Michael Lund Nielsen

Michael Lund Nielsen

Professor


  1. Published

    Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)

    Altmeyer, M., Neelsen, K. J., Teloni, F., Pozdnyakova, I., Pellegrino, S., Grøfte, M., Rask, M. D., Streicher, W., Jungmichel, S., Nielsen, Michael Lund & Lukas, Jiri, 19 Aug 2015, In: Nature Communications. 6, p. 1-12 8088.

    Research output: Contribution to journalJournal articlepeer-review

  2. Published

    Characterizing ADP-Ribosylation Sites Using Af1521 Enrichment Coupled to ETD-Based Mass Spectrometry

    Anagho, Holda Awah, Elsborg, Jonas Damgaard, Hendriks, Ivo Alexander, Buch-Larsen, Sara Charlotte & Nielsen, Michael Lund, 2023, Poly(ADP-Ribose) Polymerase: Methods and Protocols. Tulin, A. V. (ed.). Humana Press, p. 251-270 (Methods in Molecular Biology, Vol. 2609).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  3. Published

    Protein Interaction Screening for the Ankyrin Repeats and Suppressor of Cytokine Signaling (SOCS) Box (ASB) Family Identify Asb11 as a Novel Endoplasmic Reticulum Resident Ubiquitin Ligase

    Andresen, C. A., Smedegaard, S., Sylvestersen, K. B., Svensson, C., Iglesias Gato, Diego, Cazzamali, G., Nielsen, T. K., Nielsen, Michael Lund & Flores Morales, A., 24 Jan 2014, In: The Journal of Biological Chemistry. 289, 4, p. 2043-2054 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  4. Published

    An Optimized Shotgun Strategy for the Rapid Generation of Comprehensive Human Proteomes

    Bekker-Jensen, D. B., Kelstrup, C. D., Batth, Tanveer Singh, Buch-Larsen, Sara Charlotte, Haldrup, C., Bramsen, J. B., Sørensen, K. D., Høyer, S., Ørntoft, T. F., Andersen, C. L., Nielsen, Michael Lund & Olsen, Jesper Velgaard, 2017, In: Cell Systems. 4, 6, p. 587-599, e1-e4 18 p.

    Research output: Contribution to journalJournal articlepeer-review

  5. Published

    RNA-DNA sequence differences spell genetic code ambiguities

    Bentin, Thomas & Nielsen, Michael Lund, 2013, In: Artificial DNA. 2, 3, p. 69-70 2 p.

    Research output: Contribution to journalJournal articlepeer-review

  6. Analysis of in vivo histone methylation kinetics by Heavy Methyl SILAC

    Bonaldi, T., Vitale, E., Nielsen, Michael Lund, Cox, J. & Mann, M., 2009, In: Amino Acids. 37, p. 66 1 p.

    Research output: Contribution to journalJournal articlepeer-review

  7. Published

    SUMOylation promotes protective responses to DNA-protein crosslinks

    Borgermann, N., Ackermann, Leena, Schwertman, P., Hendriks, Ivo Alexander, Thijssen, K., Liu, Julio, Lans, H., Nielsen, Michael Lund & Mailand, Niels, 2019, In: E M B O Journal. 38, 17 p., e101496.

    Research output: Contribution to journalJournal articlepeer-review

  8. Published

    Mapping Physiological ADP-Ribosylation Using Activated Ion Electron Transfer Dissociation

    Buch-Larsen, Sara Charlotte, Hendriks, Ivo Alexander, Lodge, J. M., Rykaer, M., Furtwängler, Benjamin, Shishkova, E., Westphall, M. S., Coon, J. J. & Nielsen, Michael Lund, 2020, In: Cell Reports. 32, 12, 17 p., 108176.

    Research output: Contribution to journalJournal articlepeer-review

  9. Published

    Temporal and site-specific adp-ribosylation dynamics upon different genotoxic stresses

    Buch-Larsen, Sara Charlotte, Stripp, Alexandra, Hendriks, Ivo Alexander & Nielsen, Michael Lund, 2021, In: Cells. 10, 11, 16 p., 2927.

    Research output: Contribution to journalJournal articlepeer-review

  10. Can relative cleavage frequencies in peptides provide additional sequence information?

    Budnik, B. A., Nielsen, Michael Lund, Olsen, Jesper Velgaard, Haselmann, K. F., Horth, P., Haehnel, W. & Zubarev, R. A., 2002, In: International Journal of Mass Spectrometry. 219, 1, p. 283-294 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  11. Published

    DAXX adds a de novo H3.3K9me3 deposition pathway to the histone chaperone network

    Carraro, Massimo, Hendriks, Ivo Alexander, Hammond, Colin, Solis-Mezarino, V., Völker-Albert, M., Elsborg, Jonas Damgaard, Weisser, Melanie, Spanos, C., Montoya, Guillermo, Rappsilber, J., Imhof, A., Nielsen, Michael Lund & Groth, Anja, 2023, In: Molecular Cell. 83, 7, p. 1075-1092.e9 28 p.

    Research output: Contribution to journalJournal articlepeer-review

  12. Published

    CDK-mediated activation of the SCF(FBXO) (28) ubiquitin ligase promotes MYC-driven transcription and tumourigenesis and predicts poor survival in breast cancer

    Cepeda, D., Ng, H-F., Sharifi, H. R., Mahmoudi, S., Cerrato, V. S., Fredlund, E., Magnusson, K., Nilsson, H., Malyukova, A., Rantala, J., Klevebring, D., Viñals, F., Bhaskaran, N., Zakaria, S. M., Rahmanto, A. S., Grotegut, S., Nielsen, M. L., Szigyarto, C. A-K., Sun, D., Lerner, M. & 10 others, Navani, S., Widschwendter, M., Uhlén, M., Jirström, K., Pontén, F., Wohlschlegel, J., Grandér, D., Spruck, C., Larsson, L. & Sangfelt, O., 3 Jul 2013, In: E M B O Molecular Medicine (Online). 5, 7, p. 1067-1086 20 p.

    Research output: Contribution to journalJournal articlepeer-review

  13. Published

    Lysine acetylation targets protein complexes and co-regulates major cellular functions

    Choudhary, Chunaram, Kumar, C., Gnad, F., Nielsen, Michael Lund, Rehman, M., Walther, T. C., Olsen, Jesper Velgaard & Mann, Matthias, 2009, In: Science. 325, 5942, p. 834-40 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  14. Published

    Citrullination regulates pluripotency and histone H1 binding to chromatin

    Christophorou, M. A., Castelo-Branco, G., Halley-Stott, R. P., Oliveira, C. S., Loos, R., Radzisheuskaya, A., Mowen, K. A., Bertone, P., Silva, J. C. R., Zernicka-Goetz, M., Nielsen, Michael Lund, Gurdon, J. B. & Kouzarides, T., 6 Mar 2014, In: Nature. 507, p. 104-108

    Research output: Contribution to journalJournal articlepeer-review

  15. Published
  16. Published

    Transient suppression of SUMOylation in embryonic stem cells generates embryo-like structures

    Cossec, J. C., Traboulsi, T., Sart, S., Loe-Mie, Y., Guthmann, M., Hendriks, Ivo Alexander, Theurillat, I., Nielsen, Michael Lund, Torres-Padilla, M. E., Baroud, C. N. & Dejean, A., 2023, In: Cell Reports. 42, 4, 27 p., 112380.

    Research output: Contribution to journalJournal articlepeer-review

  17. Published

    Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level

    Danielsen, J. M. R., Sylvestersen, K. B., Bekker-Jensen, Simon Holst, Szklarczyk, D., Poulsen, J. W., Horn, H., Jensen, Lars Juhl, Mailand, Niels & Nielsen, Michael Lund, 1 Mar 2011, In: Molecular and Cellular Proteomics. 10, 3, p. M110.003590

    Research output: Contribution to journalJournal articlepeer-review

  18. Published

    Citrullination modulates oligodendrocyte differentiation

    Falcao, A., Meijer, M., Rinwa, P., Cummings, T., Varas, M., Liang, J., Casaccia, P., Christophorou, M., Nielsen, Michael Lund, Ernfors, P. & Castelo-Branco, G., 2017, In: Glia. 65, S1, p. E389 1 p.

    Research output: Contribution to journalConference abstract in journalpeer-review

  19. Published

    PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination

    Falcão, A. M., Meijer, M., Scaglione, A., Rinwa, P., Agirre, E., Liang, J., Buch-Larsen, Sara Charlotte, Heskol, A., Frawley, R., Klingener, M., Varas-Godoy, M., Raposo, A. A. S. F., Ernfors, P., Castro, D. S., Nielsen, Michael Lund, Casaccia, P. & Castelo-Branco, G., 2019, In: Cell Reports. 27, 4, p. 1090-1102.e10

    Research output: Contribution to journalJournal articlepeer-review

  20. Analytical Utility of Small Neutral Losses from Reduced Species in Electron Capture Dissociation Studied Using SwedECD Database

    Falth, M., Savitski, M. M., Nielsen, Michael Lund, Kjeldsen, F., Andren, P. E. & Zubarev, R. A., 2008, In: Analytical Chemistry. 80, 21, p. 8089-8094 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  21. SwedCAD, a database of annotated high-mass accuracy MS/MS spectra of tryptic peptides

    Falth, M., Savitski, M. M., Nielsen, Michael Lund, Kjeldsen, F., Andren, P. E. & Zubarev, R. A., 2007, In: Journal of Proteome Research. 6, 10, p. 4063-4067 5 p.

    Research output: Contribution to journalJournal articlepeer-review

  22. Published

    Serine ADP-ribosylation in Drosophila provides insights into the evolution of reversible ADP-ribosylation signalling

    Fontana, P., Buch-Larsen, Sara Charlotte, Suyari, O., Smith, R., Suskiewicz, M. J., Schützenhofer, K., Ariza, A., Rack, J. G. M., Nielsen, Michael Lund & Ahel, I., 2023, In: Nature Communications. 14, 1, 3200.

    Research output: Contribution to journalJournal articlepeer-review

  23. De novo peptide sequencing and identification with precision mass spectrometry

    Frank, A. M., Savitski, M. M., Nielsen, Michael Lund, Zubarev, R. A. & Pevzner, P. A., 2007, In: Journal of Proteome Research. 6, 1, p. 114-123 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  24. Published

    Pdx1 is post-translationally modified in vivo and serine 61 is the principal site of phosphorylation

    Frogne, T., Sylvestersen, K. B., Kubicek, S., Nielsen, Michael Lund & Hecksher-Sørensen, J., 2012, In: P L o S One. 7, 4, p. e35233

    Research output: Contribution to journalJournal articlepeer-review

  25. Published

    The ubiquitin ligase RFWD3 is required for translesion DNA synthesis

    Gallina, I., Hendriks, Ivo Alexander, Hoffmann, Saskia, Larsen, N. B., Johansen, Joachim, S.Colding-Christensen, Camilla, Schubert, Lisa, Sellés Baiget, Selene, Fábián, Z., Kühbacher, U., Gao, A. O., Räschle, M., Rasmussen, Simon, Nielsen, Michael Lund, Mailand, Niels & Duxin, Julien, 2021, In: Molecular Cell. 81, 3, p. 442-458.e9 27 p.

    Research output: Contribution to journalJournal articlepeer-review

  26. Liquid chromatography at critical conditions: Comprehensive approach to sequence-dependent retention time prediction

    Gorshkov, A. V., Tarasova, I. A., Evreinov, V. V., Savitski, M. M., Nielsen, Michael Lund, Zubarev, R. A. & Gorshkov, M. V., 2006, In: Analytical Chemistry. 78, 22, p. 7770-7777 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  27. Published

    Multisite SUMOylation restrains DNA polymerase η interactions with DNA damage sites

    Guerillon, Claire Aline, Smedegaard, S., Hendriks, Ivo Alexander, Nielsen, Michael Lund & Mailand, Niels, 2020, In: Journal of Biological Chemistry. 295, p. 8350-8362

    Research output: Contribution to journalJournal articlepeer-review

  28. Published

    DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network

    Hammond, Colin, Bao, H., Hendriks, Ivo Alexander, Carraro, Massimo, García-Nieto, A., Liu, Y., Reveron-Gomez, Nazaret, Spanos, C., Chen, L., Rappsilber, J., Nielsen, Michael Lund, Patel, D. J., Huang, H. & Groth, Anja, 2021, In: Molecular Cell. 81, 12, p. 2533-2548

    Research output: Contribution to journalJournal articlepeer-review

  29. Advantages of external accumulation for electron capture dissociation in Fourier transform mass spectrometry

    Haselmann, K. F., Budnik, B. A., Olsen, Jesper Velgaard, Nielsen, Michael Lund, Reis, C. A., Clausen, H., Johnsen, A. H. & Zubarev, R. A., 2001, In: Analytical Chemistry. 73, 13, p. 2998-3005 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  30. Electronic excitation gives informative fragmentation of polypeptide cations and anions

    Haselmann, K. F., Budnik, B. A., Kjeldsen, F., Nielsen, Michael Lund, Olsen, Jesper Velgaard & Zubarev, R. A., 2002, In: European Journal of Mass Spectrometry. 8, 2, p. 117-121 5 p.

    Research output: Contribution to journalJournal articlepeer-review

  31. Published

    Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation

    Hendriks, Ivo Alexander, Lyon, D., Young, C., Jensen, Lars Juhl, Vertegaal, A. C. O. & Nielsen, Michael Lund, Mar 2017, In: Nature Structural and Molecular Biology. 24, 3, p. 325-336 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  32. Published

    MaxQuant. Live Enables Enhanced Selectivity and Identification of Peptides Modified by Endogenous SUMO and Ubiquitin

    Hendriks, Ivo Alexander, Akimov, V., Blagoev, B. & Nielsen, Michael Lund, 2021, In: Journal of Proteome Research. 20, 4, p. 2042-2055 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  33. Published

    An advanced strategy for comprehensive profiling of ADP-ribosylation sites using mass spectrometry-based proteomics

    Hendriks, Ivo Alexander, Buch-Larsen, Sara Charlotte & Nielsen, Michael Lund, 2019, In: Molecular and Cellular Proteomics. 18, 5, p. 1010-1026

    Research output: Contribution to journalJournal articlepeer-review

  34. Published

    Site-specific characterization of endogenous SUMOylation across species and organs

    Hendriks, Ivo Alexander, Lyon, D., Su, D., Skotte, Niels Henning, Daniel, J. A., Jensen, Lars Juhl & Nielsen, Michael Lund, 2018, In: Nature Communications. 9, p. 1-17 2456.

    Research output: Contribution to journalJournal articlepeer-review

  35. Published

    The regulatory landscape of the human HPF1-and ARH3-dependent ADP-ribosylome

    Hendriks, Ivo Alexander, Buch-Larsen, Sara Charlotte, Prokhorova, E., Elsborg, Jonas Damgaard, Stripp, Alexandra, Zhu, K., Ahel, D., Lukas, Claudia, Ahel, I. & Nielsen, Michael Lund, 2021, In: Nature Communications. 12, 1, 16 p., 5893.

    Research output: Contribution to journalJournal articlepeer-review

  36. Published

    The SUMO–NIP45 pathway processes toxic DNA catenanes to prevent mitotic failure

    Hertz, Emil Peter Thrane, Alonso de Vega, Ignacio, Kruse, Thomas, Wang, Y., Hendriks, Ivo Alexander, Bizard, A. H., Eugui-Anta, A., Hay, R. T., Nielsen, Michael Lund, Nilsson, Jakob, Hickson, Ian David & Mailand, Niels, 2023, In: Nature Structural and Molecular Biology. 30, p. 1303-1313

    Research output: Contribution to journalJournal articlepeer-review

  37. Published

    Arginine Methylation by PRMT2 Controls the Functions of the Actin Nucleator Cobl

    Hou, W., Nemitz, S., Schopper, S., Nielsen, Michael Lund, Kessels, M. M. & Qualmann, B., 2018, In: Developmental Cell. 45, 2, p. 262-275.E8

    Research output: Contribution to journalJournal articlepeer-review

  38. Published

    Proteome-wide Identification of Poly(ADP-Ribosyl)ation Targets in Different Genotoxic Stress Responses

    Jungmichel, S., Rosenthal, F., Altmeyer, M., Lukas, Jiri, Hottiger, M. O. & Nielsen, Michael Lund, 24 Oct 2013, In: Molecular Cell. 52, 2, p. 272-285 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  39. Published

    Specificity and commonality of the phosphoinositide-binding proteome analyzed by quantitative mass spectrometry

    Jungmichel, S., Sylvestersen, K. B., Choudhary, Chunaram, Nguyen, S., Mann, Matthias & Nielsen, Michael Lund, 13 Feb 2014, In: Cell Reports. 6, 3, p. 578-91 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  40. Published

    The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator.

    Jungmichel, S., Clapperton, J. A., Janette, L., Hari, F. J., Spycher, C., Pavic, L., Li, J., Haire, L. F., Bonalli, M., Larsen, D. H., Lukas, C., Lukas, J., MacMillan, D., Nielsen, Michael Lund, Stucki, M. & Smerdon, S. J., 10 Jan 2012, In: Nucleic Acids Research. 40, 9, p. 4913-4928 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  41. Published

    Tousled-like kinases phosphorylate Asf1 to promote histone supply during DNA replication

    Kamalyukova, I. M., Young, C., Strømme, C. B., Ménard, Patrice, Jasencakova, Zuzana, Mejlvang, J., Ask, K., Ploug, Michael, Nielsen, Michael Lund, Jensen, O. N. & Groth, Anja, 2014, In: Nature Communications. 5, p. 3394

    Research output: Contribution to journalJournal articlepeer-review

  42. Published

    Analytical utility of mass spectral binning in proteomic experiments by SPectral Immonium Ion Detection (SPIID)

    Kelstrup, C. D., Freese, C., Heck, A. J. R., Olsen, Jesper Velgaard & Nielsen, Michael Lund, 3 Jun 2014, In: Molecular & Cellular Proteomics. 13, 8, p. 1914-1924 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  43. Published

    Optimized Fast and Sensitive Acquisition Methods for Shotgun Proteomics on a Quadrupole Orbitrap Mass Spectrometer

    Kelstrup, C. D., Young, C., Lavallee, R., Nielsen, Michael Lund & Olsen, Jesper Velgaard, 2012, In: Journal of Proteome Research. p. 3487-3497 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  44. On studying protein phosphorylation patterns using bottom-up LC-MS/MS: the case of human alpha-casein

    Kjeldsen, F., Savitski, M. M., Nielsen, Michael Lund, Shi, L. & Zubarev, R. A., 2007, In: Analyst. 132, 8, p. 768-776 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  45. PhosTShunter: A fast and reliable tool to detect phosphorylated peptides in liquid chromatography Fourier transform tandem mass spectrometry data sets

    Kocher, T., Savitski, M. M., Nielsen, Michael Lund & Zubarev, R. A., 2006, In: Journal of Proteome Research. 5, 3, p. 659-668 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  46. Published

    The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage

    Larsen, D. H., Hari, F., Clapperton, J. A., Gwerder, M., Gutsche, K., Altmeyer, M., Jungmichel, S., Toledo Lazaro, L. I., Fink, D., Rask, M., Grøfte, M., Lukas, Claudia, Nielsen, Michael Lund, Smerdon, S. J., Lukas, Jiri & Stucki, M., Aug 2014, In: Nature Cell Biology. 16, 8, p. 792-803 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  47. Published

    Proteome-wide analysis of arginine monomethylation reveals widespread occurrence in human cells

    Buch-Larsen, Sara Charlotte, Sylvestersen, K. B., Mund, Andreas, Lyon, D., Mullari, M., Madsen, M. V., Daniel, J. A., Jensen, Lars Juhl & Nielsen, Michael Lund, 30 Aug 2016, In: Science Signaling. 9, 443, 14 p., rs9.

    Research output: Contribution to journalJournal articlepeer-review

  48. Published

    Proteome-Wide Identification of In Vivo ADP-Ribose Acceptor Sites by Liquid Chromatography-Tandem Mass Spectrometry

    Buch-Larsen, Sara Charlotte, Leutert, M., Bilan, V., Martello, R., Jungmichel, S., Young, C., Hottiger, M. O. & Nielsen, Michael Lund, 2017, Poly(ADP-Ribose) Polymerase. Tulin, A. V. (ed.). Humana Press, Vol. 1608. p. 149-162 14 p. (Methods in molecular biology (Clifton, N.J.)).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  49. Published
  50. Published

    Novel serological neo-epitope markers of extracellular matrix proteins for the detection of portal hypertension

    Leeming, D. J., Karsdal, M. A., Byrjalsen, I., Bendtsen, Flemming, Trebicka, J., Nielsen, Michael Lund, Christiansen, C., Møller, Søren & Krag, A., 2013, In: Alimentary Pharmacology and Therapeutics. 38, 9, p. 1086-1096 11 p.

    Research output: Contribution to journalJournal articlepeer-review

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