Ubiquitylation at Stressed Replication Forks: Mechanisms and Functions

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Accurate duplication of chromosomal DNA is vital for faithful transmission of the genome during cell division. However, DNA replication integrity is frequently challenged by genotoxic insults that compromise the progression and stability of replication forks, posing a threat to genome stability. It is becoming clear that the organization of the replisome displays remarkable flexibility in responding to and overcoming a wide spectrum of fork-stalling insults, and that these transactions are dynamically orchestrated and regulated by protein post-translational modifications (PTMs) including ubiquitylation. In this review, we highlight and discuss important recent advances on how ubiquitin-mediated signaling at the replication fork plays a crucial multifaceted role in regulating replisome composition and remodeling its configuration upon replication stress, thereby ensuring high-fidelity duplication of the genome.

Original languageEnglish
JournalTrends in Cell Biology
Issue number7
Pages (from-to)584-597
Publication statusPublished - 2021

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Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.

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