, C. A., Sun, D., Lerner, M., Navani, S., Widschwendter, M., Uhlén, M., Jirström, K., Pontén, F., Wohlschlegel, J., Grandér, D., Spruck, C., Larsson, L. & Sangfelt, O., 3 Jul 2013, In : E M B O Molecular Medicine (Online). 5, 7, p. 1067-1086 20 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Can relative cleavage frequencies in peptides provide additional sequence information?

    Budnik, B. A., Nielsen, Michael Lund, Olsen, Jesper Velgaard, Haselmann, K. F., Horth, P., Haehnel, W. & Zubarev, R. A., 2002, In : International Journal of Mass Spectrometry. 219, 1, p. 283-294 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Citrullination modulates oligodendrocyte differentiation

    Falcao, A., Meijer, M., Rinwa, P., Cummings, T., Varas, M., Liang, J., Casaccia, P., Christophorou, M., Nielsen, Michael Lund, Ernfors, P. & Castelo-Branco, G., 2017, In : Glia. 65, S1, p. E389 1 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  20. Published

    Citrullination of HP1γ chromodomain affects association with chromatin

    Wiese, M., Bannister, A. J., Basu, S., Boucher, W., Wohlfahrt, K., Christophorou, M. A., Nielsen, Michael Lund, Klenerman, D., Laue, E. D. & Kouzarides, T., 2019, In : Epigenetics & Chromatin. 12, 17 p., 21.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Citrullination regulates pluripotency and histone H1 binding to chromatin

    Christophorou, M. A., Castelo-Branco, G., Halley-Stott, R. P., Oliveira, C. S., Loos, R., Radzisheuskaya, A., Mowen, K. A., Bertone, P., Silva, J. C. R., Zernicka-Goetz, M., Nielsen, Michael Lund, Gurdon, J. B. & Kouzarides, T., 6 Mar 2014, In : Nature. 507, p. 104-108

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Comparison of electron capture dissociation and collisionally activated dissociation of polycations of peptide nucleic acids

    Olsen, Jesper Velgaard, Haselmann, K. F., Nielsen, Michael Lund, Budnik, B. A., Nielsen, P. E. & Zubarev, R. A., 2001, In : Rapid Communications in Mass Spectrometry. 15, 12, p. 969-74 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Complementary sequence preferences of electron-capture dissociation and vibrational excitation in fragmentation of polypeptide polycations

    Savitski, M. M., Kjeldsen, F., Nielsen, Michael Lund & Zubarev, R. A., 2006, In : Angewandte Chemie International Edition. 45, 32, p. 5301-5303 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Comprehensive mass-spectrometry-based proteome quantification of haploid versus diploid yeast

    de Godoy, L. M. F., Olsen, J. V., Cox, J., Nielsen, Michael Lund, Hubner, N. C., Fröhlich, F., Walther, T. C. & Mann, M., 2008, In : Nature. 455, 7217, p. 1251-4 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Comprehensive profiling of proteome changes upon sequential deletion of deubiquitylating enzymes

    Poulsen, J. W., Madsen, C. T., Young, C., Kelstrup, C. D., Grell, H. C., Henriksen, P., Jensen, Lars Juhl & Nielsen, Michael Lund, 2012, In : Journal of Proteomics. 75, 13, p. 3886-97 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. De novo peptide sequencing and identification with precision mass spectrometry

    Frank, A. M., Savitski, M. M., Nielsen, Michael Lund, Zubarev, R. A. & Pevzner, P. A., 2007, In : Journal of Proteome Research. 6, 1, p. 114-123 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Direct neuronal glucose uptake Heralds activity-dependent increases in cerebral metabolism

    Lundgaard, I., Li, B., Xie, L., Kang, H., Sanggaard, S., Haswell, J. D. R., Sun, W., Goldman, S., Blekot, S., Nielsen, Michael Lund, Takano, T., Deane, R. & Nedergaard, Maiken, 2015, In : Nature Communications. 6, 12 p., 6807.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Effectiveness of a coordinated and tailored return-to-work intervention for sickness absence beneficiaries with mental health problems

    Martin, M., Nielsen, Michael Lund, Madsen, I., Petersen, S., Lange, Theis & Rugulies, R., 2013, In : Journal of Occupational Rehabilitation. 23, 4, p. 621-30 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Electronic excitation gives informative fragmentation of polypeptide cations and anions

    Haselmann, K. F., Budnik, B. A., Kjeldsen, F., Nielsen, Michael Lund, Olsen, Jesper Velgaard & Zubarev, R. A., 2002, In : European Journal of Mass Spectrometry. 8, 2, p. 117-121 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Electrospray ionization tandem mass spectrometry sequencing of novel skin peptides from Ranid frogs containing disulfide bridges

    Samgina, T., Arternenko, K., Gorshkov, V., Lebedev, A., Nielsen, Michael Lund, Savitski, M. & Zubarev, R., 2007, In : European Journal of Mass Spectrometry. 13, 2, p. 155-163 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Experiences and perspectives of MALDI MS and MS/MS in proteomic research

    Rappsilber, J., Moniatte, M., Nielsen, Michael Lund, Podtelejnikov, A. V. & Mann, M., 2003, In : International Journal of Mass Spectrometry. 226, 1, p. 223-237 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Extent of modifications in human proteome samples and their effect on dynamic range of analysis in shotgun proteomics

    Nielsen, Michael Lund, Savitski, M. M. & Zubarev, R. A., 2006, In : Molecular and Cellular Proteomics. 5, 12, p. 2384-2391 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification

    Tessarz, P., Santos-Rosa, H., Robson, S. C., Sylvestersen, K. B., Nelson, C. J., Nielsen, Michael Lund & Kouzarides, T., 23 Jan 2014, In : Nature. 505, p. 564-568

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Hydrogen rearrangement to and from radical z fragments in electron capture dissociation of peptides

    Savitski, M. M., Kjeldsen, F., Nielsen, Michael Lund & Zubarev, R. A., 2007, In : Journal of The American Society for Mass Spectrometry. 18, 1, p. 113-120 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. HysTag--a novel proteomic quantification tool applied to differential display analysis of membrane proteins from distinct areas of mouse brain

    Olsen, Jesper Velgaard, Andersen, J. R., Nielsen, P. A., Nielsen, Michael Lund, Figeys, D., Mann, Matthias & Wisniewski, J. R., Jan 2004, In : Molecular and Cellular Proteomics. 3, 1, p. 82-92 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Identification of dominant signaling pathways from proteomics expression data

    Zubarev, R. A., Nielsen, Michael Lund, Fung, E. M., Savitski, M. M., Kel-Margoulis, O., Wingender, E. & Kel, A., 2008, In : Journal of Proteomics. 71, 1, p. 89-96 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Immunoaffinity enrichments followed by mass spectrometric detection for studying global protein tyrosine phosphorylation

    Lind, S. B., Molin, M., Savitski, M. M., Emilsson, L., Astrom, J., Hedberg, L., Adams, C., Nielsen, Michael Lund, Engstrom, A., Elfineh, L., Andersson, E., Zubarev, R. A. & Pettersson, U., 2008, In : Journal of Proteome Research. 7, 7, p. 2897-2910 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Improved Reversed Phase Chromatography of Hydrophilic Peptides from Spatial and Temporal Changes in Column Temperature

    Young, C., Podtelejnikov, A. V. & Nielsen, Michael Lund, 2 Jun 2017, In : Journal of Proteome Research. 16, 6, p. 2307-2317 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Improving protein identification using complementary fragmentation techniques in Fourier transform mass spectrometry

    Nielsen, Michael Lund, Savitski, M. M. & Zubarev, R. A., 2005, In : Molecular and Cellular Proteomics. 4, 6, p. 835-845 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Integrative Characterization of the R6/2 Mouse Model of Huntington's Disease Reveals Dysfunctional Astrocyte Metabolism

    Skotte, Niels Henning, Andersen, Jens Velde, Santos, A., Aldana Garcia, Blanca Irene, Willert, C. W., Nørremølle, Anne, Waagepetersen, Helle S. & Nielsen, Michael Lund, 2018, In : Cell Reports. 23, 7, p. 2211-2224 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells

    Samudyata, Amaral, P. P., Engström, P. G., Robson, S. C., Nielsen, Michael Lund, Kouzarides, T. & Castelo-Branco, G., 2019, In : Experimental Cell Research. 381, 1, p. 129-138 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Intramolecular hydrogen atom transfer in hydrogen-deficient polypeptide radical cations

    Nielsen, Michael Lund, Budnik, B. A., Haselmann, K. F., Olsen, Jesper Velgaard & Zubarev, R. A., 2000, In : Chemical Physics Letters. 330, 5-6, p. 558-562 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Iodoacetamide-induced artifact mimics ubiquitination in mass spectrometry

    Nielsen, Michael Lund, Vermeulen, M., Bonaldi, T., Cox, J., Moroder, L. & Mann, M., 2008, In : Nature Methods. 5, 6, p. 459-460 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Jmjd6 Catalyses Lysyl-Hydroxylation of U2AF65, a Protein Associated with RNA Splicing

    Webby, C. J., Wolf, A., Gromak, N., Dreger, M., Kramer, H., Kessler, B., Nielsen, Michael Lund, Schmitz, C., Butler, D. S., Yates, J. R., Delahunty, C. M., Hahn, P., Lengeling, A., Mann, M., Proudfoot, N. J., Schofield, C. J. & Boettger, A., 2009, In : Science. 325, 5936, p. 90-93 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Large-Scale Identification of the Arginine Methylome by Mass Spectrometry

    Sylvestersen, K. B. & Nielsen, Michael Lund, 2 Nov 2015, Current Protocols in Protein Science. Vol. 82. 17 p. (Current Protocols in Protein Science).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  46. Liquid chromatography at critical conditions: Comprehensive approach to sequence-dependent retention time prediction

    Gorshkov, A. V., Tarasova, I. A., Evreinov, V. V., Savitski, M. M., Nielsen, Michael Lund, Zubarev, R. A. & Gorshkov, M. V., 2006, In : Analytical Chemistry. 78, 22, p. 7770-7777 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)

    Altmeyer, M., Neelsen, K. J., Teloni, F., Pozdnyakova, I., Pellegrino, S., Grøfte, M., Rask, M. D., Streicher, W., Jungmichel, S., Nielsen, Michael Lund & Lukas, Jiri, 19 Aug 2015, In : Nature Communications. 6, p. 1-12 8088.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Lysine acetylation targets protein complexes and co-regulates major cellular functions

    Choudhary, Chuna Ram, Kumar, C., Gnad, F., Nielsen, Michael Lund, Rehman, M., Walther, T. C., Olsen, Jesper Velgaard & Mann, Matthias, 2009, In : Science. 325, 5942, p. 834-40 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level

    Danielsen, J. M. R., Sylvestersen, K. B., Bekker-Jensen, Simon Holst, Szklarczyk, D., Poulsen, J. W., Horn, H., Jensen, Lars Juhl, Mailand, Niels & Nielsen, Michael Lund, 1 Mar 2011, In : Molecular and Cellular Proteomics. 10, 3, p. M110.003590

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. ModifiComb, a new proteomic tool for mapping substoichiometric post-translational modifications, finding novel types of modifications, and fingerprinting complex protein mixtures

    Savitski, M. M., Nielsen, Michael Lund & Zubarev, R. A., 2006, In : Molecular and Cellular Proteomics. 5, 5, p. 935-948 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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