In Silico Systems Pharmacology to Assess Drug's Therapeutic and Toxic Effects

Research output: Contribution to journalJournal articlepeer-review

Standard

In Silico Systems Pharmacology to Assess Drug's Therapeutic and Toxic Effects. / Orozco, Alejandro Aguayo; Audouze, Karine; Brunak, Soren; Taboureau, Olivier.

In: Current Pharmaceutical Design, Vol. 22, No. 46, 2016, p. 6895-6902.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Orozco, AA, Audouze, K, Brunak, S & Taboureau, O 2016, 'In Silico Systems Pharmacology to Assess Drug's Therapeutic and Toxic Effects', Current Pharmaceutical Design, vol. 22, no. 46, pp. 6895-6902. https://doi.org/10.2174/1381612822666160907093215

APA

Orozco, A. A., Audouze, K., Brunak, S., & Taboureau, O. (2016). In Silico Systems Pharmacology to Assess Drug's Therapeutic and Toxic Effects. Current Pharmaceutical Design, 22(46), 6895-6902. https://doi.org/10.2174/1381612822666160907093215

Vancouver

Orozco AA, Audouze K, Brunak S, Taboureau O. In Silico Systems Pharmacology to Assess Drug's Therapeutic and Toxic Effects. Current Pharmaceutical Design. 2016;22(46):6895-6902. https://doi.org/10.2174/1381612822666160907093215

Author

Orozco, Alejandro Aguayo ; Audouze, Karine ; Brunak, Soren ; Taboureau, Olivier. / In Silico Systems Pharmacology to Assess Drug's Therapeutic and Toxic Effects. In: Current Pharmaceutical Design. 2016 ; Vol. 22, No. 46. pp. 6895-6902.

Bibtex

@article{f073708544da4faca3ccc740bc4610b0,
title = "In Silico Systems Pharmacology to Assess Drug's Therapeutic and Toxic Effects",
abstract = "For many years, the {"}one target, one drug{"} paradigm has been the driving force behind developments in pharmaceutical research. With the recent advances in molecular biology and genomics technologies, the focus is shifting toward {"}drug-holistic{"} systems based approaches (i.e. systems pharmacology). The integration of large and diverse amount of data from chemistry and biology coupled with the development and the application of network-based approaches to cope with these data is the next paradigm of drug discovery. Systems pharmacology offers a novel way of approaching drug discovery by developing models that consider the global physiological environment of protein targets and their modification by drugs. Studying drug action across multiple scales of complexity from molecular and cellular to tissue and organism levels may help identify new druggable disease genes and to design new drugs with a better efficacy and clinical safety.",
keywords = "Journal Article",
author = "Orozco, {Alejandro Aguayo} and Karine Audouze and Soren Brunak and Olivier Taboureau",
note = "Copyright{\textcopyright} Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.",
year = "2016",
doi = "10.2174/1381612822666160907093215",
language = "English",
volume = "22",
pages = "6895--6902",
journal = "Current Pharmaceutical Design",
issn = "1381-6128",
publisher = "Bentham Science Publishers",
number = "46",

}

RIS

TY - JOUR

T1 - In Silico Systems Pharmacology to Assess Drug's Therapeutic and Toxic Effects

AU - Orozco, Alejandro Aguayo

AU - Audouze, Karine

AU - Brunak, Soren

AU - Taboureau, Olivier

N1 - Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

PY - 2016

Y1 - 2016

N2 - For many years, the "one target, one drug" paradigm has been the driving force behind developments in pharmaceutical research. With the recent advances in molecular biology and genomics technologies, the focus is shifting toward "drug-holistic" systems based approaches (i.e. systems pharmacology). The integration of large and diverse amount of data from chemistry and biology coupled with the development and the application of network-based approaches to cope with these data is the next paradigm of drug discovery. Systems pharmacology offers a novel way of approaching drug discovery by developing models that consider the global physiological environment of protein targets and their modification by drugs. Studying drug action across multiple scales of complexity from molecular and cellular to tissue and organism levels may help identify new druggable disease genes and to design new drugs with a better efficacy and clinical safety.

AB - For many years, the "one target, one drug" paradigm has been the driving force behind developments in pharmaceutical research. With the recent advances in molecular biology and genomics technologies, the focus is shifting toward "drug-holistic" systems based approaches (i.e. systems pharmacology). The integration of large and diverse amount of data from chemistry and biology coupled with the development and the application of network-based approaches to cope with these data is the next paradigm of drug discovery. Systems pharmacology offers a novel way of approaching drug discovery by developing models that consider the global physiological environment of protein targets and their modification by drugs. Studying drug action across multiple scales of complexity from molecular and cellular to tissue and organism levels may help identify new druggable disease genes and to design new drugs with a better efficacy and clinical safety.

KW - Journal Article

U2 - 10.2174/1381612822666160907093215

DO - 10.2174/1381612822666160907093215

M3 - Journal article

C2 - 27604605

VL - 22

SP - 6895

EP - 6902

JO - Current Pharmaceutical Design

JF - Current Pharmaceutical Design

SN - 1381-6128

IS - 46

ER -

ID: 177048562